Published: Jan. 1, 2023
My gratitude also goes to
Language: Английский
Evidence-based Complementary and Alternative Medicine, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 9
Published: March 26, 2021
This study aimed to investigate the therapeutic effects of candesartan combined with music therapy on diabetic retinopathy depression and assess molecular mechanisms. Associated animal model diabetes mellitus was established in rats. Pathological changes hippocampus were detected by haematoxylin eosin (H&E) staining. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) used detect retinal cell apoptosis. Angiotensin II (Ang II) peripheral blood neurotransmitters, including serotonin (5-HT), dopamine (DA), norepinephrine (NE) hippocampus, measured enzyme linked immunosorbent assay (ELISA). Fluorescence quantitative PCR western blotting expression brain-derived neurotrophic factor (BDNF) c-fos hippocampus. Our data showed that chromatin aggregation cytoplasmic vacuolation observable hippocampal cells rats group, while could reduce morphological depression. Compared control apoptosis significantly higher, contents 5-HT, DA, NE lower, Ang level BDNF decreased group. By contrast, or + ameliorated retina apoptosis, reduction increase AII, BDNF. Especially, further improved neurotransmitter release In conclusion, have an additive effect DM both visual impairment depression, which might serve a potential alternative treatment for this complex disease.
Language: Английский
Citations
10
RESEARCH RESULTS IN BIOMEDICINE, Journal Year: 2022, Volume and Issue: 8(4)
Published: Dec. 5, 2022
Мартыненко АВ, и др.Резилиенс-диета в «голубых зонах» … Martynenko AV, et al. "The blue zones" resilience-diet
Language: Английский
Citations
7
BMJ Open, Journal Year: 2024, Volume and Issue: 14(1), P. e075141 - e075141
Published: Jan. 1, 2024
Objectives The aim of this study was to evaluate the influence anxiety and depression on clinician decision-making in patients suffering from chronic eye disease ophthalmological clinical practice. Design setting This multicentre observational study, collaboration with WHO, included ophthalmologists their affected by disease. States were screened specific questionnaires, Patient Health Questionnaire-9 (PHQ-9) Generalized Anxiety Disorder-7 (GAD-7), self-administered before visit. In present analysis, we report data three major care centres Italy between 2021 2022. Primary secondary outcomes To assess self-reported changes ophthalmologists’ approach (communication style clinical-therapeutic strategies) decisions after knowing questionnaire scores (primary aim), analyse PHQ-9 GAD-7 diseases (secondary aim). Results 41 359 included. results showed critical status (PHQ-9 ≥5 ≥10) 258 patients. 74% cases, no actions taken based these scores; 26% they changed approach; 14% referred for psychological/psychiatric evaluation. Conclusions affect many conditions need be detected managed early improve patients’ well-being. Providing knowledge psychological can change management attitude towards referral a Further studies are needed expand our how raise awareness among regarding multimorbidity order achieve better outcomes.
Language: Английский
Citations
1
Journal of Comparative Physiology B, Journal Year: 2024, Volume and Issue: 194(3), P. 225 - 231
Published: June 1, 2024
Language: Английский
Citations
1
Acta Ophthalmologica, Journal Year: 2018, Volume and Issue: 97(2)
Published: Sept. 21, 2018
Abstract Purpose Recent studies highlighted that early diabetic neurodegeneration is present before microvascular changes are visible. Retinal can decrease retinal layer thickness. We aimed to determine whether decreased thickness already in the time course of disease. Methods A cross‐sectional analysis patients and healthy adults from German Diabetes Study ( GDS , ClinicalTrials.gov Identifier number: CT 01055093, https://clinicaltrials.gov/ct2/show/NCT01055093 ). Inclusion criteria were a diagnosis diabetes mellitus DM ) within last 12 months. layers nasal pericentral segment was measured by spectral domain ocular coherence tomography SD ‐ OCT For statistical proc mixed sas ‐version 9.4) used. Results One hundred seventy‐eight eyes 89 with type 1 (58 males, age 36 ± 11 years, BMI 25.5 4.2 kg/m²) 242 121 2 (84 53 10 31.9 6.3 disease duration less than year compared 76 38 controls (27 41 16 27.3 6.4 kg/m²). Analysis visual function did not reveal significant difference between controls. Conclusion In potential, does relate measureable
Language: Английский
Citations
11
European Journal of Ophthalmology, Journal Year: 2020, Volume and Issue: 32(1), P. 468 - 474
Published: Nov. 21, 2020
