Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Oct. 30, 2024
Lacrimal gland enlargement is a common pathological change in patients with thyroid eye disease (TED). Tear fluid has emerged as new source of diagnostic biomarkers, but tear-based biomarkers for TED high efficacy are still lacking.
Language: Английский
Cureus, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 28, 2023
Nissl granules, traditionally recognized for their pivotal role in protein synthesis within neuronal cell bodies, are emerging as intriguing components with far-reaching implications the realm of regenerative therapeutics. This abstract encapsulates essence a comprehensive review, exploring nexus between axonal regeneration, and transformative applications medicine. The molecular intricacies granules form foundation this exploration, unraveling dynamic orchestrating cellular responses, particularly context regeneration. As we delve into interplay processes, review highlights diverse mechanisms through which these contribute to repair recovery. Beyond conventional association neurobiology, recent advancements underscore translational potential therapeutic agents. Insights involvement enhancing regeneration prompt reconsideration key players broader field evidence suggesting that modulating granule-related pathways holds promise augmenting tissue extending applicability beyond confines nervous system. aims serve valuable resource medical professionals, researchers, clinicians seeking comprehend multifaceted By illuminating intricate connections applications, work aspires catalyze further research innovation, ultimately contributing evolution strategies harness innate reparative capacities constituents.
Language: Английский
Citations
8
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34757 - 34771
Published: July 1, 2024
Dry eye disease (DED) is a chronic multifactorial ocular surface mainly caused by the instability of tear film, characterized series discomforts and even visual disorders. Oxidative stress has been recognized as an upstream factor in DED development. Diquafosol sodium (DQS) agonist P2Y2 receptor to restore integrity/stability film. With ability alternate between Ce3+ Ce4+, cerium oxide nanozymes could scavenge overexpressed reactive oxygen species (ROS). Hence, DQS-loaded nanozyme was designed boost synergistic treatment DED. Cerium with branched polyethylenimine-graft-poly(ethylene glycol) nucleating agent dispersant fabricated followed DQS immobilization via dynamic phenylborate ester bond, obtaining (defined Ce@PBD). Because mimic cascade processes superoxide dismutase catalase, Ce@PBD excessive accumulated ROS, showing strong antioxidant anti-inflammatory properties. Meanwhile, receptors conjunctival cells be stimulated Ce@PBD, which can relieve incompleteness The animal experiments demonstrated that significantly restored defect corneal epithelium increased number goblet cells, promotion secretion, best among commercial ophthalmic solutions.
Language: Английский
Citations
2
Anatomia Histologia Embryologia, Journal Year: 2024, Volume and Issue: 53(5)
Published: July 26, 2024
The dental pulp is a highly innervated tissue transmitting pain-related sensations in the tooth. Consequently, understanding intricacies of its innervation mechanism odontogenesis crucial for gaining insights into pain and developing pain-modulating agents. This study examined neuroregulatory molecules such as neurotrophic factors (nerve growth factor [NGF], brain-derived [BDNF], neurotrophin-4 [NTF-4], neurturin [NRTN]) neuroinhibitory (slit2, ephrin isoforms netrin-1) rat teeth with follicles. NGF, BDNF NRTN transcriptions showed time-dependent upregulation, particularly during root formation stage. In contrast, NTF-4 mRNA was expressed at cap stage, but became downregulated over time. Slit2 ephrin-B2 expression distinct stage then manner. Ephrin-A5 netrin-1 did not significantly change. Immunofluorescence analysis revealed robust both slit2 outer inner epithelia enamel organ, non-neurogenic tissue, 3rd molar germs. predominantly localized papilla cells odontoblasts These results suggest that molecules, BDNF, ephrin-B2, may be important identifying therapeutic targets modulating pain.
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Oct. 30, 2024
Lacrimal gland enlargement is a common pathological change in patients with thyroid eye disease (TED). Tear fluid has emerged as new source of diagnostic biomarkers, but tear-based biomarkers for TED high efficacy are still lacking.
Language: Английский
Citations
0