Theta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Introduction Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. This study investigated whether 5 Hz tACS could modulate neural oscillations in the prefrontal cortex and how this modulation impacts performance working memory (WM) tasks. Method In two sessions, 28 healthy participants received or sham over left dorsolateral (DLPFC) while performing tasks with high low WM loads. Resting-state EEG was recorded before after stimulations minutes. power measured at electrodes surrounding site. Results The results showed that significantly improved reaction time (RT) compared to stimulation. effect task-specific, as RT hit responses only load trials, no impact on low-load trials. Moreover, increased theta band pre-stimulation levels. Discussion These findings demonstrate applied DLPFC modulates post-stimulation sites – known after-effects. Furthermore, suggest enhances response speed by elevating task-related activity an optimal level task performance. Conclusion summary, highlight potential of technique specific oscillations, implications research therapeutic interventions.

Language: Английский

Acceptability, tolerability and safety of the BRIGhTMIND trial: Connectivity-guided intermittent theta-burst stimulation versus F3- repetitive transcranial magnetic stimulation for treatment-resistant depression

Comprehensive Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 152544 - 152544

Published: Nov. 4, 2024

The BRIGhTMIND study was a double-blind RCT comparing repetitive transcranial magnetic stimulation at standard simulation site (the "F3" location given by the International 10-20 system, F3-rTMS) versus connectivity-guided intermittent theta burst (cgiTBS) for treatment-resistant depression. This present reports acceptability, safety, and tolerability of F3-rTMS cgiTBS.

Language: Английский