Clonal hematopoiesis, cardiovascular disease and cancer treatment-induced cardiotoxicity

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Clonal Hematopoiesis Increases Hypertension and Sympathetic Activity and Is Reversed by Renal Denervation

Hypertension, Journal Year: 2025, Volume and Issue: 82(3)

Published: Feb. 19, 2025

Language: Английский

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p16INK4a Deletion Alleviated Obesity‐Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

ABSTRACT Recent research has revealed a close association between obesity and various metabolic disorders, including renal diseases, but the mechanism is still unknown. This study explored role of p16INK4a in obesity‐related kidney fibrosis evaluated its potential as therapeutic target. Using wild‐type (WT) mice p16 KO mice, we fed both groups high‐fat diet (HFD) for 6 months. Our results showed that an HFD led to significant weight gain increased expression WT mouse kidneys. Notably, presented reduced fibrosis, indicated by decreased levels profibrotic proteins (α‐SMA collagen I) improved histological outcomes, glomeruli tubules. P16 also suppressed several proinflammatory biomarkers (MMP1, MMP3, IL‐1β, TNF‐α IL‐6) inhibited NLRP3 inflammasome pathway. The administration ABT263 further validated these findings decreasing inflammation HFD‐fed suggesting contributes fibrotic inflammatory processes. Metabolomic analyses knockout influenced pathways, linoleic acid pyrimidine metabolism, HFD‐induced Additionally, over‐expression was observed kidneys chronic disease patients with long‐term hyperlipidaemia. These highlight critical obesity‐induced damage suggest targeting may be promising approach treating inflammation.

Language: Английский

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Clonal Hematopoiesis of Indeterminate Potential and Incident Hypertension: Results From the Women’s Health Initiative

Hypertension, Journal Year: 2025, Volume and Issue: 82(4)

Published: March 19, 2025

Language: Английский

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Autophagy and Its Association with Macrophages in Clonal Hematopoiesis Leading to Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3252 - 3252

Published: April 1, 2025

Atherosclerosis, a chronic inflammatory disease characterized by lipid accumulation and immune cell infiltration, is linked to plaque formation cardiovascular events. While traditionally associated with metabolism endothelial dysfunction, recent research highlights the roles of autophagy clonal hematopoiesis (CH) in its pathogenesis. Autophagy, cellular process crucial for degrading damaged components, regulates macrophage homeostasis inflammation, both which are pivotal atherosclerosis. In macrophages, influences metabolism, cytokine regulation, oxidative stress, helping prevent instability. Defective exacerbates impairs cholesterol efflux, accelerates progression. Additionally, autophagic processes cells smooth muscle further contribute atherosclerotic pathology. Recent studies also emphasize interplay between CH, wherein somatic mutations genes like TET2, JAK2, DNMT3A drive expansion enhance responses plaques. These modify function, intensifying environment accelerating Chaperone-mediated (CMA), selective form autophagy, plays critical role regulating inflammation pro-inflammatory cytokines oxidized low-density lipoprotein (ox-LDL). Impaired CMA activity leads these substrates, activating NLRP3 inflammasome worsening inflammation. Preclinical suggest that pharmacologically may mitigate atherosclerosis animal models, reduced instability increases This review importance regulation focusing on formation, contributions CH. Building upon current advances, we propose hypothesis programmed death, intrinsic axis modulates fundamental functions playing complex development Understanding mechanisms offers potential therapeutic strategies targeting reduce burden disease.

Language: Английский

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Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Clonal hematopoiesis of indeterminate potential and atrial fibrillation

Heart Rhythm, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of TET2/NLRP3 inflammasome signaling pathway

Kidney International, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Salt and CHIP: Tet2 -CH Aggravates Salt-Sensitive Hypertension in Mice

Circulation Research, Journal Year: 2024, Volume and Issue: 135(9), P. 951 - 953

Published: Oct. 10, 2024

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Tet2-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental stroke

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 17, 2024

Recent work has revealed that clonal hematopoiesis (CH) is associated with a higher risk of numerous age-related diseases, including ischemic stroke, however little known about whether it influences stroke outcome independent its widespread effects on cardiovascular disease. Studies suggest leukocytes carrying CH driver mutations have an enhanced inflammatory profile, which could conceivably exacerbate brain injury after stroke.

Language: Английский

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