Temporal bright light at low frequency retards lens-induced myopia in guinea pigs DOI Creative Commons
Baodi Deng, Wentao Li,

Ziping Chen

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e16425 - e16425

Published: Nov. 14, 2023

Purpose Bright light conditions are supposed to curb eye growth in animals with experimental myopia. Here we investigated the effects of temporal bright at very low frequencies exposures on lens-induced myopia (LIM) progression. Methods Myopia was induced by application −6.00 D lenses over right guinea pigs. They were randomly divided into four groups based exposure different lighting conditions: constant illumination (CLI; 300 lux), high (CHI; 8,000 frequency (vLFL; 300/8,000 lux, 10 min/c), and (LFL; 20 s/c). Refraction ocular dimensions measured per week. Changes refractions analyzed paired t-tests, differences among one-way ANOVA. Results Significant myopic shifts refractive error lens-treated eyes compared contralateral all after 3 weeks (all P < 0.05). Both CHI LFL exhibited a significantly less shift LIM than CLI vLFL ( However, only showed overall axial elongation (both The decrease both correlated 0.001), except group = 0.231). condition slacked lens thickening eyes. Conclusions Temporal (0.05 Hz) appears effectively inhibit Further research is needed determine safety potential mechanism

Language: Английский

Association between serum 25-hydroxyvitamin D level and myopia in children and adolescents: a cross-sectional study DOI Open Access
Tao Qing,

Yujie Chang,

Andrew S. Day

et al.

Translational Pediatrics, Journal Year: 2024, Volume and Issue: 13(2), P. 310 - 317

Published: Feb. 1, 2024

Prior reports have indicated an inconsistent relationship between vitamin D levels and myopia in children adolescents with limited sample size. This study was undertaken to further clarify this a repeated cross-section study.

Language: Английский

Citations

6
Association between vitamin D deficiency and myopia severity among school-aged children in Indonesia DOI
Aryani Atiyatul Amra,

Delfi Delfi,

Funda Sarı

et al.

British Journal of Visual Impairment, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

The majority of myopia cases worldwide occur in developing countries. In Indonesia, the prevalence refractive disorders among school-aged children (5–19 years) is estimated to be around ±10% 66 million children. Vitamin D plays a significant role maintaining flexibility ciliary ring eye, which essential for proper lens stretching during growth. This helps prevent and delay onset myopia. Deficiency vitamin may lead changes calcium levels intracellularly, potentially disrupting contraction relaxation muscle, result development study was an analytic observational with cross-sectional approach. sample this consisted students from Darul Ihsan Islamic Boarding School, selected using consecutive sampling method. Visual acuity assessed by utilizing Snellen chart, D3 were evaluated enzyme-linked immunosorbent assay (ELISA) test. included female participants (26 subjects, 52%), median age 13 years. Most had mild (29 58%), followed moderate (15 30%) severe (6 12%). mean level subjects 40.32 ± 20.99 nmol/L. highlighted differences between each degree at School. findings conclude that lower are risk factor

Language: Английский

Citations

0
Visual environmental risk factors in outdoor activities and near work and potential mechanisms DOI
Dan‐Lin Li, Carla Lança, Seang‐Mei Saw

et al.

Ophthalmic and Physiological Optics, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Purpose Myopia is highly prevalent among children and adolescents results from abnormal refractive development. Less outdoor time as well more near work have been recognised major risk factors for myopia. This study analysed the environmental related to myopia, such activities work, reviewed potential mechanisms of myopia Methods A systematic search was conducted across PubMed, Web Science, Cochrane Library Ovid databases within last two decades up November 2024. review followed recommendations PRISMA Statement only full‐text articles in English were included. Results Summarising findings 13 articles, included lighting features low illumination monochromatic light aspects visual scene, example, presence spatial frequencies hyperopic defocus. These particular stimuli may contribute onset progression increase retinal disorders by reducing choroidal blood flow, leading scleral hypoxia remodelling. When analysing factors, it challenging isolate individual contributions work. Furthermore, previous studies used different definitions exposures. Conclusions Future research needs quantitative, objective standardised measures improve comparability consistency between studies. In addition, should focus on ethnic populations gene–environment studies, so determine influence

Language: Английский

Citations

0
Insights into Myopia from Mouse Models DOI

Reece Mazade,

Teele Palumaa, Machelle T. Pardue

et al.

