High-resolution optical coherence tomography in pigmented choroidal lesions

International Journal of Retina and Vitreous, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 27, 2025

Abstract Purpose Evaluating High-Resolution Optical Coherence Tomography (HR-OCT) versus standard spectral domain OCT in pigmented choroidal lesions. Methods We screened a total of 40 subjects with Lesions were imaged on HR-OCT and devices without enhanced depth imaging (EDI) mode. Images graded for qualitative quantitative aspects, like choriocapillaris compression width, reflectivity thickness, amongst others. Results 32 the could be included image analysis, rest excluded due to insufficient imaging. EDI mode allowed visualization posterior extent 11 lesions (11/32 = 34.4%) six (6/32; 18.8%), four (4/30; 13.3%), five cases (5/30; 16.7%) normal ( n 32), 30) 30), respectively, albeit not significantly different. Choriocapillaris was evident 10 equally visible all modes. Mean thickness ranged from 11.6 13.9 microns (SD range 3.84–4.33), compressed similarly mean 7.1 7.8 2.20–3.55). Image quality declined towards periphery three out modes p 0.0077 0.29). Conclusions may provide better visibility retinal structures lesions, although is reduced attempting peripheral Translational relevance The prototype offers insights into clinical features that are apparent conventional This supports development HR-OCTolution devices.

Language: Английский

Topographic Analysis of Two-Wavelength Autofluorescence Supports Higher Macular Xanthophyll Pigment in AMD Than Aging: ALSTAR2 Baseline

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(3), P. 61 - 61

Published: March 31, 2025

Purpose: To advance metabolic imaging of the high-risk macula lutea by quantifying topography macular pigment optical density (MPOD), measured with two-wavelength autofluorescence (2WAF), and quantitative (short-wavelength) (qAF) intensity, which share same signal source cross-retinal light path, in aging, early (e), intermediate (i) age-related degeneration (AMD). Methods: 2WAF qAF images 384 pseudophakic eyes 230 persons (mean age, 74.2 ± 5.7 years; 145 female) from ALSTAR2 (AREDS 9-step classification: 170, normal; 118, eAMD; 96 iAMD) were shown as maps (intensity, z-score) meridian plots. Correlations determined Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Results: MPOD was higher central subfield (P < 0.01) iAMD compared to eAMD normal eyes, lower inner ring (both P AMD eyes. differed along horizontal versus vertical meridians, depending on disease stage. Pixel-level z-score plots showed distinct annuli alternating levels anchored foveal center, unrelated qAF. Across subfield, high associated low all stages (r = −0.47, r −0.42; 0.001). In ring, correlations significant for only −0.31, 0.004 −0.22, ≤ 0.001, respectively). Conclusions: New analytics support previously reported especially ring. differ disease-stage–related correlations, supporting independent use lutea.

Language: Английский