The role of epigenetics in the development of childhood asthma DOI Creative Commons
Cancan Qi, Cheng‐Jian Xu, Gerard H. Koppelman

et al.

Expert Review of Clinical Immunology, Journal Year: 2019, Volume and Issue: 15(12), P. 1287 - 1302

Published: Nov. 1, 2019

Introduction: The development of childhood asthma is caused by a combination genetic factors and environmental exposures. Epigenetics describes mechanisms (heritable) regulation gene expression that occur without changes in DNA sequence. strongly related to aging, cell-type specific, includes methylation, noncoding RNAs, histone modifications.Areas covered: This review summarizes recent epigenetic studies humans, which mostly involve methylation published the five years. Environmental exposures, particular cigarette smoking, have significant impact on changes, but few these signals are also associated with asthma. Several asthma-associated variants relate methylation. Epigenetic can be better understood studying their correlation expression, revealed higher presence activation blood eosinophils Strong associations nasal signatures atopic were identified, replicable across different populations.Expert commentary: markers been asthma, might serve as biomarker causal longitudinal relationships between epigenetics disease, exposures need further investigated. Efforts should made understand cell-type-specific

Language: Английский

PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling DOI
Peipei Cheng, Fan Yu, Shuai-Jun Chen

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 347, P. 123674 - 123674

Published: March 6, 2024

Language: Английский

Citations

8
Energy poverty and respiratory health in Sub-Saharan Africa: Effects and transmission channels DOI
Thierry Messie Pondie,

Fon Dorothy Engwali,

Bruno Emmanuel Ongo Nkoa

et al.

Energy, Journal Year: 2024, Volume and Issue: 297, P. 131158 - 131158

Published: April 11, 2024

Language: Английский

Citations

8
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis DOI

Surui Ai,

Le Liu, Yuan Xue

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(2), P. 149 - 163

Published: April 19, 2024

Language: Английский

Citations

7
Allergic symptoms in association with naturalness, greenness, and greyness: A cross-sectional study in schoolchildren in the Alps DOI
Angel M. Dzhambov, Peter Lercher, Johannes Rüdisser

et al.

Environmental Research, Journal Year: 2020, Volume and Issue: 198, P. 110456 - 110456

Published: Nov. 11, 2020

Language: Английский

Citations

48
The role of epigenetics in the development of childhood asthma DOI Creative Commons
Cancan Qi, Cheng‐Jian Xu, Gerard H. Koppelman

et al.

Expert Review of Clinical Immunology, Journal Year: 2019, Volume and Issue: 15(12), P. 1287 - 1302

Published: Nov. 1, 2019

Introduction: The development of childhood asthma is caused by a combination genetic factors and environmental exposures. Epigenetics describes mechanisms (heritable) regulation gene expression that occur without changes in DNA sequence. strongly related to aging, cell-type specific, includes methylation, noncoding RNAs, histone modifications.Areas covered: This review summarizes recent epigenetic studies humans, which mostly involve methylation published the five years. Environmental exposures, particular cigarette smoking, have significant impact on changes, but few these signals are also associated with asthma. Several asthma-associated variants relate methylation. Epigenetic can be better understood studying their correlation expression, revealed higher presence activation blood eosinophils Strong associations nasal signatures atopic were identified, replicable across different populations.Expert commentary: markers been asthma, might serve as biomarker causal longitudinal relationships between epigenetics disease, exposures need further investigated. Efforts should made understand cell-type-specific

Language: Английский

Citations

45