Circulating microRNAs and physical activity: Impact in diabetes
Clinica Chimica Acta,
Journal Year:
2025,
Volume and Issue:
unknown, P. 120178 - 120178
Published: Feb. 1, 2025
Language: Английский
Skeletal muscle growth to combat diabetes and obesity: the potential role of muscle‐secreted factors
Obesity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Abstract
As
the
prevalence
of
obesity
and
metabolic
disease
continues
to
climb,
need
for
effective
therapeutic
interventions
remains
high.
The
growth
skeletal
muscle
(SkM)
greatly
influences
systemic
metabolism
across
whole
body,
making
this
tissue
an
important
target
combat
rise
dysfunction.
Transgenic
rodent
models
targeted
SkM
exhibit
profound
improvements
in
various
remote
tissues,
including
adipose
liver.
It
is
currently
unclear
how
selective
stimulation
alters
distant
tissues;
however,
evidence
suggests
that
muscle‐secreted
factors
may
be
involved.
Here,
we
aim
provide
basic
biomedical
researchers
with
a
summary
current
knowledge
regarding
regulated
by
anabolic
pathways
proteins
SkM,
as
well
their
effects,
implicate
them
whole‐body
effects
growth.
In
review,
also
identify
several
gaps
field,
future
directions
investigation,
implications
such
resistance
exercise
pharmacology.
image
Language: Английский
A primer on global molecular responses to exercise in skeletal muscle: Omics in focus
Journal of sport and health science/Journal of Sport and Health Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101029 - 101029
Published: Feb. 1, 2025
Advances
in
skeletal
muscle
omics
has
expanded
our
understanding
of
exercise-induced
adaptations
at
the
molecular
level.
Over
past
2
decades,
transcriptome
studies
have
detailed
acute
and
chronic
responses
to
resistance,
endurance,
concurrent
exercise,
focusing
on
variables
such
as
training
status,
nutrition,
age,
sex,
metabolic
health
profile.
Multi-omics
approaches,
integration
transcriptomic
epigenetic
data,
along
with
emerging
ribosomal
RNA
sequencing
advancements,
further
provided
insights
into
how
adapts
exercise
across
lifespan.
Downstream
transcriptome,
proteomic
phosphoproteomic
identified
novel
regulators
adaptations,
while
single-cell/nucleus
spatial
technologies
promise
evolve
cellular
specialization
communication
around
cells.
This
narrative
review
highlights
(a)
historical
foundations
muscle,
(b)
current
research
3
layers
cascade
(DNA,
RNA,
protein),
(c)
applications
single-cell
study
adaptation
exercise.
Further
elaboration
muscle's
global
footprint
using
multi-omics
methods
will
help
researchers
practitioners
develop
more
effective
targeted
approaches
improve
well
athletic
performance.
Language: Английский
MiR-1 alleviates chronic heart failure through HCN2/HCN4 axis in vitro
Tissue and Cell,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102921 - 102921
Published: April 1, 2025
Language: Английский
Adipose Tissue as a Major Launch Spot for Circulating Extracellular Vesicle-Carried MicroRNAs Coordinating Tissue and Systemic Metabolism
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13488 - 13488
Published: Dec. 17, 2024
Circulating
microRNAs
(miRNAs),
especially
transported
by
extracellular
vesicles
(EVs),
have
recently
emerged
as
major
new
participants
in
interorgan
communication,
playing
an
important
role
the
metabolic
coordination
of
our
tissues.
Among
these,
adipose
tissue
displays
extraordinary
ability
to
secrete
a
vast
list
EV-carried
miRNAs
into
circulation,
representing
hormone-like
factors.
Despite
limitations
current
methodologies
for
unequivocal
identification
origin
and
destination
vivo,
recent
investigations
clearly
support
regulatory
adipose-derived
circulating
shaping
metabolism
function
other
tissues
including
liver,
muscle,
endocrine
pancreas,
cardiovascular
system,
gastrointestinal
tract,
brain.
Here,
we
review
most
findings
regarding
EVs
(AdEVs)
targeting
organs
implications
this
dialog
physiology
pathology.
We
also
here
potential
future
diagnostic
therapeutic
applications
AdEV-carried
miRNAs.
Language: Английский