Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Resveratrol, a polyphenolic compound commonly found in natural plants and fruits, exhibits potential preventing optic nerve damage glaucoma, as indicated by several animal studies. However, there is presently dearth of relevant evidence available for comprehensive summarization. In this study, we conducted an extensive search across 7 electronic databases, encompassing all pertinent studies systematic review meta-analysis. Methodological quality was evaluated using SYRCLE's bias risk tool, with statistical analysis performed Stata 17.0. The primary outcome measures included the survival retinal ganglion cells thickness. 30 revealed that resveratrol can enhance expression Sirtuin 1(SIRT1) protein tissue (SMD: 3.00, 95% CI: 2.46, 3.53, P = 0.095), boost rate 4.33, 3.28, 5.38, < 0.05), decelerate thinning thickness 4.26, 2.77, 5.75, visual function. Its mechanism action may involve suppression pro-inflammatory cytokine levels cell apoptosis. Resveratrol emerges promising agent mitigating glaucoma-related damage. given research models utilized study not fully reflect intricate scenarios multiple coexisting diseases clinical settings, administration methods differ from those practice, future should aim to provide higher facilitate translation these findings. identifier [CRD42024535673].

Language: Английский

Neurofilament Isoform Promoter-Driven Expression of Therapeutic Genes

Translational Vision Science & Technology, Journal Year: 2024, Volume and Issue: 13(9), P. 30 - 30

Published: Sept. 30, 2024

Language: Английский