Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(11), P. 3327 - 3348

Published: July 28, 2023

Language: Английский

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Atherogenic Activation of Human Vascular Smooth Muscle Cells by Monosodium Urate Crystals

Gout Urate and Crystal Deposition Disease, Journal Year: 2023, Volume and Issue: 1(3), P. 192 - 207

Published: Aug. 14, 2023

Gout is strongly associated with atherosclerosis and other cardiovascular comorbidities. Furthermore, sites of extra-articular monosodium urate (MSU) crystal deposits in gout can include heart valves atherosclerotic artery plaques, but unclear effects therein. Hence, we seminally explored cultured vascular smooth muscle cell (VSMC) responsiveness to MSU crystals. To limit confounding effects, human aortic VSMCs under serum-free conditions assess on VSMC differentiation function, differentially expressed genes (DEGs) via RNA sequencing, selected atherogenic changes cytokines the lipidome. crystals induced p38 phosphorylation, IL-6, vacuolization dysregulated autophagy. MSU-crystal-induced DEGs included decreased late-stage autophagosome maturation mediator GABARAPL1, physiologic regulators (LMOD1 SYNPO2), increased ATF4, CHOP, intrinsic apoptosis signaling pathway response ER stress, neointimal nuclear receptors (NR4A1 NR4A3). alone levels cholesterol biosynthetic intermediates 14-demethyl-lanosterol (14-DML), desmosterol, zymosterol. Adding oxidized LDL’s capacity increase intracellular 27-OH cholesterol, LDL synergistically a marked release arachidonate. In conclusion, deposited arterial media neointima have potential dysregulate proteostasis, induce further which enhanced loading IL-6 arachidonic acid (AA).

Language: Английский

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Male Hyperuricemia Is Associated with Poor Reproductive Outcomes of IVF-ET

Andrologia, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Objective . To investigate the effect of male hyperuricemia on reproductive outcome in vitro fertilization‐embryo transfer (IVF‐ET). Methods Clinical data 412 couples who underwent their first cycle IVF‐ET were analyzed. According to serum uric acid (SUA) level male, they divided into control group (SUA ≤ 416 μ mol/L) and > mol/L). The primary secondary observation indices pregnancy after quality fresh embryo IVF. Binary logistic regression was used analyze relationship between SUA related outcomes. ROC curve biochemical loss rate (BPLR) transplantation drawn. Results BPLR increased significantly than that (4.7% vs. 31.6%, P = 0.012), clinical live birth lower (61.5% 39.4%, 0.038) (56.9% 33.3%, 0.027). analysis showed positively correlated with ( B 0.010, 0.019, OR 1.010, 95% CI (1.002, 1.018)). area under receiver operating characteristic 0.784, specificity 53.7%, sensitivity 100.0%, 0.010. Moreover, total fertilization 2PN those (86.0% 81.6%, 0.001) (75.0% 69.6%, < 0.001). Conclusion Male is an independent risk factor for increasing can also reduce

Language: Английский

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Associations between carotid plaque shape, biomechanical parameters, and ischemic stroke in mild carotid stenosis with a single plaque

ULTRASONOGRAPHY, Journal Year: 2024, Volume and Issue: 43(3), P. 209 - 219

Published: April 22, 2024

Purpose: This cross-sectional cohort-comparison observational study investigated the value of high-frame-rate vector flow (V Flow) imaging for evaluating differences in carotid plaque shape and biomechanical parameters patients with mild stenosis according to a recent history ipsilateral ischemic stroke.Methods: The present included 352 from February 2023 October 2023, who were categorized as symptomatic or asymptomatic based on stroke lesions detected head computed tomography magnetic resonance imaging. A Mindray Resona R9 system was used B-mode ultrasonography V Flow upstream downstream surfaces plaques examined at bifurcation wall shear stress (WSS), oscillatory index (OSI), turbulence index, which performed peri-plaque condition. Multivariable logistic regression models determine associations between shape, parameters, stroke.Results: Symptomatic exhibited higher WSS values plaque, well OSI surface. Type Ⅲ surface significantly associated stroke. more prevalent demonstrated much both groups.Conclusion: High-frame-rate could assess forces may provide effective biomarkers early prediction stenosis.

Language: Английский

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Serum uric acid and high-sensitivity C-reactive protein levels among people living with HIV on dolutegravir and ritonavir-boosted atazanavir-based antiretroviral therapy: a comparative cross-sectional study

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 17, 2024

After the introduction of antiretroviral therapy, care given to people living with HIV has become complicated by appearance comorbidities as a result and HAART toxicities, in which cardiovascular disease got most attention. So, this study aimed assess serum uric acid high-sensitivity C-reactive protein levels among on dolutegravir (DTG) ritonavir-boosted atazanavir (ATV/r)-based therapy.

Language: Английский

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