Differential impact of 0.01% and 0.05% atropine eye drops on visual performance in young adults

Ophthalmic and Physiological Optics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Purpose The onset and progression of myopia can occur during adulthood, suggesting that should be managed in young adults. Low‐concentration atropine eye drops have shown promising efficacy control. This study aimed to evaluate the impact 0.01% 0.05% on visual performance university students. Methods Twenty‐six myopic students aged 18–30 years received random order. Atropine were administered once a night both eyes for 14 days, with minimum 14‐day washout period between concentrations. Visual assessments, including modulation transfer function (MTF) cut‐off, Strehl ratio (SR), objective scattering index, contrast sensitivity (CS) glare disability, conducted 1, 2, 7 days after administration corresponding time points cessation. A questionnaire was used ocular general symptoms. Results After 1 day treatment atropine, MTF cut‐off ( β = −8.75, p < 0.001) SR −0.05, decreased significantly their lowest levels. area under log CS also (all 0.05) drops, especially mesopic condition, reached its point −0.20, 0.001). However, all parameters returned baseline levels 2 weeks stopped > 0.05). Additionally, 40.91% adults reported experiencing excessive daytime sleepiness nocturnal use. Treatment had minimal effects subjective Conclusions Administration significant but temporary effect adult patients, whereas effect.

Language: Английский

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A deep learning-assisted automatic measurement of tear meniscus height on ocular surface images and its application in myopia control

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 11, 2025

Purpose Modalities for myopia control, such as orthokeratology, repeated low-intensity red light (RLRL) treatment, and low-concentration atropine, have become popular topics. However, the effects of these three modalities on ocular surface health remain unclear. The tear meniscus height (TMH), a crucial criterion evaluating diagnosing dry eye, is conventionally measured via manual demarcation images, which inefficient involves subjective judgment. Therefore, this study sought to establish deep learning model automatic TMH measurement images improve efficiency accuracy initial screening eye associated with control modalities. Methods To model, 1,200 captured an OCULUS Keratograph 5M were collected. area image was initially marked by one experienced ophthalmologist verified other. whole dataset divided into training set (70%), validation (20%), test (10%), external (100 images) construction. applied imaging data from previous clinical trials using RLRL therapy, 0.01% atropine control. TMHs at follow-ups automatically model. Results Two hundred iterations performed At 124th iteration, IoU peaked 0.913, parameters saved testing process. 0.928 during testing. AUC ROC curve 0.935, R2 linear regression analysis 0.92. good performance comprehensive warrants its application in There no significant changes follow-up period after treatment RLRL, or atropine. Conclusion A established 5M-captured images. This demonstrated high accuracy, great consistency measurements, applicability

Language: Английский

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Efficacy and Safety of 0.03% Atropine Eye Drops in Controlling Myopia Progression: A One-Year Prospective Clinical Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3218 - 3218

Published: May 30, 2024

Objective: To investigate the efficacy and safety of one-year treatment with 0.03% atropine eye drops for slowing myopia progression among children aged 6-12 years. Methods: Healthy Caucasian years cycloplegic spherical equivalent (SE) from -1.0 D to -5.0 astigmatism anisometropia ≤1.5 were included. Changes in mean axial length (AL) objective SE as well changes intraocular pressure (IOP), central corneal thickness (CCT), anterior chamber depth (ACD) lens (LT) assessed group control baseline through 1-year follow-up. The proportion participants showing <0.5 each any potential side effects evaluated. Results: study involved 31 patients 41 group. Administration 1 year resulted a change -0.34 (0.44) D/year, significantly lower than -0.60 (0.50) D/year observed (p = 0.024). AL was 0.19 (0.17) mm group, compared 0.31 (0.20) 0.015). There no significant differences IOP, CCT LT between groups (all p ≥ 0.05). had greater increase ACD In total, 64.5% showed contrast 39.0% 0.032). Adverse events reported 13 (35.0%) out 37 leading discontinuation six (16.0%) cases. None adverse severe. Conclusions: Despite higher incidence events, effectively slowed over 1-year.

Language: Английский

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Short-term effects of ophthalmic topical 0.01% atropine on the ocular surface, pupil size, and subsequent subjective quality of vision in young myopic Chinese adults

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 5, 2024

Daily use of low concentrations atropine is recommended for children undergoing myopia control therapy. While the benefits controlling progression have been confirmed, potential unwanted side effects on ocular surface, pupil size, and quality vision following administration 0.01% not investigated.

Language: Английский

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Knowledge, attitude, and practice of non-ophthalmic medical staff toward myopia-related fundus lesions

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 23, 2024

This study assessed the knowledge, attitude, and practice (KAP) of non-ophthalmic medical staff towards myopia-related fundus lesions. multicenter, cross-sectional enrolled Suining City between January May 2023 using a self-designed questionnaire. A total 505 (93.19%) valid questionnaires were included. Their mean KAP scores 8.10 ± 2.32 (range: 0–12), 20.27 2.68 0–24), 17.77 5.04 0–28), respectively. Structural equation modeling indicated that knowledge has positive effect on attitude (β = 0.307, P < 0.001), 0.604, 0.001). Moreover, higher degree myopia exhibited 0.510, Nurses other showed negative − 0.706, 0.001) compared to doctors. Working in secondary tertiary public hospitals, as well private demonstrated 1.963, those working primary hospitals. Non-ophthalmic moderate attitudes, practices toward The myopia, doctors vs. staff, hospital level influence staff.

Language: Английский

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