Polyoxyethylene and Polypropylene Emulsification Enhances Retinol Palmitate Efficacy in Corneal Wound Healing DOI Creative Commons

H. Horiuchi,

Keisuke Watanabe, Hiroshi Iijima

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Retinol palmitate (VApal), an active ingredient in ophthalmic solution, has been reported to repair corneal injuries. Additionally, it suggested that the efficacy of VApal is enhanced by a specific surfactant, polyoxyethylene-polypropylene [EO100PO70EO100 (EOPO)]. We aimed determine wound healing comparison hyaluronic acid (HA), carboxymethyl cellulose (CMC) and hydroxypropyl methylcellulose (HPMC) used over-the-counter solutions whether could be EOPO compared widely polyoxyethylene hydrogenated castor oil 60 (HCO60). To evaluate or emulsified with we performed assay using epithelial cells monolayer (n = 4) 3D culture 6). Wound closure rates were calculated each time, was time reach 50% rate (ET50). The ET50 values VApal, HA, CMC HPMC approximately 17.31 h, 26.99 28.98 h 26.01 respectively. HCO60 34.49 43.31 In conclusion, more beneficial than other ingredients for healing. can instead HCO60.

Language: Английский

Polyoxyethylene and Polypropylene Emulsification Enhances Retinol Palmitate Efficacy in Corneal Wound Healing DOI Creative Commons

H. Horiuchi,

Keisuke Watanabe, Hiroshi Iijima

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Retinol palmitate (VApal), an active ingredient in ophthalmic solution, has been reported to repair corneal injuries. Additionally, it suggested that the efficacy of VApal is enhanced by a specific surfactant, polyoxyethylene-polypropylene [EO100PO70EO100 (EOPO)]. We aimed determine wound healing comparison hyaluronic acid (HA), carboxymethyl cellulose (CMC) and hydroxypropyl methylcellulose (HPMC) used over-the-counter solutions whether could be EOPO compared widely polyoxyethylene hydrogenated castor oil 60 (HCO60). To evaluate or emulsified with we performed assay using epithelial cells monolayer (n = 4) 3D culture 6). Wound closure rates were calculated each time, was time reach 50% rate (ET50). The ET50 values VApal, HA, CMC HPMC approximately 17.31 h, 26.99 28.98 h 26.01 respectively. HCO60 34.49 43.31 In conclusion, more beneficial than other ingredients for healing. can instead HCO60.

Language: Английский

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