Corrected Axial Length and Choroidal Thickness: A Correlation Analysis for Scientific Purposes

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 15 - 15

Published: Jan. 2, 2025

Purpose: Choroidal thickness (ChT) is an important measurement for evaluating eye and systemic disorders, but it influenced by numerous elements, especially axial length (AL). It known that the presence of a linear relationship between ChT AL exists, recently has been shown obtained with current optical biometry not very precise needs to be corrected. This study aimed verify if similar correlation also persists this corrected (ALc). Methods: All subjects underwent complete examination, including spectral domain coherence tomography (OCT) enhanced depth image (EDI) mode IOLMaster. After normality check data, correlations ALc were investigated through Pearson coefficient. p values < 0.05 considered statistically significant. Results: In total, 100 eyes 50 healthy patients evaluated. The mean was 24.36 ± 1.23 mm 24.25 1.22 mm. nasal ChT, subfoveal temporal were, respectively, 250.57 93.93 µm, 307.18 101.66 313.72 88.86 µm. A significant negative found comparing both (all r -0.500, all 0.050). stronger = -0.581). Conclusions: Through OCT biometry, we confirmed equal uncorrected AL. On these bases, in studies or protocols, recommend stratifying population according because still present; however, cut-off should changed systematic errors biometry. addition, changes evaluated ALc.

Language: Английский

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Axial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children

Frontiers in Ophthalmology, Journal Year: 2025, Volume and Issue: 4

Published: Jan. 6, 2025

The pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining interrelationships between axial length to corneal curvature radius ratio ( AL/CR ) and choroidal blood flow. This cross-sectional study included 202 eyes from myopic children, categorized into 141 with mild myopia, 47 moderate 14 high myopia. Optical coherence tomography angiography (OCTA) was used measure flow perfusion within a 6 mm × area of macular region, divided nine subareas based on ETDRS partitioning: fovea, nasal side 1, superior temporal inferior 2, 2. Data ocular were collected calculate , equivalent spherical lens power, gender, age gathered for group comparisons, correlation volume analyzed. significantly negatively correlated P<0.001 ). Linear regression mediation analyses indicated that each unit increase region decreased an average 0.421 units. relationship is mediated several factors, serving as key mediator. correlates perfusion, indicating link refractive biological parameters circulation. Myopia ischemic eye condition warrants attention fundus microcirculation changes children.

Language: Английский

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Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(1), P. 18 - 18

Published: Jan. 17, 2025

Purpose: The purpose of this study was to evaluate the correlation between axial length (AL) and retinal oxygen dynamic parameters in adult patients. Methods: This an observational cross-sectional with 79 Chinese adults myopia aged 18 37 years. All participants underwent AL measurements, cycloplegic refraction, other ophthalmic examinations. Additionally, kinetics imaging analysis (ROKIA) system utilized obtain all Simple multiple linear regression tests were used assess various AL. Results: mean age, AL, spherical equivalent (SE) subjects 26.32 ± 5.4 years, 25.78 1.06 mm, −5.13 2.1 diopters (D), respectively. Pearson coefficients among delivery (DO2) metabolism (MO2) −0.44 (95% confidence interval = −0.24 −0.60, P < 0.001), −0.26 −0.04 −0.46, 0.02), group high exhibited lower DO2 higher extraction fraction (OEF) compared moderate myopia, no significant difference observed MO2 two groups. In multivariate analyses adjusting for sex, intraocular pressure (IOP), anterior chamber depth (ACD), a longer significantly associated decreased (standardized coefficient B −0.47, 0.001). Conclusions: Retinal parameters, including MO2, myopic eyes. Patients demonstrated elevated OEF than those myopia. Translational Relevance: that changes as confirmed using novel device quantifies provides new monitoring approach hypoxic diseases.

Language: Английский

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Assessment of retinochoroidal microvasculature in young Chinese Han and Uyghur adults with mild-moderate myopia: An OCTA study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Objective To compare the differences in retinochoroidal microvasculature between Han and Uyghur population with mild-moderate myopia using optical coherence tomography angiography (OCTA) . Method This prospective cross-sectional study included 60 young Chinese subjects.They are divided into two groups according to their ethnics (Han group group). All subjects underwent ophthalmic screening examinations. Retinal choroidal parameters were evaluated swept-source OCTA (SS-OCTA), including retinal thickness, vessel flow density (VFD), foveal avascular zone (FAZ) area, vascularity volume index (CVV CVI) vascular length (VLD). Results had mean ages of 24.93 ± 1.70 25.57 1.36, respectively (p = 0.116). No significant found parameters, VFD FAZ area groups. Compared population, Uyghurs have thicker thickness (P = 0.004), higher CVV 0.002) CVI 0.003). Axial (AL) was negatively associated VFD-SCP, VFD-DCP, VFD-whole retina VFD-choriocapillaris layer based on univariate linear regression analysis. However, only AL after correction for age gender multifactor For subjects, no be age, both Conclusion Young significantly compared matched which may partially elucidate etiological mechanisms underlying reduced prevalence observed within cohort.

Language: Английский

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Artificial intelligence in pathologic myopia: a review of clinical research studies

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 23, 2025

Myopia is a significant global health challenge, with the incidence of pathologic myopia (PM) on rise. PM-related fundus diseases have become leading cause irreversible blindness. Early detection and treatment are crucial for prevention control myopia. Recent advancements in artificial intelligence (AI), particularly machine learning deep algorithms, shown promising results field PM ophthalmology. This review explores latest developments AI technology managing PM, emphasizing its role screening diagnosis, grading classification, predictive assessment. has potential clinical application management, enhancing intelligent, precise, efficient practices.

Language: Английский

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Axial Elongation in Nonpathologic High Myopia: Ocular Structural Changes and Glaucoma Diagnostic Challenges

Asia-Pacific Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: unknown, P. 100123 - 100123

Published: Dec. 1, 2024

Axial elongation continues in highly myopic adult eyes, even the absence of pathologic changes such as posterior staphyloma or chorioretinal atrophy. This ongoing axial leads to structural macular and peripapillary regions, including thinning, reduced vascular perfusion optic disc tilting rotation, among others. These alterations can affect acquisition interpretation optical coherence tomography, tomography angiography fundus photographs, potentially introducing artifacts diminishing accuracy glaucoma diagnosis eyes. In this review, we compared progression patterns across populations with varying demographic characteristics, genetic environmental backgrounds ocular features. We also discussed implications elongation-induced for diagnosing nonpathologic high myopia. Finally, highlighted prospects enhancing diagnostic efficacy populations.

Language: Английский

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Implications of myopia in diagnosis and screening of open angle glaucoma

Current Opinion in Ophthalmology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Rapid increase in the prevalence of myopia has been documented worldwide. Myopia, especially high myopia, is not only an important risk factor for having open angle glaucoma (OAG), but also a strong linking with progression OAG. Since myopic axial length (AXL) elongation associated nonglaucomatous optic nerve head (ONH) and visual field abnormalities, poses challenge differential diagnosis This review provides overview literature studying relationships between AXL-elongation prognosis OAG, functional structural changes eye.

Language: Английский

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