Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41267 - e41267

Published: Dec. 18, 2024

Language: Английский

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What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 9, 2023

Abstract Background Neutrophil extracellular traps (NETs), have repeatedly been related to COVID-19 severity and mortality. However, there is no consensus on their quantification, are scarce data evolution during the disease. We studied circulating NET markers in patients with throughout hospitalization. Methods prospectively included 93 (201 blood samples), evaluating disease 3 evolutionary phases (viral, early, late inflammation). Of these, 72 had 180 samples various phases. also evaluated 55 controls similar age, sex comorbidities. measured 4 markers: cfDNA, CitH3, MPO-DNA NE-DNA complexes; as well neutrophil-related cytokines IL-8 G-CSF. Results The group higher CitH3 (p = 0.022), MPO-DNA, < 0.001) than hospitalisation. cfDNA was only marker clearly severity, it remained non-survivors Only an independent risk factor for mortality need intensive care. count, IL-8, G-CSF were significantly severity. showed significant correlations all across grades, they days 10–16 of those who died. Correlations among other lower expected. Conclusions Although NETs present hospitalization, markers, except little or association activity neutrophil count associated better reflected formation. appeared be more overall tissue damage; previous widespread use this could overestimated relationship between Currently, limitations accurate measurement that make difficult assess its true role pathogenesis.

Language: Английский

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Course and outcome of chilblain‐like acral lesions during COVID‐19 pandemic

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2022, Volume and Issue: 37(1)

Published: Sept. 23, 2022

Language: Английский

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Aspirin Therapy in COVID-19: Prevention of NETosis

Archivos de Bronconeumología, Journal Year: 2022, Volume and Issue: 59(2), P. 129 - 129

Published: Oct. 13, 2022

Language: Английский

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Statin Therapy in COVID-19: Inhibition of NETosis

Journal of General Internal Medicine, Journal Year: 2022, Volume and Issue: 38(4), P. 1077 - 1077

Published: Nov. 22, 2022

Language: Английский

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