Metabolites,
Journal Year:
2024,
Volume and Issue:
14(6), P. 300 - 300
Published: May 25, 2024
Chronic
kidney
disease
(CKD)
impacts
14%
of
adults
in
the
United
States,
and
African
American
(AA)
individuals
are
disproportionately
affected,
with
more
than
3
times
higher
risk
failure
as
compared
to
White
individuals.
This
study
evaluated
effects
base-producing
fruit
vegetables
(FVs)
on
cardiorenal
outcomes
AA
persons
CKD
hypertension
(HTN)
a
low
socioeconomic
area.
The
“Cardiorenal
Protective
Diet”
prospective
randomized
trial
6-week,
community-based
FV
intervention
waitlist
control
(WL)
91
(age
=
58.3
±
10.1
years,
66%
female,
48%
income
≤
USD
25K).
Biometric
metabolomic
variables
were
collected
at
baseline
6
weeks
post-intervention.
change
health
for
both
groups
was
statistically
insignificant
(p
>
0.05),
though
small
reductions
albumin
creatinine
ratio,
body
mass
index,
total
cholesterol,
systolic
blood
pressure
observed
group.
Metabolomic
profiling
identified
key
markers
<
including
C3,
C5,
1-Met-His,
kynurenine,
PC
ae
38:5,
choline,
indicating
function
decline
WL
Overall,
delivering
directed
protective
diet
improved
HTN.
Additionally,
may
serve
prognostic
technique
early
identification
biomarkers
indicators
worsening
increased
CVD
risk.
Kidney International Reports,
Journal Year:
2024,
Volume and Issue:
9(9), P. 2718 - 2726
Published: June 29, 2024
Uremic
toxins
contributing
to
increased
risk
of
death
remain
largely
unknown.
We
used
untargeted
metabolomics
identify
plasma
metabolites
associated
with
mortality
in
patients
receiving
maintenance
hemodialysis.
Identification
of
the
individuals
having
impaired
kidney
function
is
essential
in
preventing
complications
this
disease.
We
measured
1
009
metabolites
at
baseline
study
10
159
Finnish
men
METSIM
cohort
and
associated
with
estimated
glomerular
filtration
rate
(eGFR).
A
total
7
090
participated
12-year
follow-up
study.
Non-targeted
metabolomics
profiling
was
performed
Metabolon,
Inc.
(Morrisville,
NC,
USA)
on
EDTA
plasma
samples
obtained
after
overnight
fasting.
applied
Liquid
chromatography-mass
spectrometry
(LC-MS/MS)
to
identify
(the
Metabolon
DiscoveryHD4
platform).
association
analyses
between
eGFR
using
linear
regression
adjusted
for
confounding
factors.
found
108
significantly
a
decrease
eGFR,
28
them
were
novel
including
12
amino
acids,
8
xenobiotics,
5
lipids,
nucleotide,
peptide,
partially
characterized
molecule.
The
most
significant
associations
five
N-acetylmethionine,
N-acetylvaline,
gamma-carboxyglutamate,
3-methylglutaryl-carnitine,
pro-line.
identified
decreased
cohort.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 4, 2023
Abstract
Brazil
has
the
second
highest
COVID-19
death
rate
while
Rio
de
Janeiro
is
among
states
with
in
country.
Although
effective
vaccines
have
been
developed,
it
anticipated
that
ongoing
pandemic
will
transition
into
an
endemic
state.
Under
this
scenario,
worrisome
underlying
molecular
mechanisms
associated
disease
clinical
evolution
from
mild
to
severe,
as
well
leading
long
COVID
are
not
yet
fully
understood.
In
study,
1
H
Nuclear
Magnetic
Resonance
spectroscopy
and
Liquid
Chromatography-Mass
spectrometry-based
metabolomics
were
used
identify
potential
pathways
metabolites
involved
pathophysiology
outcome.
We
prospectively
enrolled
35
severe
RT-PCR
confirmed
cases
within
72
hours
intensive
care
unit
admission,
between
April
July
2020
two
reference
centers
Janeiro,
12
samples
non-infected
control
subjects.
Of
patients,
18
survivors
17
non-survivors.
observed
patients
had
their
plasma
metabolome
significantly
changed
if
compared
lower
levels
of
glycerophosphocholine
other
choline-related
metabolites,
serine,
glycine,
betaine,
indicating
a
dysregulation
methyl
donors
one-carbon
metabolism.
Importantly,
non-survivors
higher
creatine/creatinine,
4-hydroxyproline,
gluconic
acid
N
-acetylserine
controls,
reflecting
uncontrolled
inflammation,
liver
kidney
dysfunction,
insulin
resistance
these
patients.
Lipoprotein
dynamics
amino
metabolism
also
altered
Several
changes
greater
women,
thus
patient’s
sex
should
be
considered
surveillance
achieve
better
stratification
improve
outcomes.
The
incidence
outcome
after
hospital
discharge
very
high
Brazil,
metabolic
alterations
may
monitor
patients’
organs
tissues
understand
long-post
COVID-19.
Metabolic Syndrome and Related Disorders,
Journal Year:
2024,
Volume and Issue:
22(7), P. 525 - 550
Published: May 14, 2024
Introduction:
Chronic
kidney
disease
(CKD)
is
associated
with
metabolic
disorders.
However,
the
evidence
for
causality
of
circulating
metabolites
to
promote
or
prevent
CKD
still
lacking.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(6), P. 300 - 300
Published: May 25, 2024
Chronic
kidney
disease
(CKD)
impacts
14%
of
adults
in
the
United
States,
and
African
American
(AA)
individuals
are
disproportionately
affected,
with
more
than
3
times
higher
risk
failure
as
compared
to
White
individuals.
This
study
evaluated
effects
base-producing
fruit
vegetables
(FVs)
on
cardiorenal
outcomes
AA
persons
CKD
hypertension
(HTN)
a
low
socioeconomic
area.
The
“Cardiorenal
Protective
Diet”
prospective
randomized
trial
6-week,
community-based
FV
intervention
waitlist
control
(WL)
91
(age
=
58.3
±
10.1
years,
66%
female,
48%
income
≤
USD
25K).
Biometric
metabolomic
variables
were
collected
at
baseline
6
weeks
post-intervention.
change
health
for
both
groups
was
statistically
insignificant
(p
>
0.05),
though
small
reductions
albumin
creatinine
ratio,
body
mass
index,
total
cholesterol,
systolic
blood
pressure
observed
group.
Metabolomic
profiling
identified
key
markers
<
including
C3,
C5,
1-Met-His,
kynurenine,
PC
ae
38:5,
choline,
indicating
function
decline
WL
Overall,
delivering
directed
protective
diet
improved
HTN.
Additionally,
may
serve
prognostic
technique
early
identification
biomarkers
indicators
worsening
increased
CVD
risk.
