Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment DOI Creative Commons
Su Yin Lim,

Suzanah C. Boyd,

Russell J. Diefenbach

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 28, 2025

MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of miRNAs may parallel the cellular composition dynamic activity within microenvironment reveal systemic immune responses. functional complexity miRNAs-where a single miRNA regulate multiple messenger RNAs (mRNAs) to fine tune fundamental processes, mRNA be targeted by miRNAs-underscores their broad significance impact. However, this poses challenges for translating research into clinical practice. In melanoma, specific signatures have shown notable diagnostic, prognostic predictive value, with lineage-specific immune-related frequently identified markers. review, we explore role potential in highlight current status advances required translate therapeutic opportunities.

Language: Английский

Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment DOI Creative Commons
Su Yin Lim,

Suzanah C. Boyd,

Russell J. Diefenbach

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 28, 2025

MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of miRNAs may parallel the cellular composition dynamic activity within microenvironment reveal systemic immune responses. functional complexity miRNAs-where a single miRNA regulate multiple messenger RNAs (mRNAs) to fine tune fundamental processes, mRNA be targeted by miRNAs-underscores their broad significance impact. However, this poses challenges for translating research into clinical practice. In melanoma, specific signatures have shown notable diagnostic, prognostic predictive value, with lineage-specific immune-related frequently identified markers. review, we explore role potential in highlight current status advances required translate therapeutic opportunities.

Language: Английский

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