Hypertension Research, Journal Year: 2024, Volume and Issue: 47(12), P. 3356 - 3362
Published: Aug. 16, 2024
Language: Английский
Hypertension Research, Journal Year: 2024, Volume and Issue: 47(12), P. 3356 - 3362
Published: Aug. 16, 2024
Language: Английский
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 23, 2024
Importance: Some medications have effects that depend on the time of day they are given. Current knowledge time-of-day specific in hospitalized patients with cardiovascular disease is very limited. In patients, increased medication efficiency might reduce dose (and associated side effects) and/or length Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and family quality life reducing financial costs. We studied whether night Cardiac Units receive a diuretic affects urine volume. Methods: this observational study, data were collected from 7,685 (63% male, 18 to 98 years old) admitted one hospital’s Acute units, ICUs, Surgery Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements volume, for ≥3 days between January 2016 July 2021 older than years. The interest volume normalized by most recent (not 24 h) weight body mass index (BMI), (i) hour after administration, (ii) when no diuretics administered previous 3 h. Results: identified administration 23:00–04:59 as predictor higher response. For without medication, was predicted 11:00–16:59 17:00–22:59. Other factors affected response sex, age, dose, creatinine concentration, diagnoses, hospital unit. Discussion: Time-of-day may be factor efficiency. Randomized controlled trials should conducted quantify relative effect modifiable factors, such affect short- longer-term outcomes.
Language: Английский
Citations
3Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102232 - 102232
Published: Feb. 15, 2024
Circadian rhythms are involved in the regulation of many aspects body, including cell function, physical activity and disease. disturbance often predates typical symptoms neurodegenerative diseases is not only a non-motor symptom, but also one causes their occurrence progression. Glial cells possess circadian clocks that regulate function to maintain brain development homeostasis. Emerging evidence suggests microglial clock physiological processes, such as cytokine release, phagocytosis, nutritional metabolic support, disruption microglia may affect multiple Parkinson's disease, especially neuroinflammation α-synuclein processes. Herein, we review recent advances control health discuss novel pharmacological interventions for disorders.
Language: Английский
Citations
3International Archives of Occupational and Environmental Health, Journal Year: 2024, Volume and Issue: 97(4), P. 461 - 471
Published: March 2, 2024
Language: Английский
Citations
3Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: June 27, 2024
Background The study aimed to examine the association between systemic immune-inflammation index (SII), a contemporary metric of inflammatory response, and biological aging, which are closely interconnected processes. Methods This cross-sectional utilized 10 cycles data from NHANES database spanning 1990 2018. examined relationship SII index, calculated as P * N/L, where represents preoperative peripheral platelet count, N neutrophil L lymphocyte aging. Biological aging was assessed through various methods, such phenotypic age, age acceleration (PhenoAgeAccel), (BioAgeAccel). Correlations were analyzed using weighted linear regression subgroup analysis. Results Among 7,491 participants analyzed, average 45.26 ± 0.34 years, with 52.16% being female. ages 40.06 0.36 45.89 0.32 respectively. Following adjustment for potential confounders, elevated scores linked increased Phenotypic acceleration, acceleration. Positive correlations observed health behavior factor stronger associations seen factors. In factor-specific analyses, β coefficient notably higher high BMI. robust positive both in stratified analyses consistently across all strata. Conclusion evidence indicate that may serve valuable marker assessing different facets outcomes, mortality process. Additional research is warranted comprehensively elucidate implications process its utility clinical instrument evaluating addressing age-related ailments.
Language: Английский
Citations
3Hypertension Research, Journal Year: 2024, Volume and Issue: 47(12), P. 3356 - 3362
Published: Aug. 16, 2024
Language: Английский
Citations
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