Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study DOI Creative Commons
Matthew S. Durstenfeld, Melissa P. Wilson, Catherine M. Jankowski

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 11, 2023

Abstract Background People with HIV (PWH) have lower exercise capacity compared to uninfected peers, which may be explained by chronotropic incompetence (CI), the inability increase heart rate during exercise. Methods The Exercise for Healthy Aging Study included adults ages 50-75 and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization or high additional weeks. We adjusted reserve (AHRR; CI <80%) on cardiopulmonary testing serostatus, change from baseline 24 using mixed effects models. Results Among 32 PWH 37 controls (median age 56, 7% female, mean BMI 28 kg/m 2 ), 28% 11% had at (p=0.067). AHRR was among (91 vs 102%; difference 11%, 95% 2.5-19.7; p=0.01). At week 12, normalized (+8%, 4-11; p<0.001) sustained (+5, 95%CI 1-9; p=0.008) no (95%CI –4 4; p=0.95; p interaction =0.004). After only 15% 10% (p=0.70). Conclusions Chronotropic contributes reduced improves training.

Language: Английский

Advances in the Management of Cardiovascular Disease in the Setting of Human Immunodeficiency Virus DOI
Matthew S. Durstenfeld, Priscilla Y. Hsue

Infectious Disease Clinics of North America, Journal Year: 2024, Volume and Issue: 38(3), P. 517 - 530

Published: June 13, 2024

Language: Английский

Citations

2
Association of chronotropic incompetence with reduced cardiorespiratory fitness in older adults with HIV DOI Open Access
Krisann K. Oursler,

Brandon C. Briggs,

Alicia Lozano

et al.

AIDS, Journal Year: 2024, Volume and Issue: 38(6), P. 825 - 833

Published: Jan. 11, 2024

Objective: Understanding the physiological drivers of reduced cardiorespiratory fitness in people with HIV (PWH) will inform strategies to optimize healthspan. Chronotropic incompetence is common heart failure and associated low yet understudied PWH. The objective was determine prevalence chronotropic its relationship fitness. Design: Participants were PWH at least 50 years age no prior history or coronary disease who enrolled a randomized exercise trial. Baseline cardiopulmonary testing (CPET) used measure as peak oxygen consumption (VO 2 peak) calculate index from rate values. defined an less than 80%. Results: 74 participants on average 61 old, 80% Black African American, 93% men. present 31.1%. VO significantly lower among compared without [mean (SD) ml/min/kg: 20.9 (5.1) vs. 25.0 (4.5), P = 0.001]. Linear regression showed that independent predictors peak, but smoking comorbidity not. correlated ( r 0.48, < 0.001). Conclusion: Among older disease, approximately one-third individuals clinically relevant impaired Investigation large cohorts which includes may contribute promote healthy aging infection offer preclinical window for intervention.

Language: Английский

Citations

2
Chronotropic incompetence in HIV infection DOI
Eoin R. Feeney, Vicente Boix, Priscilla Y. Hsue

et al.

AIDS, Journal Year: 2024, Volume and Issue: 38(6), P. 921 - 923

Published: April 4, 2024

aUCD Centre for Experimental Pathogen Host Research, University College Dublin, Ireland bHospital General Universitario Dr Balmis cInstituto de Investigación Sanitaria y Biomédica Alicante (ISABIAL), Alicante, Spain dDivision of Cardiology, California, San Francisco, CA, USA. Correspondence to Eoin R. Feeney, MB, BCh, PhD, D04 C1P1, Ireland. E-mail: [email protected] Received 31 January, 2024 Accepted 12 February,

Language: Английский

Citations

1
Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study DOI
Matthew S. Durstenfeld, Melissa P. Wilson, Catherine M. Jankowski

et al.

The Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: May 28, 2024

People with HIV (PWH) have lower exercise capacity than peers without HIV, which may be explained by chronotropic incompetence, the inability to increase heart rate during exercise.

Language: Английский

Citations

0
Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study DOI Creative Commons
Matthew S. Durstenfeld, Melissa P. Wilson, Catherine M. Jankowski

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 11, 2023

Abstract Background People with HIV (PWH) have lower exercise capacity compared to uninfected peers, which may be explained by chronotropic incompetence (CI), the inability increase heart rate during exercise. Methods The Exercise for Healthy Aging Study included adults ages 50-75 and without HIV. Participants completed 12 weeks of moderate intensity exercise, before randomization or high additional weeks. We adjusted reserve (AHRR; CI <80%) on cardiopulmonary testing serostatus, change from baseline 24 using mixed effects models. Results Among 32 PWH 37 controls (median age 56, 7% female, mean BMI 28 kg/m 2 ), 28% 11% had at (p=0.067). AHRR was among (91 vs 102%; difference 11%, 95% 2.5-19.7; p=0.01). At week 12, normalized (+8%, 4-11; p<0.001) sustained (+5, 95%CI 1-9; p=0.008) no (95%CI –4 4; p=0.95; p interaction =0.004). After only 15% 10% (p=0.70). Conclusions Chronotropic contributes reduced improves training.

Language: Английский

Citations

0