Associations between heavy metal exposure and vascular age: a large cross-sectional study

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 3, 2025

Heavy metal exposure is an emerging environmental risk factor linked to cardiovascular disease (CVD) through its effects on vascular ageing. However, the relationship between heavy and age have not been fully elucidated. This cross-sectional study analyzed data from 3,772 participants in National Health Nutrition Examination Survey (NHANES) 2005 2016. We measured urinary concentrations of nine metals assessed their associations with age, estimated pulse wave velocity (ePWV) heart (HVA). Additionally, sex-stratified analyses, Weighted Quantile Sum (WQS) regression Bayesian Kernel Machine Regression were conducted explore individual mixed exposures. Exposure such as cadmium (Cd) cesium (Cs), cobalt (Co), lead (Pb) was significantly associated increased odds ratios (OR) ranging 1.05 3.48 full adjusted models. Sex-stratified analyses indicated that including (Co) exposures had a more substantial impact males. WQS analysis consistently showed combined stronger men (OR for HVA = 3.89, 95% CI 2.91–5.28). highlights significant association age. Stratified illustrated might be susceptible multiple exposure. The findings underscore importance considering sex-specific responses interventions measures assessments managements. Further research needed validate these develop precise public health strategies targeting risks.

Language: Английский

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Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity

Current Environmental Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 18, 2025

Zinc is an essential micronutrient with a myriad of key roles in human health. This review summarizes mechanistic data supporting the protective effects zinc on metal toxicity and discusses framework for interventional clinical trial supplementation within exposed Native American community. Many metals have common underlying mechanisms that contribute to adverse health effects. Studies demonstrate multiple aspects can be attributed disruption zinc-dependent functions. Multiple lines evidence suggest may confer protection against populations mixed-metal exposures. Thinking mechanism-informed intervention study test potential benefits while maintaining culturally responsive research approach. The current knowledge diverse interactions, coupled strong context toxic exposures, supports hypothesis mitigate impact exposures chronic mixed low status.

Language: Английский

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Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 241 - 241

Published: Jan. 20, 2025

Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of factors, including climate change, air pollution, chemicals like PFAS, heavy metals, on health. Chronic exposure these pollutants contributes inflammation, oxidative stress, endothelial dysfunction, further exacerbating global burden CVDs. Specifically, carbon monoxide (CO), ozone, particulate matter (PM2.5), nitrogen dioxide (NO2), sulfur (SO2), pesticides, micro- nanoplastics been implicated in morbidity mortality through various mechanisms. PM2.5 leads inflammation metabolic disruptions. Ozone CO induce stress vascular dysfunction. NO2 cardiac remodeling acute events, metals exacerbate cellular damage. Pesticides microplastics pose emerging risks linked tissue Monitoring risk assessment play a crucial role identifying vulnerable populations assessing pollutant impacts, considering factors age, gender, socioeconomic status, lifestyle disorders. This review explores disease, discussing risk-assessment methods, intervention strategies, challenges clinicians face addressing pollutant-induced diseases. It calls for stronger regulatory policies, public health interventions, green urban planning.

Language: Английский

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Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association

Circulation, Journal Year: 2024, Volume and Issue: 149(20)

Published: April 15, 2024

Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures cardiovascular diseases. degradation is widely prevalent has a long latency period exposure outcome, potentially placing large number individuals at risk these consequences. Emerging evidence suggests that in early life may be key factors for conditions across the span. Children particularly sensitive population detrimental effects given long-term cumulative early-life on outcomes, congenital heart disease, acquired cardiac diseases, accumulation disease factors. This scientific statement highlights representative examples each subtypes their determinants, focusing specifically climate change airborne particulate matter Kawasaki blood lead levels pressure, endocrine-disrupting chemicals with cardiometabolic Because children dependent caregivers to address concerns, this need clinicians, research scientists, policymakers focus more linkages adolescents.

Language: Английский

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Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation, Journal Year: 2024, Volume and Issue: 150(10), P. 758 - 769

