The Interplay Between Immunity, Inflammation and Endothelial Dysfunction

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1708 - 1708

Published: Feb. 17, 2025

The endothelium is pivotal in multiple physiological processes, such as maintaining vascular homeostasis, metabolism, platelet function, and oxidative stress. Emerging evidence the past decade highlighted immunomodulatory function of endothelium, serving a link between innate, adaptive immunity inflammation. This review examines regulation immune-inflammatory axis by discusses immune functions, explores pathophysiological processes leading to endothelial dysfunction various metabolic disturbances, including hyperglycemia, obesity, hypertension, dyslipidaemia. final section focuses on novel, repurposed, emerging therapeutic targets that address dysfunction.

Language: Английский

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Lymphocyte Subset Imbalance in Cardiometabolic Diseases: Are T Cells the Missing Link?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 868 - 868

Published: Jan. 21, 2025

Cardiometabolic and cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with well-established risk factors such as smoking, obesity, diabetes contributing to plaque formation chronic inflammation. However, emerging evidence suggests that immune system plays a more significant role in development progression CVD than previously thought. Specifically, finely tuned regulation lymphocyte subsets governs post-injury inflammation tissue damage resolution orchestrates functions activation endothelial cells, cardiomyocytes, fibroblasts CVD-associated lesions (e.g., atherosclerotic plaques). A deeper understanding system’s involvement will provide new insights into disease biology uncover novel therapeutic targets aimed at re-establishing homeostasis. In this review, we summarize current state knowledge on distribution CVD, including atherosclerosis, diabetes, hypertension, myocardial infarction, stroke.

Language: Английский

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Multi-Scale Multi-Cell Computational Model of Inflammation-Mediated Aortic Remodeling in Hypertension

Annals of Biomedical Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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Hypertension is associated with global and renal damage accrual in patients with systemic lupus erythematosus. Data from the Almenara Lupus Cohort

Lupus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Objectives To determine the association between occurrence of hypertension and damage accrual in patients with systemic lupus erythematosus (SLE). Materials methods From January 2012 to 2020, we evaluated 314 SLE patients, all members Almenara Lupus Cohort. We applied American College Cardiology/American Heart Association (ACC/AHA) guidelines define hypertension, Systemic International Collaborating Clinics/American Rheumatology Damage Index (SDI) organ damage, Erythematosus Disease Activity (SLEDAI-2K) assess disease activity. performed univariable multivariable analysis using generalized estimating equations, adjusting for potential confounders (demographic factors, disease-related factors treatment). Results 1695 visits were included; 93% women. Their mean duration was 6.8 years (SD: 6.4), their age at diagnosis 35.7 13.4) years. Baseline 0.8 1.2) first visit, increasing by 0.15 points subsequent follow-up visit 0.46). The prevalence these 56.4% least once during follow-up. In analysis, remained associated (IRR: 1.645, 95% CI: 1.187–2.280, p = 0.003) after confounders. analyses per domain, renal model (OR: 4.331, CI 1.547–12.126, 0.005). Conclusion Hypertension greater our patients. Thus, providers involved on care should monitor blood pressure clinic visits.

Language: Английский

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Pregnancy-Induced Hypertension and Association With Future Autoimmune Diseases

Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

OBJECTIVE: To explore the associations between hypertensive disorders of pregnancy and subsequent development autoimmune diseases. METHODS: This retrospective cohort study used TriNetX, a federated network real-world data. Using Global Collaborative Network data, we collected electronic medical records from 102 health care organizations with 131 million patient 2006 to 2020. The assessed risk diseases in women aged 16–45 years. Two cohorts were compared: pregnancy-induced hypertension cohort, which included gestational hypertension, preeclampsia, or eclampsia, normotensive cohort. Women preexisting those complications occurring before 20 weeks gestation excluded. Propensity score matching was ensure balanced cohorts. primary outcome long-term during follow-up period up 18 secondary evaluated association both patient's age severity hypertension. RESULTS: prevalence found be 13.4%. After propensity matching, among 289,564 women, demonstrated significantly higher developing follow-up. systemic lupus erythematosus notably (hazard ratio 1.87, 95% CI, 1.60–2.18), along elevated risks multiple sclerosis, Addison disease, antiphospholipid syndrome, inflammatory bowel mixed connective tissue rheumatoid arthritis. Subgroup analysis revealed that advanced maternal had similar compared younger women. In addition, these increased CONCLUSION: history face diseases, emphasizing need for ongoing monitoring preventive care.

