The Role of Long Non-Coding RNAs in Cardiovascular Diseases: A Comprehensive Review DOI Creative Commons
Xuena Xie,

Mei‐Wen Huang,

Shudong Ma

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 158 - 187

Published: Dec. 28, 2024

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, molecular mechanisms underlying CVDs not yet fully understood. For decades, protein-coding genes have been focus CVD research. However, recent genomics highlighted importance long non-coding RNAs (lncRNAs) cardiovascular health disease. Changes lncRNA expression specific tissues may result from various internal or external factors, tissue damage, organ dysfunction, In this review, we provide a comprehensive discussion regulatory lncRNAs their roles pathogenesis progression CVDs, such as coronary heart disease, atherosclerosis, failure, arrhythmias, cardiomyopathies, diabetic cardiomyopathy, explore potential therapeutic targets diagnostic biomarkers.

Language: Английский

Identification of SERPINE1 as a therapeutic target in hypertrophic cardiomyopathy via bioinformatics analysis and experimental validation DOI
Ahmed Al‐Maamari,

Marwa Sultan,

Shanshan Ding

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102150 - 102150

Published: Jan. 1, 2025

Language: Английский

Citations

1
Impact of microRNAs and long non-coding RNAs in skeletal and cardiac muscle DOI Creative Commons
Gabriela Placoná Diniz, Joanne Chan, John D. Mably

et al.

Current Opinion in Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 100829 - 100829

Published: April 1, 2025

Language: Английский

Citations

0
The mechanisms and application prospects of exosomes in acute myocardial infarction DOI
Peng Zhou, Jia Zhang, Leilei Zhang

et al.

Extracellular Vesicle, Journal Year: 2025, Volume and Issue: 5, P. 100073 - 100073

Published: April 7, 2025

Language: Английский

Citations

0
Diagnostic and prognostic values of HCG15 and morrbid in acute myocardial infarction DOI Creative Commons
Min Huang, Bohua Wu, Ou Xu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Background Acute myocardial infarction (AMI) represents the gravest manifestation of ischemic heart disease, with primary cause mortality and morbidity worldwide. Although timely accurate diagnosis AMI is crucial in clinical practice, they are impeded by limitation current biomarkers. We aimed to explore potential predictive value two novel long non-coding RNA (lncRNA) HCG15 Morrbid prognosis. Method measured lncRNA levels blood samples 412 patients 111 healthy volunteers RT-PCR method. Receiver operating characteristic (ROC) curves were plotted access diagnostic selected lncRNAs. Restricted cubic splines (RCS) Kaplan-Meier method utilized examine lncRNAs diagnosis. Result ROC identified an acceptable (AUC for HCG15: 0.937; AUC Morrbid: 0.940). RCS analysis revealed cut-off 3.6 4.0 have a good MACCE within 12 months once was diagnosed ( p -value = 0.025; < 0.0001). Conclusion confirmed as promising biomarkers both prognosis this study. Additionally, their importance application real-world practice underlying mechanisms remain be explored.

Language: Английский

Citations

1
MicroRNA-330-5p Mediates the TDRG1-Regulated Myocardial Inflammation and Apoptosis after Myocardial Infarction by Inhibiting MAPK1 DOI Open Access

Wenjing Wang,

Yanhui Ni,

Guangyun Cao

et al.

International Heart Journal, Journal Year: 2024, Volume and Issue: 65(4), P. 693 - 702

Published: July 30, 2024

Acute myocardial infarction (AMI) is a cardiovascular illness with the highest disability and mortality rates worldwide. This study aimed to estimate mechanism of TDRG1 in damage.qRT-PCR was used levels TDRG1. After establishing hypoxia/reoxygenation (H/R) model, inflammation assessed by qRT-PCR, oxidation detected commercial kits, apoptosis estimated qRT-PCR flow cytometry. The luciferase intensity RNA immunoprecipitation assay were for identification target relationship. functional enrichment unveiled GO Kyoto Encyclopedia Genes Genomes (KEGG). protein interaction conducted screening key genes.The expression elevated negatively correlated miR-330-5p serum AMI patients. TDRG1/miR-330-5p axis regulated inflammation, oxidation, viability HL-1 cells induced H/R. KEGG analyses indicate that 76 overlapping targets primarily involved focal adhesion, calmodulin binding, ErbB Rap1 signaling pathways. MAPK1 top gene miR-330-5p.TDRG1/miR-330-5p could participate regulation H/R-induced cardiomyocytes.

Language: Английский

Citations

0
Current Insights and Future Directions of LncRNA Morrbid in Disease Pathogenesis DOI Creative Commons
Haiqiong Yang, Jiali Gao, Zaiyong Zheng

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36681 - e36681

Published: Aug. 23, 2024

Language: Английский

Citations

0
Bioinformatics analysis combined with whole transcriptome sequencing to explore key genes and regulatory mechanisms of acute type A aortic dissection DOI Creative Commons

Libin Yang,

Xu Yang, Lichun Xie

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Abstract Traditional treatments for acute type A aortic dissection (ATAAD) are ineffective, and its mechanisms unclear. Whole transcriptome sequencing of ATAAD healthy control (HC) tissues identified differentially expressed mRNAs (DE-mRNAs), miRNAs, long non-coding RNAs (lncRNAs), circular (circRNAs). Target genes were determined by intersecting DE-mRNAs with ATAAD-related genes. Key analyzed using protein-protein interaction (PPI) analysis, machine learning, various functional analyses including gene set enrichment analysis (GSEA), Ingenuity Pathway Analysis (IPA), immune cell infiltration analysis. Regulatory networks potential drugs targeting key also explored. Out 1,662 520 module genes, 177 target related to hypoxia response energy metabolism identified. GPD1L, PFKFB4, PKM found, involved in the hypoxia-inducible factor 1-alpha (HIF-1α) signaling pathway, which is crucial angiogenesis. Hub miRNAs hsa-miR-224-3p hsa-miR-199b-5p, C15orf56 noted their regulatory roles. Phosphoaminophosphonic Acid-Adenylate Ester could be a drug PFKFB4. significantly influencing angiogenesis through HIF-1α pathway.

Language: Английский

Citations

0
The Role of Long Non-Coding RNAs in Cardiovascular Diseases: A Comprehensive Review DOI Creative Commons
Xuena Xie,

Mei‐Wen Huang,

Shudong Ma

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 158 - 187

Published: Dec. 28, 2024

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, molecular mechanisms underlying CVDs not yet fully understood. For decades, protein-coding genes have been focus CVD research. However, recent genomics highlighted importance long non-coding RNAs (lncRNAs) cardiovascular health disease. Changes lncRNA expression specific tissues may result from various internal or external factors, tissue damage, organ dysfunction, In this review, we provide a comprehensive discussion regulatory lncRNAs their roles pathogenesis progression CVDs, such as coronary heart disease, atherosclerosis, failure, arrhythmias, cardiomyopathies, diabetic cardiomyopathy, explore potential therapeutic targets diagnostic biomarkers.

Language: Английский

Citations

0