Metabolites,
Journal Year:
2024,
Volume and Issue:
14(6), P. 300 - 300
Published: May 25, 2024
Chronic
kidney
disease
(CKD)
impacts
14%
of
adults
in
the
United
States,
and
African
American
(AA)
individuals
are
disproportionately
affected,
with
more
than
3
times
higher
risk
failure
as
compared
to
White
individuals.
This
study
evaluated
effects
base-producing
fruit
vegetables
(FVs)
on
cardiorenal
outcomes
AA
persons
CKD
hypertension
(HTN)
a
low
socioeconomic
area.
The
“Cardiorenal
Protective
Diet”
prospective
randomized
trial
6-week,
community-based
FV
intervention
waitlist
control
(WL)
91
(age
=
58.3
±
10.1
years,
66%
female,
48%
income
≤
USD
25K).
Biometric
metabolomic
variables
were
collected
at
baseline
6
weeks
post-intervention.
change
health
for
both
groups
was
statistically
insignificant
(p
>
0.05),
though
small
reductions
albumin
creatinine
ratio,
body
mass
index,
total
cholesterol,
systolic
blood
pressure
observed
group.
Metabolomic
profiling
identified
key
markers
<
including
C3,
C5,
1-Met-His,
kynurenine,
PC
ae
38:5,
choline,
indicating
function
decline
WL
Overall,
delivering
directed
protective
diet
improved
HTN.
Additionally,
may
serve
prognostic
technique
early
identification
biomarkers
indicators
worsening
increased
CVD
risk.
BMC Nephrology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: May 30, 2024
Protein
carbamylation,
a
post-translational
protein
modification
primarily
driven
by
urea,
independently
associates
with
adverse
clinical
outcomes
in
patients
CKD.
Biomarkers
used
to
quantify
carbamylation
burden
have
mainly
included
carbamylated
albumin
(C-Alb)
and
homocitrulline
(HCit,
lysine).
In
this
study,
we
aimed
compare
the
prognostic
utility
of
these
two
markers
order
facilitate
comparisons
existing
studies
employing
either
marker
alone,
inform
future
studies.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(7), P. 879 - 879
Published: July 24, 2023
Brazil
has
the
second-highest
COVID-19
death
rate
worldwide,
and
Rio
de
Janeiro
is
among
states
with
highest
in
country.
Although
vaccine
coverage
been
achieved,
it
anticipated
that
will
transition
into
an
endemic
disease.
It
concerning
molecular
mechanisms
underlying
clinical
evolution
from
mild
to
severe
disease,
as
well
leading
long
COVID-19,
are
not
yet
fully
understood.
NMR
MS-based
metabolomics
were
used
identify
metabolites
associated
pathophysiology
disease
outcome.
Severe
cases
(n
=
35)
enrolled
two
reference
centers
within
72
h
of
ICU
admission,
alongside
12
non-infected
control
subjects.
patients
grouped
survivors
18)
non-survivors
17).
Choline-related
metabolites,
serine,
glycine,
betaine,
reduced
indicating
dysregulation
methyl
donors.
Non-survivors
had
higher
levels
creatine/creatinine,
4-hydroxyproline,
gluconic
acid,
N-acetylserine,
liver
kidney
dysfunction.
Several
changes
greater
women;
thus,
patients'
sex
should
be
considered
pandemic
surveillance
achieve
better
stratification
improve
outcomes.
These
metabolic
alterations
may
useful
monitor
organ
(dys)
function
understand
acute
possibly
post-acute
syndromes.