Diabetes mellitus (DM) patients are more likely to experience sleep disturbances than normal. Sleep may contribute the development of diabetic retinopathy (DR) by higher inflammatory markers in circulation. We investigated association between quality and DR.Institutional case control study with type 2 DM <10 years duration HbA1c ⩽8%; 70 cases DR controls without (NODR) (power 0.8). was assessed Pittsburg index (PSQI) questionnaire compared.Cronbach's alpha 0.777 high internal homogeneity. Global PSQI score (7.44 ± 3.99; 95%CI 6.88, 9.42) NODR (4.30 3.26; 3.87, 6.45) (p < 0.001). All disturbance scores were except duration. Poor (PSQI score>5) prevalent = 0.000) associated increasing severity 0.026). Normal latency recorded 78.57% 42.85% respectively Severe difficulty subjective 0.024), 0.002) daytime dysfunction 0.001) seen DR. Elevated observed 0.008). The optimal cut-off for global 5.5 (OR: 5.97; 2.86, 12.47) 25 min(OR: 4.89; 2.32, 10.26) respectively.Sleep is positively Our identifies cut off value a modifiable parameter like latency. It emphasizes need assessment risk
Language: Английский
Citations
10
Medicine, Journal Year: 2021, Volume and Issue: 100(51), P. e28386 - e28386
Published: Dec. 23, 2021
Abstract Background: Diabetic retinopathy (DR) is one of the common microvascular complications in diabetic patients, which characterized by progressive development and often leads to irreversible visual impairment. More seriously, DR patients suffer great psychological stress due impaired function reduced self-care ability such as anxiety depression, seriously affect quality life patients. In recent years, various therapies have been applied alleviate anxiety, achieved positive results. However, effectiveness safety different are unclear. This study aims assess effects psychotherapy on through a network meta-analysis. Methods: All randomized controlled trials (RCTs) with published before 30 November 30, 2021, will be searched PubMed, EMBASE, Cochrane Register Controlled Trials, Web Science, Chinese Scientific Journal Database, China National Knowledge Infrastructure Wanfang, Biomedical Literature Database. There no restrictions publication status language. Two researchers independently responsible for RCT screening, data extraction, evaluation. statistical analyses performed using Stata 14.0 R 4.1.2. Results: The results this meta-analysis submitted peer-reviewed journal publication. Conclusion: provide comprehensive reliable evidence-based references elucidating efficacy Ethics dissemination: Ethical approval was not required study. systematic review journal, presented at conferences, shared social media platforms. OSF Registration number: DOI 10.17605/OSF.IO/K8T27.
Language: Английский
Citations
5
Journal of Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 116, P. 112 - 119
Published: Sept. 7, 2023
Language: Английский
Citations
1
Eye & Contact Lens Science & Clinical Practice, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 4, 2023
Objectives: To investigate the sleep quality in patients with ocular graft-versus-host disease (oGVHD) compared without oGVHD after allogeneic hematopoietic stem cell transplantation (alloHCT) and healthy controls. Methods: This cross-sectional study analyzed 142 alloHCT including 94 48 without. Fifty controls were also enrolled. was diagnosed according to International Chronic Ocular GVHD Consensus Group (ICOGCG) criteria. Sleep assessed by Chinese version of Pittsburgh Quality Index (CPSQI). Poor defined as CPQSI score greater than 6. Results: Patients demonstrated a significantly higher those {7.0 [interquartile range (IQR) 5.0-10.0] vs. 5.5 [IQR 4.8–7.0], P =0.002}, especially subgroup (7.5 5.0–11.0] 6.0 5.0–8.0], =0.04) nearly double prevalence poor (58 [62%] 18 [37%], =0.006). strikingly correlated diagnosis (adjusted odds ratio [OR]=2.55, 95% confidence interval [CI]: 1.02–6.34, systemic immunosuppressants OR=2.61, CI: 1.32–5.71, =0.02). Among parameters, associated ICOGCG OR=1.20, 1.03–1.39, =0.02) lower tear film break-up time OR=0.85, 0.74–0.99, =0.05). Conclusions: an increased severity instability long-term survivorship.
Language: Английский
Citations
1
Ophthalmic surgery, lasers & imaging retina, Journal Year: 2021, Volume and Issue: 52(9), P. 498 - 504
Published: Sept. 1, 2021
BACKGROUND AND OBJECTIVE: To evaluate the impact of anxiety and sleep patterns on intravitreal injection pain. PATIENTS METHODS: This prospective, noninterventional study surveyed patients scheduled for by two retinal surgeons. A standard technique was used. Patients filled out pre-procedure General Anxiety Disorder-7 (GAD-7) Pittsburgh Sleep Quality Index (PSQI) questionnaires. Post-procedural pain assessed with a visual analogue scale. hours levels were correlated perceived RESULTS: total 140 met inclusion criteria. Mean ± deviation scores 4.9 5.6 GAD-7, 6.3 4.1 PSQI, 3.69 2.64 (rho = 0.25; P .003). Previous night's −0.16; .057) poor quality 0.14; .11) weakly correlated. Regression analysis revealed only significant predictor 1-point increase in predicted 0.10-point (B 0.10, .032). CONCLUSIONS: level best has implications pre-procedural screening. [ Ophthalmic Surgery Lasers Imaging Retina . 2021;52:498–504.]
Language: Английский
Citations
3