International Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 32
Published: Dec. 10, 2024
Objective To identify the molecular targets of MSC-derived exosomes in treating cerebral ischemia and elucidate their therapeutic mechanisms.
Language: Английский
Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 378 - 378
Published: March 20, 2024
Ischemic stroke is a fatal and disabling disease worldwide imposes significant burden on society. At present, biological markers that can be conveniently measured in body fluids are lacking for the diagnosis of ischemic stroke, there no effective treatment methods to improve neurological function after stroke. Therefore, new ways diagnosing treating urgently needed. The neurovascular unit, composed neurons, astrocytes, microglia, other components, plays crucial role onset progression Extracellular vesicles nanoscale lipid bilayer secreted by various cells. key extracellular vesicles, which released cells unit serve as facilitators cellular communication, has been extensively documented recent literature. Here, we highlight unit-derived current status vesicle engineering treatment, problems encountered clinical translation therapies. derived from could provide an important contribution diagnostic therapeutic tools future, more studies this area should carried out.
Language: Английский
Citations
6
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Language: Английский
Citations
0
Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Acute brain injuries (ABI) caused by various emergencies can lead to structural and functional damage tissue. Common causes include traumatic injury, cerebral hemorrhage, ischemic stroke, heat stroke. Globally, ABI represent a significant portion of neurosurgical cases. Previous studies have emphasized the therapeutic potential stem cell-derived extracellular vesicles (EVs). Recent research indicates that EVs extracted from resident cells in central nervous system (CNS) also show following injury. Microglia, as innate immune CNS, respond changes internal environment altering their phenotype secreting impact CNS cells, including neurons, astrocytes, oligodendrocytes, endothelial neural (NSCs), microglia themselves. Notably, under different external stimuli, either promote neuronal survival, angiogenesis, myelin regeneration while reducing glial scarring inflammation, or they exert opposite effects. This review summarizes evaluates current findings on how microglia-derived influence after stimuli. It analyzes interaction mechanisms between discusses future directions clinical applications.
Language: Английский
Citations
0
Reproduction Fertility and Development, Journal Year: 2025, Volume and Issue: 37(6)
Published: March 27, 2025
Extracellular vesicles (EVs) contain various biological molecules, such as proteins, lipids, and diverse nucleic acids, which alter physiological pathological processes in recipient cells. This review focuses on the current understanding of characteristics EVs embryo development their potential therapeutic value treating reproductive disorders. play a crucial role early development, from fertilization to pre-implantation stage, gastrulation, cell differentiation, organogenesis. During period, interact with maternal tissue promote implantation receptivity. In regulate contributing formation maintenance. Abnormal bioactive molecules are closely related developmental Thus, have serve biomarkers. Moreover, can agents, delivering genetic material for targeted tissue/organs. The findings this highlight intercellular signaling during development. help advance assisted technologies therapies overcome infertility issues
Language: Английский
Citations
0
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16
Published: April 15, 2025
Quantitative electroencephalography (qEEG) has significantly advanced in the field of neuroscience as a highly sensitive tool for routine monitoring following stroke. It holds promise diagnosing post-stroke psychiatric disorders and evaluating treatment outcomes. This review systematically examined published papers thoroughly analyzed research findings on using qEEG indicators to monitor mental abnormalities patients with ischemic The covers key time periods, including early stage (within 72 h), subacute (72 h 1 month), chronic (over month) post-onset. current evidence suggests that correlation from (EEG) vary across different Power spectrum analysis is hotspot. summarizes analyzes specialized studies utilizing these stroke, identifying highlighted research.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114497 - 114497
Published: March 22, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 25, 2025
Neuropathic pain (NP) is a common symptom of many diseases and caused by direct or indirect damage to the nervous system. Tricyclic antidepressants serotonin-norepinephrine reuptake inhibitors are typical drugs used in clinical practice suppress pain. However, these have drawbacks, including short duration action, limited analgesic effect, possible dependence side effects. Therefore, developing more effective NP treatment strategies has become priority medical research attracted much attention. P2X7 receptor (P2X7R) non-selective cation channel activated adenosine triphosphate mainly expressed microglia central Microglial P2X7R plays an important role regulation, suggesting that it could be potential target for drug development. This review comprehensively objectively discussed latest progress P2X7R, its structural characteristics, functional properties, relationship with microglial activation polarization, mechanism therapeutic multiple models. study aimed provide in-depth insights into association between explore action pathological process translational application prospects antagonists treatment, providing scientific basis precise NP.
Language: Английский
Citations
0
Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00573 - e00573
Published: March 1, 2025
ApTOLL, a promising therapeutic agent, has demonstrated effectiveness in mitigating stroke-induced neurological damage clinical settings. Despite this, the detailed molecular mechanisms by which ApTOLL impacts ischemic stroke remain inadequately understood. In present study, we explored how modulates downstream microRNAs (miRNAs) to alleviate brain and cognitive dysfunction associated with stroke. We established rat model of Administration upregulated miR-335-5p suppressed IRAK1 expression brain. treatment significantly reduced infarct size, diminished neuronal apoptosis, attenuated pathological Additionally, led inhibition inflammation oxidative while enhancing autophagy. Similar effects were observed when was overexpressed or knocked down. Conversely, beneficial negated antagomir overexpression, suggesting that ApTOLL's neuroprotective are mediated miR-335-5p/IRAK1 pathway. Mechanistically, exerted its protective role promoting miR-335-5p, thereby reducing levels, leading amelioration damage. effectively mitigates modulating axis. These findings reveal novel mechanistic pathway for highlight potential as strategy
Language: Английский
Citations
0