Targeting Deltex E3 Ubiquitin Ligase 2 Inhibits Tumor‐associated Neutrophils and Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy DOI Creative Commons
Xiaoling Wu, Jiafeng Chen, Yiran Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Abstract Several E3 ligases have been found to affect the immune microenvironment of hepatocellular carcinoma (HCC) and lead resistance immunotherapy. In this study, genes are screened based on The Cancer Genome Atlas (TCGA) dataset. Through cytometry by time flight (CyTOF), flow cytometry, further experiments, Deltex ubiquitin ligase 2 (DTX2) in HCC cells is identified promote infiltration polarization tumor‐associated neutrophils (TANs) with a protumor phenotype, thus attenuating cytotoxicity CD8+ T partially through C‐X‐C motif chemokine (CXCL2) 6 (CXCL6). Mechanistically, DTX2 can interact histone H2B its monoubiquitination at lysine120 (H2BK120ub1), thereby increasing CXCL2 CXCL6 transcription epigenetic regulation. Different tumor models vivo demonstrated that inhibitor treatment inhibited growth sensitized therapeutic effects programmed cell death protein 1 (PD‐1) antibody. summary, study identifies as potential target for

Language: Английский

Illuminating the enigmatic pathogenesis of Kawasaki disease: Unveiling novel therapeutic avenues by targeting FCGR3B-S100A12 pathway DOI Creative Commons
Meng Wu,

Wenyan Wang,

Zhicheng Yang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 987, P. 177154 - 177154

Published: Dec. 2, 2024

Kawasaki disease (KD) primarily affects the pediatric population and exhibits a notable incidence of drug resistance, resulting in coronary artery damage thrombosis. This study aimed to identify innovative therapeutic targets for KD treatment. By harnessing single-cell data derived from peripheral blood mononuclear cells, we identified differentially expressed genes. Through integration eQTL Mendelian randomization analysis, FCGR3B S100A12 were causally linked KD. The DrugBank database showed their potential as target candidates. GSEA further elucidated roles on Furthermore, have confirmed that ligand-FCGR3B complex enhances intracellular calcium concentration (Ca

Language: Английский

Citations

0
Involvement of USP7 in aggravating Kawasaki disease by promoting TGFβ2 signaling mediated endothelial-mesenchymal transition and coronary artery remodeling DOI

Guanghui Qian,

Yan Wang, Hongwei Yao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113823 - 113823

Published: Dec. 13, 2024

Language: Английский

Citations

0
Targeting Deltex E3 Ubiquitin Ligase 2 Inhibits Tumor‐associated Neutrophils and Sensitizes Hepatocellular Carcinoma Cells to Immunotherapy DOI Creative Commons
Xiaoling Wu, Jiafeng Chen, Yiran Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 29, 2024

Abstract Several E3 ligases have been found to affect the immune microenvironment of hepatocellular carcinoma (HCC) and lead resistance immunotherapy. In this study, genes are screened based on The Cancer Genome Atlas (TCGA) dataset. Through cytometry by time flight (CyTOF), flow cytometry, further experiments, Deltex ubiquitin ligase 2 (DTX2) in HCC cells is identified promote infiltration polarization tumor‐associated neutrophils (TANs) with a protumor phenotype, thus attenuating cytotoxicity CD8+ T partially through C‐X‐C motif chemokine (CXCL2) 6 (CXCL6). Mechanistically, DTX2 can interact histone H2B its monoubiquitination at lysine120 (H2BK120ub1), thereby increasing CXCL2 CXCL6 transcription epigenetic regulation. Different tumor models vivo demonstrated that inhibitor treatment inhibited growth sensitized therapeutic effects programmed cell death protein 1 (PD‐1) antibody. summary, study identifies as potential target for

Language: Английский

Citations

0