Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review DOI Creative Commons

Yiting Ze,

WU Yong-yao,

Zhen Tan

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 27, 2025

Abstract Circadian rhythm is ubiquitous in nature. clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, regulate variety of physiological pathological processes, including bone cartilage metabolism. Deletion the core gene leads to alterations, while phenotypes are not consistent. Studies have shown that multiple signaling pathways involved process regulating metabolism, but exact regulatory mechanisms remain unclear. This paper reviews by which regulates bone/cartilage upstream factors control , current knockout mouse models for research. We hope provide new insights prevention treatment diseases related circadian rhythms.

Language: Английский

The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders DOI Creative Commons

Yejia Xu,

Bowen Jia,

Jing Li

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 395 - 395

Published: March 26, 2024

Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain traumatic injury, epilepsy, depression, more. The involved pathogenesis is notably intricate diverse. Ferroptosis neuroinflammation play pivotal roles elucidating the causes of cognitive impairment stemming from these diseases. Given concurrent occurrence ferroptosis due metabolic shifts such as iron ROS, well their critical central nervous disorders, investigation into co-regulatory mechanism has emerged a prominent area research. This paper delves mechanisms along with interrelationship. It specifically emphasizes core molecules within shared pathways governing neuroinflammation, including SIRT1, Nrf2, NF-κB, Cox-2, iNOS/NO·, how different immune cells structures contribute dysfunction through mechanisms. Researchers’ findings suggest that mutually promote each other may represent key factors progression disorders. A deeper comprehension common pathway between cellular holds promise for improving symptoms prognosis related

Language: Английский

Citations

18
Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease DOI Open Access
Eng H. Lo, Frank M. Faraci

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 615 - 617

Published: March 14, 2024

Language: Английский

Citations

9
Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review DOI Creative Commons

Yiting Ze,

WU Yong-yao,

Zhen Tan

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 27, 2025

Abstract Circadian rhythm is ubiquitous in nature. clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, regulate variety of physiological pathological processes, including bone cartilage metabolism. Deletion the core gene leads to alterations, while phenotypes are not consistent. Studies have shown that multiple signaling pathways involved process regulating metabolism, but exact regulatory mechanisms remain unclear. This paper reviews by which regulates bone/cartilage upstream factors control , current knockout mouse models for research. We hope provide new insights prevention treatment diseases related circadian rhythms.

Language: Английский

Citations

0