Choroidal thickness under pilocarpine versus cyclopentolate

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

Language: Английский

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Age and Gender-Related Changes in Choroidal Thickness: Insights from Deep Learning Analysis of Swept-Source OCT Images

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104511 - 104511

Published: Feb. 1, 2025

The choroid is a vital vascular layer of the eye, essential for maintaining ocular health. Understanding its structural variations, particularly choroidal thickness (CT), crucial early detection diseases, such as age-related macular degeneration (AMD), high myopia (HM), and diabetes mellitus (DM). Recent advancements in deep learning have significantly improved segmentation measurement layers. This study aims to investigate age- gender-related changes CT components through analysis swept-source optical coherence tomography (SS-OCT) images. A total 262 participants (136 females 126 males) were recruited from Peking University International Hospital. Exclusion criteria included pathologies systemic conditions. SS-OCT was utilized CT, Sattler layer-choriocapillaris complex (SLCCT), Haller (HLT) measurements. auto-measurement method, based on algorithms, ensured accuracy. Ethics approval informed consent obtained all participants. Significant thinning SLCCT observed after age 60, with HLT declining 30. Females exhibited marked between ages 40 50, while males began show at 60. research highlights thickness, particular emphasis gender differences. findings suggest that experience earlier thinning, potentially attributable hormonal changes. Additionally, validates efficiency algorithms measuring thereby enhancing reliability clinical practice.

Language: Английский

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Cone Mosaic in Eyes with Varied Axial Length Using Adaptive Optics Scanning Laser Ophthalmoscopy

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104517 - 104517

Published: Feb. 1, 2025

Abnormalities in cone photoreceptor topography are closely associated with the development of various ocular diseases, including axial myopia. Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) enables high-resolution, single-cell imaging living human retina. This study aimed to investigate potential relationship between and myopia using a commercial AOSLO system. A total 74 participants (148 eyes; 30 men, 40.5%) mean age 31.8 ± 10.4 years were included. Cone mosaics imaged at 3° 5° eccentricities fovea centralis. The relationships parameters (linear density, spacing, dispersion, regularity) length analyzed. Linear density significantly decreased increasing both (all P < 0.001). spacing increased greater reduced density. After adjusting for length, was only linear dispersion longer lower remained inferior (β = -0.43, 0.014) (β=-0.4, P=0.003). regularity higher certain (nasal: β=0.34, P<0.001; temporal: β=0.25, P=0.006; inferior: β 0.2, 0.04) temporal eccentricity -0.57, uniformity distribution disrupted as result reduction Additionally, diminished myopia, potentially due direct effects elongation or reductions eccentricity.

Language: Английский

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Comprehensive Visualization of Choroidal Alterations in Thyroid Eye Disease With Ultra-Widefield OCT Angiography

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(2), P. 25 - 25

Published: Feb. 10, 2025

To evaluate choroidal and optic disc alterations in eyes with thyroid eye disease (TED) compared healthy by using TowardPi widefield optical coherence tomography angiography (OCTA). This was a retrospective cross-sectional cohort study. A total of 112 participants (60 TED patients 52 controls) underwent OCTA, which provided detailed demographic clinical data. Three-dimensional data, including thickness, vascular metrics, measurements, were obtained from the built-in software. The study included 24 dysthyroid neuropathy (DON), active non-DON TED, 71 inactive 104 eyes. Choroidal thickness significantly decreased region during DON phase (148.71 ± 78.98 µm) to normal (182.35 51.98 (191.34 58.86 (P = 0.030). In DON, stromal volume reduced (34,183.81 10,649.01 × 106 µm3) (46,339.53 16,711.99 0.002), whereas index increased (42.67% 3.41%) (38.53% 6.35%) 0.002). Optic area (1.99 1.24 mm2) (1.39 0.38 < 0.001), along retinal nerve fiber layer blood-flow density (45.09% 3.07%,) (47.84% 1.41%) 0.001). highlights critical role pathophysiology underscore utility OCTA identifying these changes, particularly DON-risk patients.

Language: Английский

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Spatial heterogeneity of corneal biomechanical properties in myopia at nanoscale: A preliminary study

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110277 - 110277

Published: Feb. 1, 2025

Language: Английский

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