Cited by Unraveling cadmium-driven liver inflammation with a focus on arachidonic acid metabolites and TLR4/ IκBα /NF-κB pathway

Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade DOI

Zhuoran Jia,

Jian‐Lin Wu, Fang Liu

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 11, 2025

The impact of a high-salt (HS) diet on metabolic disturbances in individuals with coronary heart disease remains unclear. arachidonic acid (AA) pathway is closely linked to the development cardiometabolic diseases and atherosclerotic cardiovascular diseases. Furthermore, endoplasmic reticulum stress (ERS) has emerged as major contributor AA-related inflammation ERS are hypothesized play role HS diet-induced remodeling. Rats were subjected an for 4 weeks, serum concentration AA was measured via enzyme-linked immunosorbent assay. Immunofluorescence staining vascular tension measurements conducted arteries. In addition, AA-stimulated artery smooth muscle cells (CASMCs) treated inhibitors explore underlying involved. Increased susceptibility myocardial infarction diet-fed rats accompanied by increased concentrations expression key enzyme cyclooxygenase-2 (COX-2). incubation weakened contraction denuded arteries, reduced markers, fluorescence intensity synthetic response markers Further investigation CASMCs revealed that AA-induced phenotypic transformation mediated pathway. found be stimulated following diet. triggers through COX-2 catalysis, downstream inositol requiring 1 - X-box binding protein-1 osteopontin may contribute CASMCs, resulting dysfunctional tension. This study provide potential therapeutic targets associated excessive AA-derived ERS.

Language: Английский

Citations

Integrated network pharmacology and metabolomics analysis to reveal the potential mechanism of Ershen Wan in ameliorating ulcerative colitis DOI

Mingyang Wang,

Meiyu Wan,

Meijuan Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119690 - 119690

Published: March 1, 2025

Language: Английский

Citations

Deciphering the causality of gut microbiota, circulating metabolites and heart failure: a mediation mendelian DOI

Xueqing Guan,

Chaonan Sun,

Jianyao Su

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Background Growing evidence suggesting a connection between the gut microbiome, plasma metabolites, and development of heart failure (HF). However, causality this relationship remains to be fully elucidated. Methods Utilizing summary statistics from extensive genome-wide association studies (GWAS), we investigated interplay among 1,400 metabolites failure. We conducted bidirectional Mendelian randomization (MR) analyses MR mediation analysis discern within these relationships. The inverse variance-weighted (IVW) method served as our primary analytical approach, supported by various methods sensitivity analyses. Results revealed casual relationships nine microbial groups/pathways Additionally, 15 exhibited links with HF, eight exerting protective effects. Through two-step also identified metabolite, Campesterol, mediated increasing risk microbiota HF metabolite ratio played converse role. Conclusion This investigation has provided robust supporting causal findings enhance comprehension role circulating offer significant insights for future etiological research therapeutic in

Language: Английский

Citations

Metabolomic profiles and health-promoting potential of Euchresta japonica tissues revealed by widely targeted metabolomics DOI

Liai Xu, Xi Liu, Xiaoyong Pan

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Euchresta japonica , a medicinal plant in Chinese herbal medicine, lacks comprehensive metabolite data to explain its health benefits despite long-standing use. Here, widely targeted metabolome at six different tissues of E. was investigated, identifying 2,140 metabolites, including flavonoids, phenolic acids, amino lipids, and alkaloids. Among them, 305 were annotated as key active ingredients, 364 pharmaceutical ingredients for nine human disease-resistance, with 206 co-annotated. Metabolic profiles varied significantly across tissues, medicinally metabolites highly concentrated lateral roots inflorescences, indicating great medical potential. Notably, the root, rather than main primary source root-derived bioactive metabolites. Additionally, KEGG analysis demonstrated that secondary metabolic pathways, especially “isoflavonoid biosynthesis” “flavonoid played important roles. Overall, inflorescences exhibit strongest potential disease treatment, particularly chronic multifactorial diseases. This study advances our understanding ’s chemical composition underscores valuable resource novel therapeutic applications, providing strong foundation further investigation into pharmacological properties drug development prospects.

Language: Английский

Citations

Honey-fried licorice in the treatment of arrhythmia: structure elucidation and the mechanism of antiarrhythmic activity DOI

Yushu Wang, Yuxin Li,

Wenxin Xia

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156259 - 156259

Published: Nov. 15, 2024

Language: Английский

Citations

Unraveling cadmium-driven liver inflammation with a focus on arachidonic acid metabolites and TLR4/ IκBα /NF-κB pathway DOI

Xun Gong,

Chuanzhi Guo,

Junlin Liu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117177 - 117177

Published: Oct. 16, 2024

Language: Английский

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