The spleen in ischaemic heart disease

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Genotype–phenotype correlations in inherited cardiomyopathies, their role in clinical decision-making, and implications in personalized cardiac medicine in multi-omics as well as disease modeling eras

Saudi Journal for Health Sciences, Journal Year: 2025, Volume and Issue: 14(1), P. 30 - 41

Published: Jan. 1, 2025

Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities the myocardium. Understanding genotype–phenotype correlations these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies predictive diagnostics. This review explores major types inherited cardiomyopathies–hypertrophic cardiomyopathy, dilated arrhythmogenic restrictive cardiomyopathy–and provides detailed insights into how different manifest as clinical features. The integration multi-omics approaches advanced disease modeling techniques has enhanced our ability to dissect correlations. also discusses implications findings including tailored strategies, diagnostics, future research directions. JOURNAL/sjfhs/04.03/01772839-202501000-00004/figure1/v/2025-04-19T121403Z/r/image-tiff

Language: Английский

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Common features between aging and cancer: a narrative review

Aging advances., Journal Year: 2024, Volume and Issue: 1(2), P. 118 - 134

Published: Dec. 1, 2024

Aging is a complex biological process characterized by gradual deterioration in physiological activities, contributing to an elevated risk of different age-associated malignancies, including cancer. The current review paper aims elucidate the association between hallmarks aging and parallel development Various cellular molecular mechanisms underlying such as senescence, genomic instability, telomere shortening play significant role accumulation genetic mutations disruption activities. It has also discussed immune system’s aging, indicating how age-linked dysfunction compromises body’s capacity recognize eradicate pre-tumorous cells, thus promoting cancer advancement. This examines affects tumor microenvironment, where age-related alterations stromal extracellular matrix factors lead conditions that promote growth proliferation. Furthermore, it discusses concept “accelerated aging” survivors, highlighting negative effects its therapy intensify process, resulting greater physical cognitive decline. explores prospect new therapies target aging-related processes ameliorate outcomes. Overall, underscores need for ongoing interdisciplinary research understand relationship cancer, ultimately aiming develop more effective prevention treatment approaches.

Language: Английский

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Review: Single Cell Advances in investigating and understanding Chronic Kidney Disease and Diabetic Kidney Disease

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

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Interface Between Cardioimmunology, Myocardial Health, and Disease: A Compendium

Circulation Research, Journal Year: 2024, Volume and Issue: 134(12), P. 1661 - 1662

Published: June 6, 2024

Language: Английский

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