Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Collateral blood vessels are unique, naturally occurring endogenous bypass that provide alternative pathways for oxygen delivery in obstructive arterial conditions and diseases. Surprisingly however, the capacity of collateral circulation to protection varies greatly among individuals, resulting a significant fraction having poor their tissues. We recently reviewed evidence presence naturally-occurring polymorphisms genes determine number diameter collaterals form during development (ie, genetic background), is major contributor this variation. The purpose review summarize current understanding other determinants flow, drawing on both animal human studies. These include level smooth muscle tone collaterals, hemodynamic forces, how (collaterogenesis), de novo formation additional new adulthood, loss with aging cardiovascular risk factor (rarefaction), remodeling (structural lumen enlargement). also emerging not only ischemic but may serve physiological function healthy individuals. Primary focus studies conducted brain, however relevant findings tissues reviewed, as questions future investigation.
Language: Английский