Research Progress on the Application of Neural Network Algorithms in XiaokeNeizhang DOI

健豪 孙

Hans Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 13(02), P. 20 - 26

Published: Jan. 1, 2024

Language: Английский

TAT-N24 enhances retinal ganglion cell survival by suppressing ZBP1-PANoptosome-mediated PANoptosis in an acute glaucoma mouse model DOI
Fei Li, Qiuxiang Zhang,

Yan Rong

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110244 - 110244

Published: Jan. 1, 2025

Language: Английский

Citations

0
Efficacy and safety of ultrasound combined with microbubbles for treating retinal artery occlusion in rats DOI
Fan Song,

Yonghong Tang,

Xinying Hu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113703 - 113703

Published: April 1, 2025

Language: Английский

Citations

0
Non-Apoptotic Programmed Cell Death as Targets for Diabetic Retinal Neurodegeneration DOI Creative Commons
Yingjia Lin,

Shuping Ke,

Weiqing Ye

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 837 - 837

Published: June 26, 2024

Diabetic retinopathy (DR) remains the leading cause of blindness among global working-age population. Emerging evidence underscores significance diabetic retinal neurodegeneration (DRN) as a pivotal biomarker in progression vasculopathy. Inflammation, oxidative stress, neural cell death, and reduction neurotrophic factors are key determinants pathophysiology DRN. Non-apoptotic programmed death (PCD) plays crucial role regulating stress response, inflammation, disease management. Therapeutic modalities targeting PCD have shown promising potential for mitigating In this review, we highlight recent advances identifying various types DRN, with specific emphasis on necroptosis, pyroptosis, ferroptosis, parthanatos, more recently characterized PANoptosis. addition, therapeutic agents aimed at regulation addressing DRN discussed.

Language: Английский

Citations

2
Discovery and optimization of 3‐(indolin‐5‐yloxy)pyridin‐2‐amine derivatives as potent necroptosis inhibitors DOI

Yaohan Lan,

Yinchun Ji,

Xia Peng

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(10)

Published: July 2, 2024

Necroptosis is a form of regulated necrotic cell death and has been confirmed to play pivotal roles in the pathogenesis multiple autoimmune diseases such as rheumatoid arthritis (RA) psoriasis. The development necroptosis inhibitors may offer promising therapeutic strategy for treatment these diseases. Herein, starting from in-house hit compound 1, we systematically performed structural optimization discover potent with good pharmacokinetic profiles. resulting 33 was inhibitor both human I2.1 cells (IC

Language: Английский

Citations

2
Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model DOI Creative Commons
Xing Tu,

Zixing Zou,

Jiahui Li

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Background: Retinal ganglion cell (RGC) death caused by acute ocular hypertension is an important characteristic of glaucoma. Receptor-interacting protein kinase 3 (RIPK3) that mediates necroptosis a potential therapeutic target for RGC death. However, the current understanding targeting agents and mechanisms RIPK3 in treatment glaucoma remains limited. Notably, artificial intelligence (AI) technologies have significantly advanced drug discovery. This study aimed to discover inhibitor with AI assistance. Methods: An model was used simulate pathological vivo . We employed series methods, including large language graph neural network models, identify compounds RIPK3. Subsequently, these candidates were validated using molecular simulations (molecular docking, absorption, distribution, metabolism, excretion, toxicity (ADMET) prediction, dynamics simulations) biological experiments (Western blotting fluorescence staining) vitro Results: AI-driven screening techniques greatly accelerate development. A compound called HG9-91-01, identified exerted neuroprotective effects Our research indicates all five recommended able protect morphological integrity cells when exposed hypoxia glucose deficiency, HG9-91-01 showed higher survival rate compared other candidates. Furthermore, found retinal structure reduce loss layers model. It also observed highly correlated inhibition PANoptosis (apoptosis, pyroptosis, necroptosis). Finally, we can regulate key proteins related PANoptosis, indicating this exerts retina inhibiting expression apoptosis, necroptosis. Conclusion: AI‐enabled discovery revealed could serve as

Language: Английский

Citations

1
Oxidative stress mediates retinal damage after corneal alkali burn through the activation of the cGAS/STING pathway DOI Creative Commons

Keli Mao,

Yanqiao Huang,

Zheng Liu

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110228 - 110228

Published: Dec. 1, 2024

Language: Английский

Citations

1
Research Progress on the Application of Neural Network Algorithms in XiaokeNeizhang DOI

健豪 孙

Hans Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 13(02), P. 20 - 26

Published: Jan. 1, 2024

Language: Английский

Citations

0