Language: Английский

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Toll-like receptor 9 contributes to perivascular adipose tissue dysfunction in spontaneously hypertensive rats

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177524 - 177524

Published: March 1, 2025

Language: Английский

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Personalized approach to the treatment of patients with arterial hypertension: focus on imidazoline receptor agonists. Opinion on the problem

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2025, Volume and Issue: 24(2), P. 4342 - 4342

Published: March 17, 2025

Hypertension (HTN) remains one of the most pressing problems modern healthcare. Morbidity and mortality associated with HTN continue to increase, despite a wide range available antihypertensive agents regular updates related clinical guidelines. In October 2024, an annual forum was held discuss optimization approaches treatment HTN. During discussion, special attention paid personalized therapy patients, which should be based on concepts disease pathogenesis individual risk factors. addition, validity prescribing imidazoline receptor agonists, are additional that lower blood pressure, in certain situations discussed, along main five classes drugs. routine practice, it is recommended consider use centrally acting drugs, particular moxonidine, control hypertension as part combination therapy. A central sympathetic inhibition moxonidine ensures pressure has pleiotropic effects, among important increase tissue sensitivity insulin. This especially for patients obesity, metabolic syndrome, prediabetes, type 2 diabetes, various disorders (hyperglycemia, dyslipidemia, hyperuricemia) women peri- postmenopausal period.

Language: Английский

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Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 00(00)

Published: March 25, 2025

Hypertension represents a highly prevalent chronic condition and stands among the foremost contributors to premature mortality on global scale. Its etiopathogenesis is intricate multifaceted, being shaped by diverse array of elements such as age, genetic predisposition, activation neuroendocrine apparatus. Mounting evidence has shed light significant part that autoimmune responses play in hypertension ensuing damage end organs. Virtually all varieties immune cells, spanning both innate adaptive compartments, exhibit close correlation with progression hypertension. These cells infiltrate kidney vascular mesenchyme, subsequently discharging potent cytokines, reactive oxygen species, metalloproteinases. This cascade events can affect functionality local blood vessels potentially precipitate adverse structural functional alterations crucial organs like heart kidney. In recent times, management end-organ emerged pivotal scientific focus. A multitude researchers are actively engaged probing efficacious intervention regimens, which immunotherapy strategies hold considerable promise anticipation prospective avenue.

Language: Английский

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Vγ6/Vδ1+ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice

Journal of Hypertension, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Objectives: γδ T cells mediate angiotensin II (AngII)-induced hypertension and vascular injury. expressing specific T-cell receptor (TCR) variable (V) γ chains develop in several waves the thymus migrate to or diverse tissues. We hypothesized that Vγ subtypes perivascular tissue AngII hypertensive effects. Methods: C57BL/6J male mice were infused not with (490 ng/kg/min, subcutaneously) for 14 days. profiled by flow cytometry spleen, descending thoracic aorta adherent adipose (DTAo/PVAT) mesenteric vessels (MV)/PVAT. Other sets of AngII-infused injected control anti-Vγ6 Vγ4 antibodies. Blood pressure (BP) was determined telemetry, artery function remodeling pressurized myography. Results: Vγ6/Vδ1 + represented more than 50% DTAo/PVAT MV/PVAT, whereas Vγ1/2 , most abundant spleen. The frequency increased at least 1.5-fold spleen DTAo/PVAT, tended increase MV/PVAT AngII. A majority activated neutralization caused a steeper BP elevation greater endothelial dysfunction This associated three-fold – Depletion did alter detrimental Conclusion: reduce induced infusion.

Language: Английский

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Hypertension research 2024 update and perspectives: basic research

Hypertension Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Language: Английский

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