Computational Mechanics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 31, 2024
Abstract
We
derive
a
three-dimensional
hydrogel
model
as
two-phase
system
of
fibre
network
and
liquid
solvent,
where
the
nonlinear
elastic
accounts
for
strain-stiffening
properties
typically
encountered
in
biological
gels.
use
this
to
formulate
free
boundary
value
problems
layer
that
allows
swelling
or
contraction.
two-dimensional
plain-strain
plain-stress
approximations
thick
thin
layers
respectively,
are
subject
external
loads
serve
minimal
scaffolds
cell
attachment
growth.
For
collective
evolution
cells
they
mechanically
interact
with
layer,
we
couple
it
an
agent-based
also
traction
force
exerted
by
each
on
sheet
other
during
migration.
develop
numerical
algorithm
coupled
present
results
influence
strain-stiffening,
geometry,
load
solvent
in/outflux
shape
patterns.
In
particular,
discuss
alignment
chain
formation
under
varying
conditions.
iScience,
Journal Year:
2024,
Volume and Issue:
27(10), P. 110770 - 110770
Published: Aug. 23, 2024
Cardiac
patch
strategies
are
developed
as
a
promising
approach
to
regenerate
the
injured
heart
after
myocardial
infarction
(MI).
This
study
integrated
3D
bioprinting
and
cardioprotective
paracrine
signaling
fabricate
vascular
devices
containing
endothelial
cells
(ECs)
regenerative
follistatin-like
1
(FSTL1)
peptide.
Engineered
supported
culture
of
ECs
in
both
static
dynamic
culture,
forming
uniform
endothelium
on
printed
channels.
Implantation
onto
rat
model
acute
MI
resulted
significant
reduction
scar
formation,
left
ventricle
dilation,
wall
thinning,
well
enhanced
ejection
fraction.
Furthermore,
increased
vascularization
proliferation
cardiomyocytes
were
observed
hearts
treated
with
patches.
These
findings
highlight
remarkable
capacity
bioprinted
augment
endogenous
mammalian
heart,
together
exogenous
function,
serve
robust
therapeutic
device
treat
MI.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(37), P. 48880 - 48894
Published: Sept. 3, 2024
Myocardial
infarction
(MI)
is
a
serious
cardiovascular
disease
with
high
morbidity
and
mortality
rates,
posing
significant
threat
to
patient's
health
quality
of
life.
Following
MI,
the
damaged
myocardial
tissue
typically
not
fully
repaired,
leading
permanent
impairment
function.
While
traditional
treatments
can
alleviate
symptoms
reduce
pain,
their
ability
repair
heart
muscle
limited.
Functionalized
hydrogels,
broad
category
materials
diverse
functionalities,
enhance
properties
hydrogels
cater
needs
engineering,
drug
delivery,
medical
dressings,
other
applications.
Recently,
functionalized
have
emerged
as
promising
new
therapeutic
approach
for
treatment
MI.
possess
outstanding
biocompatibility,
customizable
mechanical
properties,
drug-release
capabilities.
These
enable
them
offer
scaffold
support,
release,
regeneration
promotion,
making
treating
This
paper
aims
evaluate
advancements
delivery
methods
while
also
discussing
potential
challenges
they
may
pose
future
clinical
use.
Computational Mechanics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 31, 2024
Abstract
We
derive
a
three-dimensional
hydrogel
model
as
two-phase
system
of
fibre
network
and
liquid
solvent,
where
the
nonlinear
elastic
accounts
for
strain-stiffening
properties
typically
encountered
in
biological
gels.
use
this
to
formulate
free
boundary
value
problems
layer
that
allows
swelling
or
contraction.
two-dimensional
plain-strain
plain-stress
approximations
thick
thin
layers
respectively,
are
subject
external
loads
serve
minimal
scaffolds
cell
attachment
growth.
For
collective
evolution
cells
they
mechanically
interact
with
layer,
we
couple
it
an
agent-based
also
traction
force
exerted
by
each
on
sheet
other
during
migration.
develop
numerical
algorithm
coupled
present
results
influence
strain-stiffening,
geometry,
load
solvent
in/outflux
shape
patterns.
In
particular,
discuss
alignment
chain
formation
under
varying
conditions.
