Research trends of glioma-related epilepsy: A bibliometric analysis from 2004 to 2023 DOI Creative Commons

Ruofei Liang,

Chaosu Hu, Haiyu Li

et al.

Journal of Central Nervous System Disease, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 16, 2024

Glioma-related epilepsy (GRE) is a hotspot in recent years and there remains many urgent unsolved issues. This study aimed to conduct bibliometric analysis on GRE research over the past 2 decades. We collected scientific outputs relating Web of Science Core Collection (WoSCC) from 2004 2023 conducted visual using VOSviewer Microsoft Excel. A total 2697 publications were retrieved with an increasing trend 20 years. The USA ranked first publication number, citation H-index. Institut National de la Sante et Recherche Medicale (Inserm) was institution most publications. In field GRE, core journals Journal Neurosurgery, Epilepsia Neurology. Duffau, Hugues author papers citations, highest Co-occurrence revealed that latest focus awake craniotomy, immunotherapy, cognitive impairment, basic pathogenesis, particular emphasis IDH1 mutation. intended gain deeper understanding current global identify hotspots, as well provide theoretical reference for further studies.

Language: Английский

Immunological factors in pediatric generalized and focal epilepsy: interplay with anti-seizure medications DOI Creative Commons
Dongyan Zhang,

Hongguang Sun

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 17, 2025

Pediatric epilepsy presents challenges in treatment optimization, with a significant proportion of patients experiencing inadequate seizure control despite anti-seizure medications (ASMs) therapy. Recent research has indicated the involvement neuroinflammation and immune-mediated mechanisms pathogenesis, suggesting potential interplay between immunological factors ASMs responsiveness. This study aimed to investigate role pediatric generalized, focal their interaction understand influence on outcomes. A retrospective cohort was conducted involving 136 patients, categorized into Anti-seizure Insensitive Group (n = 67) Sensitive 69). Immunoglobulin levels factors, including cytokines, were assessed before treatment. Seizure characteristics also analyzed. Associations characteristics, sensitivity evaluated. The revealed differences interleukin-6 (IL-6), IL-1β IL-10 levels, insensitive sensitive groups. Furthermore, frequency, drug-resistant seizures, severity, seizure-free period, status epilepticus all demonstrated correlations ASMs, negative for positive period epilepticus. highlights complex immune function, mechanisms, underscoring need comprehensive understanding modulation drug response epilepsy. Not applicable.

Language: Английский

Citations

0
Optimization of seizure prevention by cannabidiol (CBD) DOI Creative Commons
Bidhan Bhandari,

Sahar Emami Naeini,

Sholeh Rezaee

et al.

Translational Neuroscience, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 1, 2025

Cannabidiol (CBD) is one of the most prominent non-psychotropic cannabinoids with known therapeutic potentials. Based on its anti-seizure efficacy, first cannabis derived pharmaceutical grade CBD-based medication was approved in USA 2018 for treatment seizures patients 2 years and older. Despite effectiveness reducing seizures, there remain several major questions optimization CBD therapy epilepsy such as optimal dosage, composition, route delivery, which are main objective this current study. We evaluated antiseizure effects through different compositions, routes dosages a pre-clinical model. used kainic acid-induced model C57BL/6 mice, treated them placebo and/or inhalation, oral, injection (intraperitoneal) routes. broad spectrum (inhaled intraperitoneal) vs isolate formulations. employed Racine scaling system to evaluate severity flow cytometry measuring immune biomarkers neurotrophic factors, histologic analysis examine compare groups. Our findings showed that all forms reduced severity. Among combination tested, via inhalation effective epileptic (p < 0.05) compared other treatments. data suggest formulations affect efficacy prevention seizures. Inhaled potential superior effect delivery warrants further research.

