mRNA vaccines for infectious diseases — advances, challenges and opportunities

Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

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Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 13, 2025

Immunotherapies are effective for cancer treatment but limited in 'cold' tumor microenvironments due to a lack of infiltrating CD8+ T cells, key players the anti-cancer immune response. The onset COVID-19 pandemic sparked widespread use mRNA-formulated vaccines and is well documented that vaccination induces Th1-skewed Here, we evaluated effects an intratumoral injection mRNA vaccine subcutaneous melanoma mouse models. Tumor growth survival studies following single showed significant suppression prolonged established B16F10 tumor-bearing mice. resulted increase cell infiltration into microenvironment, as observed using intravital imaging flow cytometry. Further was achieved additional treatments. Combination administration with checkpoint therapies demonstrated enhanced effects, further delaying improving time This study demonstrates may be used adjuvants immunotherapies.

Language: Английский

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A comparative analysis of five fungal species isolated from high-altitude air samples based on their induction of murine lung eosinophilia along with heated Asian sand dust

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 4, 2025

High-altitude aerosols containing fungi and hyphal debris were collected from the Noto Peninsula, Japan, during Asian sand dust (ASD) events. Five fungal species (Bjerkandera adusta (Bje 07B507), Lecythophora (Lec 13H319), Cladosporium cladosporioides (Cla 16H615), Phialocephala sphaeroides (Phi 15H321), Coniothyrium fuckelii (Con 15H316) isolated. Fungi inactivated using 1% formalin combined with heated-ASD (H-ASD) introduced into respiratory tracts of BALB/c mice. Con 15H316 exhibited most significant exacerbation effect. + H-ASD increased number eosinophils neutrophils in bronchoalveolar lavage fluid along Phi 15H321 enhanced induction interleukin (IL) -5, IL-13, eotaxin compared to other mixed samples. markedly elevated levels IL-6, monocyte chemotactic protein-3, regulated upon activation, normal T cell expressed secreted, lactate dehydrogenase. These changes led pathological alterations, including mucosal proliferation airway epithelium eosinophil infiltration submucosa. The ranking was: 15H316+ > Cla 16H615 Lec 13H319 Bje 07B507+ H-ASD. results suggest that ASD particles can exacerbate allergies human lungs.

Language: Английский

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Plant-made trained immunity-based vaccines: Beyond one approach

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125572 - 125572

Published: April 1, 2025

Language: Английский

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