Sympathetic nociceptive afferent signaling drives the chronic structural and functional autonomic remodeling after myocardial infarction

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

After myocardial infarction (MI), pathological autonomic remodeling, including vagal dysfunction and sympathoexcitation, occurs predisposes to ventricular arrhythmias (VT/VF). The underlying factors that drive this the observed neuroinflammation glial activation, remain unknown. We hypothesized sympathetic nociceptive afferents underlie remodeling post-MI. Epidural resiniferatoxin (RTX, ablate cardiac afferent neurons) vs. saline was administered in pigs prior MI electrophysiological effects assessed four six weeks post-infarction. Acute of ablation after chronic were also a separate group animals. Baroreflex sensitivity tone, as measured by parasympathetic neuronal activity responses, improved infarcted animals which received epidural RTX MI. These demonstrated reduced spinal cord inflammation downregulation circulating stress inflammatory pathways, stabilization parameters, with VT/VF-inducibility. acutely restored function decreased VT/VF. data suggest directly contribute VT/VF susceptibility MI-induced oxidative stress, inflammation, function, providing novel insights into causal role these driving sympathovagal imbalance

Language: Английский

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Sympathetic nociceptive afferent signaling drives the chronic structural and functional autonomic remodeling after myocardial infarction

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT After myocardial infarction (MI), pathological autonomic remodeling, including vagal dysfunction and sympathoexcitation, occurs predisposes to ventricular arrhythmias (VT/VF). The underlying factors that drive this the observed neuroinflammation glial activation, remain unknown. We hypothesized sympathetic nociceptive afferents underlie remodeling post-MI. Epidural resiniferatoxin (RTX, ablate cardiac afferent neurons) vs. saline was administered in pigs prior MI electrophysiological effects assessed four six weeks post-infarction. Acute of ablation after chronic were also a separate group animals. Baroreflex sensitivity tone, as measured by parasympathetic neuronal activity responses, improved infarcted animals which received epidural RTX MI. These demonstrated reduced spinal cord inflammation downregulation circulating stress inflammatory pathways, stabilization parameters, with VT/VF-inducibility. acutely restored function decreased VT/VF. data suggest directly contribute VT/VF susceptibility MI-induced oxidative stress, inflammation, function, providing novel insights into causal role these driving sympathovagal imbalance

Language: Английский

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A novel lactylation-related gene signature for diagnostic and therapeutic insights in acute myocardial infarction

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 28, 2025

Language: Английский

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