Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1195 - 1195
Published: March 31, 2025
The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing, with UV radiation being the main cause. Other risk factors are age, sex, skin type and immunosuppression. Human papillomaviruses (HPVs) associated benign malignant tumours. In contrast to anogenital oropharyngeal carcinomas, which caused by alpha papillomaviruses, HPV types cSCC belong beta-HPV genus. These viruses infect epithelium widespread in samples from healthy people. It assumed that amplifies DNA damage disrupts repair mechanisms cells, without remaining permanently detectable tumour tissue, so-called hit-and-run theory. status tumours appears have a positive influence on prognosis response therapy due increased immune infiltration, particular tissue-resident memory T cells activation effector cells. This favours responses immunotherapies such as PD-1/PD-L1 inhibitors, whereas immunosuppression may promote pro-carcinogenic effect. conclusion, role beta development be closely host. Depending status, can play either protective or tumour-promoting role, view increasing cancer worldwide, enhancing against virus-infected keratinocytes, e.g., through vaccination, could represent promising approach for prevention carcinomas.
Language: Английский