Language: Английский

Citations

0
Neurotransmitter power plays: the synaptic communication nexus shaping brain cancer DOI Creative Commons
Jayanta Mondal, Jason T. Huse

Acta Neuropathologica Communications, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 30, 2025

Gliomas and brain metastases are notorious for their dismal prognosis low survival rates, a challenge exacerbated by our incomplete grasp of the complex dynamics that govern cancers. Recently, groundbreaking paradigm shift has emerged, highlighting crucial role synaptic communication between neurons tumor cells in reshaping neuronal signaling to favor growth. This review delves into pivotal interplay mechanisms, focusing on excitatory glutamatergic inhibitory GABAergic pathways. Glutamatergic synapses utilize glutamate propagate signals, while employ gamma-aminobutyric acid (GABA) inhibit firing. can be broadly classified ionotropic (NMDAR, AMPAR kainite receptors) metabotropic subtypes. The harmonious orchestration these types is essential normal function, dysregulation implicated neurodegenerative disorders such as Alzheimer's disease epilepsy. Emerging evidence reveals glioma metastatic exploit pathways neurotransmitters enhance proliferation survival. In this review, we will first explore intricate mechanisms underlying signaling. Next, summarize recent advancements understanding how cancer hijack advantage. Finally, propose novel therapeutic strategies aimed at disrupting aberrant neuron-tumor communication, offering potential treatment combating otherwise incurable

Language: Английский

Citations

0
Ketogenic Diet and Neuroinflammation: Implications for Neuroimmunometabolism and Therapeutic Approaches to Refractory Epilepsy DOI Open Access
Daniela Guerreiro, Anabela Almeida, Renata Ramalho

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 3994 - 3994

Published: Nov. 22, 2024

Refractory epilepsy, characterized by seizures that do not respond to standard antiseizure medications, remains a significant clinical challenge. The central role of the immune system on occurrence epileptic disorders has been long studied, but recent perspectives immunometabolism and neuroinflammation are reshaping scientific knowledge. ketogenic diet its variants have considered an important medical nutrition therapy for refractory epilepsy may potential modulation effect system, specifically, metabolism cells. In this comprehensive review, we gathered current evidence-based practice, interventional ongoing trials addressing in epilepsy. We also discussed detail anticonvulsant mechanisms, neuroimmunometabolism, highlighting Th17/Treg homeostasis as one most interesting aspects deserving consideration future trials.

Language: Английский

Citations

2
Relationship between inflammation/immunity and epilepsy: A multi-omics mendelian randomization study integrating GWAS, eQTL, and mQTL data DOI

Jing Mu,

Chang-qing Cao,

Yi-Gu Gong

et al.

Epilepsy & Behavior, Journal Year: 2024, Volume and Issue: 161, P. 110112 - 110112

Published: Oct. 29, 2024

Language: Английский

Citations

1
Ulinastatin Modulates NLRP3 Inflammasome Pathway in PTZ-Induced Epileptic Mice: A Potential Mechanistic Insight DOI Creative Commons
Huan Wang, Yuzhu Ma,

Dongmei Jin

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38050 - e38050

Published: Sept. 19, 2024

Language: Английский

Citations

0
Causal role of peripheral immune cells in epilepsy: A large-scale genetic correlation study DOI
Ting Zhao,

Junshuan Cui,

Shenglian Lan

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113238 - 113238

Published: Sept. 23, 2024

Language: Английский

Citations

0
Research trends of glioma-related epilepsy: A bibliometric analysis from 2004 to 2023 DOI Creative Commons

Ruofei Liang,

Chaosu Hu, Haiyu Li

et al.

Journal of Central Nervous System Disease, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 16, 2024

Glioma-related epilepsy (GRE) is a hotspot in recent years and there remains many urgent unsolved issues. This study aimed to conduct bibliometric analysis on GRE research over the past 2 decades. We collected scientific outputs relating Web of Science Core Collection (WoSCC) from 2004 2023 conducted visual using VOSviewer Microsoft Excel. A total 2697 publications were retrieved with an increasing trend 20 years. The USA ranked first publication number, citation H-index. Institut National de la Sante et Recherche Medicale (Inserm) was institution most publications. In field GRE, core journals Journal Neurosurgery, Epilepsia Neurology. Duffau, Hugues author papers citations, highest Co-occurrence revealed that latest focus awake craniotomy, immunotherapy, cognitive impairment, basic pathogenesis, particular emphasis IDH1 mutation. intended gain deeper understanding current global identify hotspots, as well provide theoretical reference for further studies.

Language: Английский

Citations

0