Structured Exercise Therapy Increases Endogenous Antioxidants to Repair Muscle Strength and Health in Porcine Ischemic Myopathy Model of Peripheral Artery Disease DOI
Carson Hoffmann,

Dennis G. Foster,

Emma Fletcher

et al.

Advances in Wound Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Objective: The mechanisms of structured exercise therapy (SET) in peripheral artery disease (PAD) are not clear. We have developed an SET module for our large animal model ischemic myopathy. hypothesized that would increase muscle strength and walking distance this model. objective was to discover the SET-dependent involved process. Approach: After induction unilateral hind limb ischemia, three animals were exposed standard environmental enrichment (sedentary or SED) four underwent thrice weekly 4 weeks postoperatively. Walking, pressure indices, testing performed weekly. Terminal samples used skeletal testing. Results: increased over time. both nonischemic limb. When comparing SED with + SET, group has improved respiration decreased oxidative stress. Markers cell death impaired functional regeneration muscles but returned toward baseline muscle. Innovation: This study uses a validated, myopathy similar seen humans PAD. effects on function, strength, health reported Conclusion: increases by increasing endogenous antioxidants mitochondrial respiration, resulting favorable despite ongoing ischemia. may assist preclinical PAD therapies designed improve health. [Figure: see text].

Language: Английский

Structured Exercise Therapy Increases Endogenous Antioxidants to Repair Muscle Strength and Health in Porcine Ischemic Myopathy Model of Peripheral Artery Disease DOI
Carson Hoffmann,

Dennis G. Foster,

Emma Fletcher

et al.

Advances in Wound Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Objective: The mechanisms of structured exercise therapy (SET) in peripheral artery disease (PAD) are not clear. We have developed an SET module for our large animal model ischemic myopathy. hypothesized that would increase muscle strength and walking distance this model. objective was to discover the SET-dependent involved process. Approach: After induction unilateral hind limb ischemia, three animals were exposed standard environmental enrichment (sedentary or SED) four underwent thrice weekly 4 weeks postoperatively. Walking, pressure indices, testing performed weekly. Terminal samples used skeletal testing. Results: increased over time. both nonischemic limb. When comparing SED with + SET, group has improved respiration decreased oxidative stress. Markers cell death impaired functional regeneration muscles but returned toward baseline muscle. Innovation: This study uses a validated, myopathy similar seen humans PAD. effects on function, strength, health reported Conclusion: increases by increasing endogenous antioxidants mitochondrial respiration, resulting favorable despite ongoing ischemia. may assist preclinical PAD therapies designed improve health. [Figure: see text].

Language: Английский

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