Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy DOI Creative Commons
Enrico Apa,

Nicole Carrie Tegmeyer,

Concetta D’Adamo

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1237 - 1237

Published: Sept. 27, 2024

Studies about the effects of SARS-CoV-2 on pregnant women and children born to positive are controversial with regard possible inner ear-related damage but most them do not detect involvement this virus in auditory function. However, only a few studies long-term language development currently available because recent onset pandemic. The aim study was investigate impact infection perceptual expressive abilities emerging communication young children. To purpose, MacArthur-Bates Communicative Development Inventory-Words Gestures form (CDI-WG), administered parents. In total, 115 whose mother infected by during pregnancy were enrolled evaluated at Audiology Service Modena University Hospital. All underwent Otoacoustic Emissions (OAE) birth: 114/115 had "pass" result bilaterally, while 1 case unilateral "refer" result. Overall, 110/115 newborns (95.65%) audiological evaluation between 10-18 months age. 5/110 patients (3.6%), Pure Tone Average (PTA) equal 35 dB; one hearing threshold around 50 dB due bilateral effusive otitis media. A notable finding percentage tubal dysfunction both evaluations, within 2 age 12 Most revealed normal hearing. CDI-WG completed 56/115 families. rate below fifth percentile 8.9% for sentences understood, 12.5% words 5.4% produced. Concerning CDI-Gestures, (3.6%) percentile. structured follow-up association skills appears fundamental, particularly years maximum neuroplasticity. Long-term still necessary evaluate consequences

Language: Английский

Animal Models for Long COVID: Current Advances, Limitations, and Future Directions DOI
Yu Zhang, Huan Chen, Yumeng Li

et al.

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(2)

Published: Feb. 1, 2025

ABSTRACT Long COVID (LC) represents a chronic, systemic, and often disabling condition that poses significant ongoing threat to public health. Foundational scientific studies are needed unravel the underlying mechanisms, with ultimate goal of developing effective preventative therapeutic strategies. Therefore, there is an urgent demand for animal models can accurately replicate clinical features LC. This review integrates epidemiological data summarize pathological changes in extrapulmonary systems involved Additionally, it critically examines capacity existing models, including nonhuman primates, genetically modified mice, Syrian hamsters, exhibit enduring postinfection symptoms align human manifestations, identifies key areas requiring further development. The objective offer insights will aid development next‐generation thereby accelerating our understanding how acute respiratory viral infections transition into chronic conditions, ensuring preparedness future pandemics.

Language: Английский

Citations

0
Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment DOI Creative Commons
Abigail J. Dutton,

Evelyn M. Turnbaugh,

Chaya Patel

et al.

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(2), P. e1012935 - e1012935

Published: Feb. 7, 2025

Neonatal herpes simplex virus (nHSV) is a devastating infection impacting approximately 14,000 newborns globally each year. nHSV associated with high neurologic morbidity and mortality, making early intervention critical. Clinical outcomes of symptomatic infections are well-studied, but little known about the frequency of, or following, subclinical asymptomatic nHSV. Given ubiquitous nature HSV shedding in adults, underreported could contribute to long-term neurological damage. To assess potential infection, we developed low-dose (100 PFU) intranasal model neonatal wild-type C57BL/6 mice. At this dose, DNA was detected brain by quantitative PCR (qPCR) not acute clinical signs infection. However, months after inoculation low dose HSV, observed impaired mouse performance on range cognitive memory tests. Memory impairment induced either HSV-1 HSV-2 viruses, indicating that strain-specific. Maternal immunization reduced neonate central nervous system (CNS) viral burden prevented offspring from developing sequelae following Altogether, these results support idea may lead decline adulthood maternal vaccination an effective strategy for reducing infected offspring. These findings have profound implications understanding modeling etiology human neurodegenerative disorders such as Alzheimer's Disease.

Language: Английский

Citations

0
The Role of ACE2 in Neurological Disorders: From Underlying Mechanisms to the Neurological Impact of COVID-19 DOI Open Access
Jingwen Li, Xiangrui Kong, Tingting Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9960 - 9960

Published: Sept. 15, 2024

Angiotensin-converting enzyme 2 (ACE2) has become a hot topic in neuroscience research recent years, especially the context of global COVID-19 pandemic, where its role neurological diseases received widespread attention. ACE2, as multifunctional metalloprotease, not only plays critical cardiovascular system but also an important protection, development, and inflammation regulation nervous system. The pandemic further highlights importance ACE2 SARS-CoV-2 enters host cells by binding to which may directly or indirectly affect system, leading range symptoms. This review aims explore function well potential impact therapeutic various diseases, providing new perspective for treatment disorders.

Language: Английский

Citations

2
KANET evaluation in patients with SARS-CoV-2 DOI
Zacharias Fasoulakis,

Asim Kurjak,

Ioakeim Sapantzoglou

et al.

Journal of Perinatal Medicine, Journal Year: 2024, Volume and Issue: 52(8), P. 811 - 816

Published: Aug. 29, 2024

Abstract Objectives To determine a possible correlation between SARS-CoV-2 infection during pregnancy and altered fetal behavior. Methods Kurjak’s antenatal neurodevelopmental test (KANET) was applied from 28 to 40 weeks in 38 gestations (group A) diagnosed with COVID-19 the first week 43 non-COVID pregnant women B). Results No statistically significant differences considering maternal age (33±3.9 years for group A vs. 31±4.1 B) gestational (33±1.6 compared 33±2.1 were observed. KANET scores not different two groups. Conclusions Fetal behavior are third trimester of pregnancy.

Language: Английский

Citations

0
Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy DOI Creative Commons
Enrico Apa,

Nicole Carrie Tegmeyer,

Concetta D’Adamo

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1237 - 1237

Published: Sept. 27, 2024

Studies about the effects of SARS-CoV-2 on pregnant women and children born to positive are controversial with regard possible inner ear-related damage but most them do not detect involvement this virus in auditory function. However, only a few studies long-term language development currently available because recent onset pandemic. The aim study was investigate impact infection perceptual expressive abilities emerging communication young children. To purpose, MacArthur-Bates Communicative Development Inventory-Words Gestures form (CDI-WG), administered parents. In total, 115 whose mother infected by during pregnancy were enrolled evaluated at Audiology Service Modena University Hospital. All underwent Otoacoustic Emissions (OAE) birth: 114/115 had "pass" result bilaterally, while 1 case unilateral "refer" result. Overall, 110/115 newborns (95.65%) audiological evaluation between 10-18 months age. 5/110 patients (3.6%), Pure Tone Average (PTA) equal 35 dB; one hearing threshold around 50 dB due bilateral effusive otitis media. A notable finding percentage tubal dysfunction both evaluations, within 2 age 12 Most revealed normal hearing. CDI-WG completed 56/115 families. rate below fifth percentile 8.9% for sentences understood, 12.5% words 5.4% produced. Concerning CDI-Gestures, (3.6%) percentile. structured follow-up association skills appears fundamental, particularly years maximum neuroplasticity. Long-term still necessary evaluate consequences

Language: Английский

Citations

0