Creating a plasma coordination center to support COVID-19 outpatient trials across a national network of hospital blood banks DOI Creative Commons
Anusha Yarava,

Christi E. Marshall,

Dietmar Reichert

et al.

Journal of Clinical and Translational Science, Journal Year: 2024, Volume and Issue: 8(1)

Published: Jan. 1, 2024

In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, support transfusion for outpatient randomized controlled trials. The center design was based on an investigational drug services model and Food Drug Administration-compliant database manage blood product inventory trial safety. A core team adapted cloud-based platform randomize patient assignments track distribution of control high-titer convalescent different groups from 29 donor collection centers directly banks serving 26 sites. We performed 1,351 transfusions in 16 months. transparency digital at each site critical facilitate qualification, randomization, overnight shipments group-compatible into participants. While challenges were heightened with plasma, system, flexible approach staff across bank network enabled decentralized procurement products maintain thresholds overcome local supply chain restraints rapid creation is infrequent academic setting. Distributing more than 3,100 units charged managing U.S. manner posed operational regulatory while providing opportunities contribute research global importance. This program can serve as template subsequent public health emergencies.

Language: Английский

Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma DOI Creative Commons
Quigly Dragotakes, Patrick W. Johnson,

Matthew R. Buras

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(41)

Published: Oct. 1, 2024

In the Spring of 2020, United States America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP during first year pandemic. this study, we estimated number actual inpatient lives saved by treatment in based on weekly use, national mortality data, and reduction data from meta-analyses randomized controlled trials real-world data. We also estimate potential if had been for 100% or used 15 75% outpatients. Depending assumptions modeled stratified analyses, that between 16,476 66,296 lives. The ideal use might have as many 234,869 prevented 1,136,133 hospitalizations. deployment was a successful strategy ameliorating impact pandemic USA. This experience has important implications future infectious disease emergencies.

Language: Английский

Citations

6
Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial DOI
Visa Nurmi, Richard Mayne,

Chanice Knight

et al.

Journal of Infection, Journal Year: 2025, Volume and Issue: unknown, P. 106412 - 106412

Published: Jan. 1, 2025

Language: Английский

Citations

0
Creating a plasma coordination center to support COVID-19 outpatient trials across a national network of hospital blood banks DOI Creative Commons
Anusha Yarava,

Christi E. Marshall,

Dietmar Reichert

et al.

Journal of Clinical and Translational Science, Journal Year: 2024, Volume and Issue: 8(1)

Published: Jan. 1, 2024

In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, support transfusion for outpatient randomized controlled trials. The center design was based on an investigational drug services model and Food Drug Administration-compliant database manage blood product inventory trial safety. A core team adapted cloud-based platform randomize patient assignments track distribution of control high-titer convalescent different groups from 29 donor collection centers directly banks serving 26 sites. We performed 1,351 transfusions in 16 months. transparency digital at each site critical facilitate qualification, randomization, overnight shipments group-compatible into participants. While challenges were heightened with plasma, system, flexible approach staff across bank network enabled decentralized procurement products maintain thresholds overcome local supply chain restraints rapid creation is infrequent academic setting. Distributing more than 3,100 units charged managing U.S. manner posed operational regulatory while providing opportunities contribute research global importance. This program can serve as template subsequent public health emergencies.

Language: Английский

Citations

0