Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys DOI Creative Commons
Yifei Wang, Lei Bi, Qing Li

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 24, 2025

The remnant cholesterol inflammatory index (RCII) is a novel metric that combines and high-sensitivity C-reactive protein, reflecting the metabolic risk. This study investigates association between RCII long-term risks of all-cause cause-specific mortality in middle-aged elderly populations US China. We analyzed data from National Health Nutrition Examination Survey (NHANES) China Retirement Longitudinal Study (CHARLS), including 7,565 12,932 participants aged 45 years older, respectively. were categorized into quartiles based on natural log-transformed (lnRCII) values. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) mediation analysis used to examine relationship lnRCII outcomes, adjusting for potential covariates. mean age was 59.90 ± 10.44 58.64 9.78 with 53.28% 52.50% female, showed higher (≥ 0.79 NHANES, ≥ -0.13 CHARLS) significantly associated increased risk (p < 0.001). Each standard deviation (SD) increase corresponded mortality, hazard ratios (HRs) 95% confidence interval (CI) 1.29 (95% CI: 1.21-1.36) NHANES 1.26 1.15-1.38) CHARLS. In also elevated cardiovascular (HR = 1.21, 1.08-1.35) cancer 1.30, 1.09-1.55). RCS indicated J-shaped both linear mortality. Mediation systolic blood pressure fasting plasma glucose partially mediated these associations. Subgroup analyses suggested stronger interaction 0.010). Elevated levels are population, By integrating factors, may serve as valuable tool stratification clinical decision-making.

Language: Английский

Changes in remnant cholesterol and the incidence of diabetes: Results from two large prospective cohort studies DOI
Yue Shao,

Zhenghao Li,

Min Sun

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

This study seeks to analyse the effect of change and accumulation residual cholesterol (RC) on risk diabetes. The analysis included 5124 participants from China Health Retirement Longitudinal Study (CHARLS) 2704 English Ageing (ELSA), all whom underwent two repeated RC measurements. Changes in were assessed through K-means clustering analysis, cumulative was determined using formula: by (RCfirst + RCsecond)/2 × (time interval between first second assessments). We employed Cox proportional hazards regression models changes development Individuals with consistently elevated levels (class 4) demonstrated a 1.98-fold increase diabetes 95% confidence (CI: 1.38-2.84) CHARLS 2.73-fold (95% CI: 1.69-4.38) ELSA study, compared those low 1). Similarly, increased 1.62 1.21-2.18) times 2.98 1.81-4.88) folds for highest relative lowest RC. Elevated remains substantial factor diabetes, irrespective LDL-C level. Long-term exposure high links an Therefore, maintaining optimal continuously monitoring them may contribute reducing incidence

Language: Английский

Citations

0
Exploration of the shared gene signatures and molecular mechanisms between cardioembolic stroke and ischemic stroke DOI Creative Commons
Xuan Wang, Xueyuan Liu

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

This study aimed to investigate the shared molecular mechanisms underlying cardioembolic stroke (CS) and ischemic (IS) using integrated bioinformatics analysis. Microarray datasets for CS (GSE58294, blood samples from controls) IS (GSE16561, controls; GSE22255, peripheral mononuclear cells matched were acquired Gene Expression Omnibus database. Differential expression analysis weighted gene co-expression network utilized identify genes between two diseases. Protein-protein interaction (PPI) topology analyses conducted core genes. Three machine learning algorithms employed detect biomarkers genes, diagnostic value of hub was evaluated by establishing a predictive nomogram. Immune infiltration single-sample set enrichment (ssGSEA), pathways analyzed with There 125 up-regulated 2 down-regulated IS, which mainly involved in immune inflammatory response-related biological functions. The Maximum Clique Centrality algorithm identified 25 PPI constructed ABCA1, CLEC4E, IRS2 as both performed well predicting onset risk IS. All three highly expressed compared their corresponding controls. These significantly correlated neutrophil autophagy activation Particularly, all associated extracellular trap formation, but only potential key therapeutic targets Autophagy may represent common linking these

Language: Английский

Citations

0
Apolipoprotein E Plasma Concentrations Are Predictive of Recurrent Strokes: Insights From the SPARCL Trial DOI Creative Commons
Kévin Chemello, Alexis F. Guédon,

Romuald Techer

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Background In the SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) trial, atorvastatin (80 mg per day) was compared with placebo patients recent stroke or transient ischemic attack and no known coronary artery disease. Given central role of apoE (apolipoprotein E) lipoprotein metabolism nervous system, we assessed contribution to subsequent cerebrovascular cardiovascular events this trial. Methods Results ApoE concentrations major isoforms (E2/E3/E4) were determined liquid‐chromatography high resolution mass‐spectrometry plasma samples collected at baseline from 4348 participants. Patients lowest quartile those highest quartiles concentrations. Multivariable‐adjusted hazard‐ratios (HR) 95% CIs calculated using Cox proportional hazards regression models. We found a significant association between low risk recurrent strokes (HR, 1.401 [95% CI, 1.154–1.701], P <0.001 1.467 1.260–1.708], <0.001) driven higher incidence attacks entire cohort as well separately each treatment arm SPARCL. contrast, did not significantly associate hemorrhagic also reduced 1.373 ([95% 1.064–1.772], =0.015) that was, however, only Conclusions Low are predictive recurring history attack. Registration URL: https://www.clinicaltrials.gov ; Identifier: NTC00147602.

Language: Английский

Citations

0
Remnant cholesterol predicts risk of recurrent thrombosis beyond LDL-cholesterol in patients with antiphospholipid syndrome DOI Creative Commons
Bin Cai,

Yangzhong Zhou,

Xinzhuang Yang

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Language: Английский

Citations

0
Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys DOI Creative Commons
Yifei Wang, Lei Bi, Qing Li

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 24, 2025

The remnant cholesterol inflammatory index (RCII) is a novel metric that combines and high-sensitivity C-reactive protein, reflecting the metabolic risk. This study investigates association between RCII long-term risks of all-cause cause-specific mortality in middle-aged elderly populations US China. We analyzed data from National Health Nutrition Examination Survey (NHANES) China Retirement Longitudinal Study (CHARLS), including 7,565 12,932 participants aged 45 years older, respectively. were categorized into quartiles based on natural log-transformed (lnRCII) values. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) mediation analysis used to examine relationship lnRCII outcomes, adjusting for potential covariates. mean age was 59.90 ± 10.44 58.64 9.78 with 53.28% 52.50% female, showed higher (≥ 0.79 NHANES, ≥ -0.13 CHARLS) significantly associated increased risk (p < 0.001). Each standard deviation (SD) increase corresponded mortality, hazard ratios (HRs) 95% confidence interval (CI) 1.29 (95% CI: 1.21-1.36) NHANES 1.26 1.15-1.38) CHARLS. In also elevated cardiovascular (HR = 1.21, 1.08-1.35) cancer 1.30, 1.09-1.55). RCS indicated J-shaped both linear mortality. Mediation systolic blood pressure fasting plasma glucose partially mediated these associations. Subgroup analyses suggested stronger interaction 0.010). Elevated levels are population, By integrating factors, may serve as valuable tool stratification clinical decision-making.

Language: Английский

Citations

0