Associations between depression symptom burden and delirium risk: a prospective cohort study DOI Creative Commons

Arlen Gaba,

Peng Li, Xi Zheng

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 23, 2023

Abstract BACKGROUND AND OBJECTIVES Delirium and depression are increasingly common in aging. There is considerable clinical overlap, including shared symptoms comorbid conditions, Alzheimer’s disease (AD), functional decline, mortality. Despite this, the long-term relationship between delirium remains unclear. This study assessed associations of symptom burden its trajectory with risk a 12-year prospective older individuals during hospitalization. RESEARCH DESIGN METHODS 319,141 UK biobank participants 2006-2010 (mean 58y [range 37-74, SD=8], 54% female) reported frequency (0-3) four depressive (mood, disinterest, tenseness, or lethargy) preceding 2 weeks, aggregated into score (0-12). New-onset was obtained from hospitalization records 12y median follow-up. 40,451 age 57±8; range 40-74y) had repeat assessment on average 8y after their first. Cox proportional hazard models examined whether predicted incident RESULTS 5,753 (15 per 1000) newly developed Increased for seen mild (aggregated scores 1-2, hazards ratio, HR=1.16, [95% confidence interval 1.08–1.25], p <0.001), modest (scores 3-5, 1.30 [1.19–1.43], <0.001) severe ≥ 5, 1.38 [1.24–1.55], symptoms, versus none fully adjusted model. These findings were independent number hospitalizations consistent across settings (e.g., surgical, medical, critical care) specialty neuropsychiatric, cardiorespiratory other). Worsening (≥1 point increase), compared to no change/improved score, associated an additional 39% increased (1.39 [1.03–1.88], =0.03) baseline burden. The association strongest those over 65y at ( interaction <0.001). DISCUSSION IMPLICATIONS Depression worsening awareness subclinical may be warranted prevention.

Language: Английский

Circadian Rhythm, Microglia-Mediated Neuroinflammation, and Alzheimer’s Disease DOI
Fan Geng, Na Zhao, Qingguo Ren

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 170, P. 106044 - 106044

Published: Feb. 4, 2025

Language: Английский

Citations

3
Associations between depression symptom burden and delirium risk: a prospective cohort study DOI Creative Commons

Arlen Gaba,

Peng Li, Xi Zheng

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 23, 2023

Abstract BACKGROUND AND OBJECTIVES Delirium and depression are increasingly common in aging. There is considerable clinical overlap, including shared symptoms comorbid conditions, Alzheimer’s disease (AD), functional decline, mortality. Despite this, the long-term relationship between delirium remains unclear. This study assessed associations of symptom burden its trajectory with risk a 12-year prospective older individuals during hospitalization. RESEARCH DESIGN METHODS 319,141 UK biobank participants 2006-2010 (mean 58y [range 37-74, SD=8], 54% female) reported frequency (0-3) four depressive (mood, disinterest, tenseness, or lethargy) preceding 2 weeks, aggregated into score (0-12). New-onset was obtained from hospitalization records 12y median follow-up. 40,451 age 57±8; range 40-74y) had repeat assessment on average 8y after their first. Cox proportional hazard models examined whether predicted incident RESULTS 5,753 (15 per 1000) newly developed Increased for seen mild (aggregated scores 1-2, hazards ratio, HR=1.16, [95% confidence interval 1.08–1.25], p <0.001), modest (scores 3-5, 1.30 [1.19–1.43], <0.001) severe ≥ 5, 1.38 [1.24–1.55], symptoms, versus none fully adjusted model. These findings were independent number hospitalizations consistent across settings (e.g., surgical, medical, critical care) specialty neuropsychiatric, cardiorespiratory other). Worsening (≥1 point increase), compared to no change/improved score, associated an additional 39% increased (1.39 [1.03–1.88], =0.03) baseline burden. The association strongest those over 65y at ( interaction <0.001). DISCUSSION IMPLICATIONS Depression worsening awareness subclinical may be warranted prevention.

Language: Английский

Citations

3