Choroid plexus cysts on 7T MRI: Relationship to aging and neurodegenerative diseases DOI Creative Commons
Zhiming Zhen, Ruiting Zhang, Li Gui

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

The choroid plexus (CP) may play a crucial role in brain degeneration. We aim to assess whether CP cysts (CPCs), defined using ultra-high field magnetic resonance imaging (MRI), relate aging and neurodegeneration. used multi-sequence 7T MRI observe CPCs, characterizing their presence characteristics healthy younger controls, older controls (OCs), patients with Alzheimer's disease (AD), Parkinson's (PD), uremic encephalopathy. volume (CPV) CPC were compared across groups, associations between CPV features analyzed all subjects. AD group showed significantly higher number of CPCs other groups also had larger than OCs. size associated CPV. offers distinct advantage observing the high prevalence warrants further investigation. enables visualization fine structures plexus. Patients (AD) exhibit (CPCs) adults patient groups. serve as an auxiliary marker for AD.

Language: Английский

Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study DOI Creative Commons

Qianqian Xie,

Ziwei Chen,

Jiafeng Wang

et al.

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 3, 2025

Abstract Background The choroid plexus (ChP) plays an important role in producing cerebrospinal fluid (CSF) and physical dysfunction has been associated with alterations CSF circulation. However, no population-based studies have thus far examined the association of ChP function older people. Methods This cross-sectional study included 1217 participants (age ≥ 60 years; 57.35% women) MRI substudy Multimodal Interventions to delay Dementia disability rural China. volume was automatically segmented using three-dimensional T1-weighted sequences. Physical assessed Short Performance Battery (SPPB). Data were analyzed general linear regression mediation models. Results Controlling for demographic characteristics, cardiovascular risk factors, stroke, disproportionately enlarged subarachnoid-space hydrocephalus (DESH), total intracranial volume, per 1-ml increase β-coefficient -0.24 (95% confidence interval: -0.37 -0.11) SPPB summary score, being stronger females (-0.40; -0.60 -0.20) than males (-0.17; -0.33 -0.01) (p volume×sex interaction = 0.028). associations similar across three domains balance, chair stand, walking speed. In addition, increased ventricular white matter hyperintensity (WMH) volume. Mediation analysis suggested that lateral periventricular WMH significantly mediated proportion 54.22% 14.48%, respectively. Conclusion Larger is poorer adults, especially women. largely by volumes. Graphical

Language: Английский

Citations

0
Associations of choroid plexus volume with white matter hyperintensity volume and susceptibility and plasma amyloid markers in cerebral small vessel disease DOI Creative Commons
Pengcheng Liang, Meng Li, Yiwen Chen

et al.

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 23, 2025

Language: Английский

Citations

0
Choroid plexus cysts on 7T MRI: Relationship to aging and neurodegenerative diseases DOI Creative Commons
Zhiming Zhen, Ruiting Zhang, Li Gui

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

The choroid plexus (CP) may play a crucial role in brain degeneration. We aim to assess whether CP cysts (CPCs), defined using ultra-high field magnetic resonance imaging (MRI), relate aging and neurodegeneration. used multi-sequence 7T MRI observe CPCs, characterizing their presence characteristics healthy younger controls, older controls (OCs), patients with Alzheimer's disease (AD), Parkinson's (PD), uremic encephalopathy. volume (CPV) CPC were compared across groups, associations between CPV features analyzed all subjects. AD group showed significantly higher number of CPCs other groups also had larger than OCs. size associated CPV. offers distinct advantage observing the high prevalence warrants further investigation. enables visualization fine structures plexus. Patients (AD) exhibit (CPCs) adults patient groups. serve as an auxiliary marker for AD.

Language: Английский

Citations

0