Published: Aug. 1, 2024

BACKGROUND: Exposure to metals has been associated with cardiovascular disease (CVD) end points and mortality, yet prospective evidence is limited beyond arsenic, cadmium, lead. In this study, we assessed the association of urinary incident CVD all-cause mortality in a racially diverse population US adults from MESA (the Multi-Ethnic Study Atherosclerosis). METHODS: We included 6599 participants (mean [SD] age, 62.1 [10.2] years; 53% female) available at baseline (2000 2001) followed through December 2019. used Cox proportional hazards models estimate adjusted hazard ratio 95% CI by levels tungsten, uranium (nonessential metals), cobalt, copper, zinc (essential metals). The joint 6 as mixture corresponding 10-year survival probability was calculated using Elastic-Net. RESULTS: During follow-up, 1162 developed CVD, 1844 died. behavioral clinical indicators, ratios (95% CI) for comparing highest lowest quartile were, respectively: 1.25 (1.03, 1.53) 1.68 (1.43, 1.96) cadmium; 1.20 (1.01, 1.42) 1.16 1.33) tungsten; 1.32 (1.08, 1.62) (1.12, 1.56) uranium; 1.24 1.48) 1.37 (1.19, 1.58) cobalt; 1.42 (1.18, 1.70) 1.50 (1.29, 1.74) copper; 1.21 1.45) 1.38 (1.20, 1.59) zinc. A positive linear dose-response identified cadmium copper both points. an interquartile range (IQR) increase these difference were 1.29 (1.11, –1.1% (–2.0, –0.05) 1.66 (1.47, 1.91) –2.0% (–2.6, –1.5) mortality. CONCLUSIONS: This epidemiological study indicates that metal are increased risk These findings can inform development novel preventive strategies improve health.

Language: Английский

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Edetate Disodium–Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes

JAMA, Journal Year: 2024, Volume and Issue: 332(10), P. 794 - 794

Published: Aug. 14, 2024

In 2013, the Trial to Assess Chelation Therapy (TACT) reported that edetate disodium (EDTA)-based chelation significantly reduced cardiovascular disease (CVD) events by 18% in 1708 patients with a prior myocardial infarction (MI).

Language: Английский

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Lead Poisoning

New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 391(17), P. 1621 - 1631

Published: Oct. 30, 2024

Chronic lead poisoning, even at low levels, is a risk factor for cardiovascular disease in adults and cognitive deficits children. The authors review the effects of chronic, low-level poisoning.

Language: Английский

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A U.S. Lead Exposure Hotspots Analysis

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

To identify U.S. lead exposure risk hotspots, we expanded upon geospatial statistical methods from a published Michigan case study. The evaluation of identified hotspots using five indices, based on housing age and sociodemographic data, showed moderate-to-substantial agreement with state-identified higher-risk locations nine public health department reports (45–78%) children's blood data Ohio (e.g., Cohen's kappa scores 0.49–0.63). Applying cluster analysis 80th–100th percentile to the number census tracts ranged ∼8% (intersection indices) ∼41% (combination indices). Analyses children <6 years old living in those revealed states Illinois, Michigan, New Jersey, York, Ohio, Pennsylvania, Massachusetts, California, Texas) counties highest potential risk. Results support use available indices as surrogates absence consistent, complete level (BLL) across United States. Ground-truthing local knowledge, additional BLL environmental is needed improve identification for interventions. While science evolves, these screening results can inform "deeper dive" analyses targeting actions.

Language: Английский

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Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2)

American Heart Journal, Journal Year: 2024, Volume and Issue: 273, P. 72 - 82

Published: April 15, 2024

Language: Английский

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Proteomics, Human Environmental Exposure, and Cardiometabolic Risk

Circulation Research, Journal Year: 2024, Volume and Issue: 135(1), P. 138 - 154

Published: April 25, 2024

BACKGROUND: The biological mechanisms linking environmental exposures with cardiovascular disease pathobiology are incompletely understood. We sought to identify circulating proteomic signatures of and examine their associations cardiometabolic respiratory in observational cohort studies. METHODS: tested the relations >6500 proteins 29 across built environment, green space, air pollution, temperature, social vulnerability indicators ≈3000 participants CARDIA study (Coronary Artery Risk Development Young Adults) 4 centers using penalized ordinary linear regression. In >3500 from FHS (Framingham Heart Study) JHS (Jackson Study), we evaluated prospective envirome mortality Cox models. RESULTS: Proteomic identified novel/established disease–relevant pathways including DNA damage, fibrosis, inflammation, mitochondrial function. were broadly related phenotypes (eg, body mass index, lipids, left ventricular mass) CARDIA, replication FHS/JHS. A signature was associated a composite disease/mortality (1428 events; FHS: hazard ratio, 1.16 [95% CI, 1.08–1.24]; P =1.77×10 −5 ; JHS: 1.25 1.14–1.38]; =6.38×10 −6 ratio expressed as per 1 SD increase signature), robust adjustment for known clinical risk factors. CONCLUSIONS: Environmental an inflammatory-metabolic proteome, which identifies individuals outcomes. Future work examining dynamic impact environment on human health is warranted.

Language: Английский

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