Annual Review of Vision Science, Journal Year: 2024, Volume and Issue: 10(1), P. 213 - 238

Published: April 18, 2024

Animal models are critical for understanding the initiation and progression of myopia, a refractive condition that causes blurred distance vision. The prevalence myopia is rapidly increasing worldwide, increases risk developing potentially blinding diseases. Current pharmacological, optical, environmental interventions attenuate in children, but it still unclear how this occurs or these can be improved to increase their protective effects. To optimize interventions, directed mechanistic studies needed. mouse model well-suited because its well-characterized visual system genetic experimental tools available, which combined with pharmacological manipulations powerful investigations causation. This review describes aspects support use as presents genetic, significantly contribute our mechanisms underlie myopigenesis.

Language: Английский

Citations

2
Effect of exogenous calcitriol on myopia development and axial length in guinea pigs with form deprivation myopia DOI Creative Commons
Rong‐Bin Liang, Wen‐Qing Shi, Tao Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 18, 2024

Abstract The annual increase in myopia prevalence poses a significant economic and health challenge. Our study investigated the effect of calcitriol role by inducing condition guinea pigs through form deprivation for four weeks. Untargeted metabolomics methods were used to analyze differences metabolites vitreous body, expression vitamin D receptor (VDR) retina was detected. Following deprivation, received intraperitoneal injections at different concentrations. We assessed progression using diopter measurements biometric analysis after Results indicated that led pronounced shift towards myopia, characterized reduced choroidal scleral thickness, disorganized collagen fibers, decreased fiber diameter. Notably, reduction diminished levels blood, VDR protein retinal tissues observed myopic pigs. Calcitriol administration effectively slowed progression, preserved prevented findings highlight decrease expressions demonstrate exogenous supplementation can halt development, enhancing thickness

Language: Английский

Citations

2
Exploration of the pathophysiology of high myopia via proteomic profiling of human corneal stromal lenticules DOI Creative Commons

Yanze Yu,

Zhe Zhang, Fei Xia

et al.

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 238, P. 109726 - 109726

Published: Nov. 17, 2023

This study aimed to investigate the underlying pathophysiology of high myopia by analyzing proteome human corneal stromal lenticule samples obtained through small incision extraction (SMILE). A total thirty-two patients who underwent SMILE were included in study. Label-free quantitative proteomic analysis was performed on samples, equally representing (n = 10) and low groups. The identified profiled proteomes analyzed using silico tools explore biological characteristics differentially expressed proteins (DEPs). Additionally, LASSO regression random forest model employed identify key associated with myopia. DEPs found be closely linked immune activation, extracellular matrix, cell adhesion-related pathways according gene ontology analysis. Specifically, decreased expression COL1A1 increased CDH11 pathogenesis validated western blotting 6) real time polymerase chain reaction 6). Overall, this provides evidence that may contribute based comparative profiling lenticules SMILE.

Language: Английский

Citations

5
The Role of Vitamin D3 in Ocular Diseases DOI Open Access
Małgorzata Mrugacz,

Kamila Pieńczykowska,

Anna Bryl

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1878 - 1878

Published: June 14, 2024

Vitamin D3 plays a vital role in numerous physiological processes within the human body, including having positive effect on eye health. It is renowned for its immunomodulatory, anti-inflammatory, antioxidant, and angiogenic properties. Its deficiency evolving into significant global challenge. In order to explain connection between vitamin various ocular diseases, 84 relevant studies, mainly from PubMed database, published English 1999 2024 were analyzed. Ocular tissues can activate regulate D levels, which emphasizes significance of this nutrient maintaining homeostasis. While there suggestive evidence probable association health, more robust research needed establish causation inform clinical guidelines.

Language: Английский

Citations

1
Temporal bright light at low frequency retards lens-induced myopia in guinea pigs DOI Creative Commons
Baodi Deng, Wentao Li,

Ziping Chen

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e16425 - e16425

Published: Nov. 14, 2023

Purpose Bright light conditions are supposed to curb eye growth in animals with experimental myopia. Here we investigated the effects of temporal bright at very low frequencies exposures on lens-induced myopia (LIM) progression. Methods Myopia was induced by application −6.00 D lenses over right guinea pigs. They were randomly divided into four groups based exposure different lighting conditions: constant illumination (CLI; 300 lux), high (CHI; 8,000 frequency (vLFL; 300/8,000 lux, 10 min/c), and (LFL; 20 s/c). Refraction ocular dimensions measured per week. Changes refractions analyzed paired t-tests, differences among one-way ANOVA. Results Significant myopic shifts refractive error lens-treated eyes compared contralateral all after 3 weeks (all P < 0.05). Both CHI LFL exhibited a significantly less shift LIM than CLI vLFL ( However, only showed overall axial elongation (both The decrease both correlated 0.001), except group = 0.231). condition slacked lens thickening eyes. Conclusions Temporal (0.05 Hz) appears effectively inhibit Further research is needed determine safety potential mechanism

Language: Английский

Citations

0