Quantitative Mapping of Posterior Eye Curvature in Children Using Distortion-Corrected OCT: Insights into temporal region morphology
Ophthalmology Science,
Journal Year:
2025,
Volume and Issue:
5(3), P. 100695 - 100695
Published: Jan. 5, 2025
To
explore
the
curvature
distribution
in
posterior
eye
among
school-aged
children
using
distortion-corrected
widefield
OCT
and
its
relationship
with
biometric
variables.
Cross-sectional,
observational
study.
Eighty-eight
children.
A
swept-source-OCT
prototype
system
a
repetition
rate
of
400
kHz
was
used
to
capture
retinal
images
field-of-view
68
×
degrees.
The
acquired
were
corrected
for
distortion
ocular
optical
information
obtained
separately
each
eye.
represented
by
Gaussian
which
derived
from
Bruch's
membrane
segmentation.
mean
assessed
across
4
regions
set
centered
on
fovea,
considering
axial
length
(AL),
refractive
error,
age,
choroidal
thickness
(ChT).
Additionally,
we
identified
entry
site
long
ciliary
artery
(LPCA)
into
choroid.
Local
total
176
eyes
imaged,
7
excluded
due
low
image
quality.
Analysis
169
revealed
bilateral
symmetry
vascular
patterns
curvature.
Significant
correlations
noted
between
AL,
ChT
superior,
macular,
inferior
regions.
However,
temporal
region
exhibited
reversed
correlation
trends.
local
maximum
point
commonly
observed
region,
potentially
linked
LPCA
site.
Our
study
provided
quantitative
analysis
children,
highlighting
region.
Interestingly,
relationships
variables
contradicted
those
other
3
Further
investigation
is
necessary
elucidate
origin
implications
development.
Proprietary
or
commercial
disclosure
may
be
found
Footnotes
Disclosures
at
end
this
article.
Language: Английский
Advancements in age-related macular degeneration treatment: From traditional anti-VEGF to emerging therapies in gene, stem cell, and nanotechnology
Biochemical Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 116902 - 116902
Published: March 1, 2025
Language: Английский
Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration
Eye,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 15, 2025
Language: Английский
New findings on the unique curvature region in the posterior eye using widefield OCT
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 23, 2024
Abstract
This
study
aimed
to
explore
the
curvature
distribution
in
posterior
eye
among
school-aged
children
using
distortion-corrected
optical
coherence
tomography
(OCT)
images
and
its
relationship
with
biometric
variables
choroidal
vascular
parameters.
We
conducted
a
prospective,
observational,
cross-sectional
involving
88
aged
6
15
years.
After
comprehensive
ocular
examinations,
widefield
OCT
volumes
68×68
degrees
were
captured
utilizing
high-speed,
wide-field
SS-OCT
prototype
system.
The
distortion
of
volume
was
geometricallycorrected,
Gaussian
maps
derived
from
Bruch’s
membrane
segmentation
lines.
mean
assessed
across
four
square
regions
19×19
each,
where
axial
length
(AL),
refractive
error,
age,
thickness
(ChT)
statistically
analyzed.
Additionally,
entry
site
long
ciliary
artery
(LPCA)
into
choroid
same
volume.
Analysis
169
demonstrated
bilateral
symmetry
patterns
curvature.
Mean
exhibited
asignificant
correlation
AL,
ChT
superior,
macular,
inferior
regions.
Conversely,
temporal
region
showed
weak
negative
correlation.
Notably,
local
maximum
point
commonly
observed
for
first
time
this
study,
suggesting
potential
reversal
area.
rationale
observation
remains
unclear;
however,
proximity
may
suggest
link.
Further
investigation
is
necessary
elucidate
origins
implications
these
findingsfor
development.
Language: Английский
Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(12), P. 7 - 7
Published: Oct. 4, 2024
Outer
retinal
band
integrity
strongly
predicts
late
age-related
macular
degeneration
(AMD).
However,
it
is
often
assessed
subjectively
as
"continuity"
using
inconsistent
definitions.
Alternatively,
"curvature"
of
the
outer
bands
a
quantitative
metric
that
correlates
with
AMD
biomarkers
and
can
screen
for
intermediate
AMD.
We
evaluated
prognostic
ability
pigment
epithelium
(RPE)
ellipsoid
zone
(EZ)
curvature
against
continuity,
pigmentary
abnormalities,
reticular
pseudodrusen,
drusen
volume.
Language: Английский