Pharmacological Research, Journal Year: 2024, Volume and Issue: 211, P. 107573 - 107573
Published: Dec. 31, 2024
Language: Английский
Circulation Research, Journal Year: 2025, Volume and Issue: 136(5), P. 524 - 550
Published: Feb. 27, 2025
Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.
Language: Английский
Citations
3
Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Language: Английский
Citations
0
Seminars in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 170, P. 103610 - 103610
Published: April 10, 2025
Language: Английский
Citations
0
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 14, 2025
Abstract Newborn mammals transiently maintain the heart regenerative capacity. β-adrenergic receptor (β-AR) is most critical in regulating cardiomyocyte behavior. However, role and mechanism of β-AR, especially subtypes regeneration remain unclear. Here, we reveal that β-AR inhibits by downregulating Yap m6A modification. The expression associated with After apical resection, (including β 1 -AR 2 -AR) regeneration. exerts a more potent inhibitory effect compared -AR. Mechanistically, both downregulate modification then YAP differentially reducing METTL14 IGF2BP1, respectively. Elevation adenoviruses encoding IGF2BP1 rescues proliferation inhibited -AR, These findings indicate inhibit m6A-dependent manner subtype-specific mechanism. results will provide new intervention strategy for
Language: Английский
Citations
0
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: April 15, 2025
Language: Английский
Citations
0
Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 94, P. 102517 - 102517
Published: April 17, 2025
Cardiomyocyte signalling pathways are central to maintaining the structural and functional integrity of heart. Dysregulation these contributes onset progression heart diseases, including failure, arrhythmias cardiomyopathies. This review focuses on very recent work dysfunctional cardiomyocyte its role in pathophysiology disease. We discuss key pathways, immune within cardiomyocytes, associated with microtubule dysfunction, Hippo-yes-associated protein adenosine monophosphate-activated kinase signalling, highlighting how aberrations their regulation lead impaired functions pinpointing potential therapeutic opportunities pathways. underscores complexity networks emphasises need for further dissecting prevent dysfunction.
Language: Английский
Citations
0
The Journal of Cardiovascular Aging, Journal Year: 2024, Volume and Issue: 4(4)
Published: Dec. 31, 2024
Acetyltransferases are enzymes that catalyze the transfer of an acetyl group to a substrate, modification referred as acetylation. Loss-of-function variants in genes encoding acetyltransferases can lead congenital disorders, often characterized by intellectual disability and heart muscle defects. Their activity is influenced dietary nutrients alter coenzyme A levels, key cofactor. Cardiovascular diseases, including ischemic, hypertensive, diabetic diseases - leading causes mortality elderly largely attributed prolonged lifespan growing prevalence metabolic syndrome. thus serve crucial link between lifestyle modifications, cardiometabolic disease, aging through both epigenomic non-epigenomic mechanisms. In this review, we discuss roles relevance acetyltransferases. While sirtuin family deacetylases has been extensively studied longevity, particularly fasting-mediated NAD+ metabolism, recent research brought attention essential health aging-related pathways, cell proliferation, DNA damage response, mitochondrial function, inflammation, senescence. We begin with overview acetyltransferases, classifying them domain structure, canonical non-canonical lysine N-terminal sialic acid O-acetyltransferases. then advances understanding acetyltransferase-related pathologies, focusing on cardiovascular disease aging, explore their potential therapeutic applications for promoting older individuals.
Language: Английский
Citations
2
Circulation, Journal Year: 2024, Volume and Issue: 151(1), P. 94 - 97
Published: Dec. 26, 2024
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2024, Volume and Issue: 211, P. 107573 - 107573
Published: Dec. 31, 2024
Language: Английский
Citations
0