Circadian gating: concepts, processes, and opportunities DOI
Pirita Paajanen, Jacqueline M. Kimmey, Antony N. Dodd

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

Circadian clocks provide a biological measure of time that coordinates metabolism, physiology and behaviour with 24 h cycles in the environment. systems have variety characteristic properties, such as entrainment to environmental cues, self-sustaining rhythm about temperature compensation circadian rhythm. In this perspective, we discuss process gating, which refers restriction event particular times day by clock. We introduce principles processes associated gating organisms, including some mechanisms. highlight socioeconomic opportunities presented investigation using selected examples from medicine agricultural crop production illustrate its importance. This article is part Theo Murphy meeting issue ‘Circadian rhythms infection immunity’.

Language: Английский

Trained immunity-related vaccines: innate immune memory and heterologous protection against infections DOI

Athanasios Ziogas,

Mihai G. Netea

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(6), P. 497 - 512

Published: April 21, 2022

Language: Английский

Citations

59
Adaptive immunity, chronic inflammation and the clock DOI Creative Commons
Kathryn J. Gray, Julie E. Gibbs

Seminars in Immunopathology, Journal Year: 2022, Volume and Issue: 44(2), P. 209 - 224

Published: March 1, 2022

Abstract The adaptive arm of the immune system facilitates recognition specific foreign pathogens and, via action T and B lymphocytes, induces a fine-tuned response to target pathogen develop immunological memory. functionality exhibits daily 24-h variation both in homeostatic processes (such as lymphocyte trafficking development subsets) responses challenge. Here, we discuss how circadian clock exerts influence over function system, considering roles cell intrinsic clockwork machinery extrinsic rhythmic signals. Inappropriate or misguided actions can lead autoimmune diseases such rheumatoid arthritis, ulcerative colitis multiple sclerosis. Growing evidence indicates that disturbance has negative impact on progression these chronic inflammatory examine current understanding clock-immune interactions setting conditions. A greater appreciation control immunity will facilitate further mechanisms driving disease states drive improvements diagnosis treatment diseases.

Language: Английский

Citations

47
Effect of gender, age and vaccine on reactogenicity and incapacity to work after COVID-19 vaccination: a survey among health care workers DOI Creative Commons
Irit Nachtigall, Marzia Bonsignore, Sven Hohenstein

et al.

BMC Infectious Diseases, Journal Year: 2022, Volume and Issue: 22(1)

Published: March 26, 2022

Abstract Background The aim of our study was to assess the impact gender and age on reactogenicity three COVID-19 vaccine products: Biontech/Pfizer (BNT162b2), Moderna (mRNA-1273) AstraZeneca (ChAdOx). Additional analyses focused reduction in working capacity after vaccination influence time day when vaccines were administered. Methods We conducted a survey vaccinations eventual reactions among 73,000 employees 89 hospitals Helios Group. On May 19th, 2021 all received an email, inviting who at least 1 dose participate using attached link. Additionally, invitation posted group’s intranet page. Participation voluntary non-traceable. closed June 21st, 2021. Results 8375 participants reported 16,727 vaccinations. Reactogenicity 74.6% After 23.0% work affected. ChAdOx induced impairing mainly prime (70.5%), while mRNA-1273 led more pronounced second (71.6%). Heterologous prime-booster with followed by either or BNT162b2 associated highest risk for impairment (81.4%). Multivariable identified factors older age, male BNT162b as independently lower odds ratio both, incapacity work. In comparison schedules, heterologous combination + homologue lowest ratios. had no significant influence. Conclusions Around 75% nearly 25% them one days loss. Major female gender, younger administration other than BNT162b2. When vaccinating large part workforce against COVID-19, especially professions higher proportion young women such health care, employers must be prepared noticeable amount absenteeism. Assuming effectiveness equivalent across combinations, minimize reactogenicity, should receive homologous immunisation Trial registration: approved Ethic Committee Aerztekammer Berlin 27th, (Eth-37/21) registered German Clinical Trials Register (DRKS 00025745). supported research grant HCRI-ID 2021-0272.

Language: Английский

Citations

45
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing DOI Creative Commons

Mariana P. Cervantes‐Silva,

Richard G. Carroll, Mieszko M. Wilk

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 5, 2022

Abstract Dendritic cells play a key role in processing and presenting antigens to naïve T prime adaptive immunity. Circadian rhythms are known regulate many aspects of immunity; however, the circadian dendritic cell function is still unclear. Here, we show greater responses when mice immunised middle their rest versus active phase. We find rhythm antigen that correlates with both mitochondrial morphology metabolism, dependent on molecular clock gene, Bmal1 . Using Mdivi-1, compound promotes fusion, able rescue deficit mechanistically link processing. Furthermore, changes Ca 2+ central regulation Our results indicate rhythmic calcium, which associated morphology,

Language: Английский

Citations

45
Influence of circadian clocks on adaptive immunity and vaccination responses DOI Creative Commons
Louise M. Ince, Coline Barnoud, Lydia K. Lutes

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 30, 2023

Abstract The adaptive immune response is under circadian control, yet, why reactions continue to exhibit changes over long periods of time unknown. Using a combination experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin draining lymph node in time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression TNF enhances BMAL1-controlled ICAM-1 high endothelial venules, resulting lymphocyte infiltration expansion. Lymph cellularity continues be different weeks after initial challenge, governs vaccinations directed against Hepatitis A virus as well SARS-CoV-2. In this work, present mechanistic understanding time-of-day dependent development maintenance response, providing strategy using optimize vaccination regimes.

Language: Английский

Citations

41
Neural control of immune cell trafficking DOI Creative Commons
Scott N. Mueller

The Journal of Experimental Medicine, Journal Year: 2022, Volume and Issue: 219(3)

Published: Feb. 23, 2022

Leukocyte trafficking between blood and tissues is an essential function of the immune system that facilitates humoral cellular responses. Within tissues, leukocytes perform surveillance effector functions via cell motility migration toward sites tissue damage, infection, or inflammation. Neurotransmitters are produced by nervous influence leukocyte around body interstitial cells in tissues. Neural regulation dynamics influenced circadian rhythms altered stress disease. This review examines current knowledge neuro–immune interactions regulate consequences for protective immunity against infections cancer.

Language: Английский

Citations

39
Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections DOI Creative Commons
Jelmer H. van Puffelen, Boris Novakovic,

Liesbeth van Emst

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2023, Volume and Issue: 11(1), P. e005518 - e005518

Published: Jan. 1, 2023

BCG is recommended as intravesical immunotherapy to reduce the risk of tumor recurrence in patients with non-muscle invasive bladder cancer (NMIBC). Currently, it unknown whether application induces trained immunity.The aim this research was determine immunity NMIBC patients. We conducted a prospective observational cohort study 17 scheduled for therapy and measured parameters at 9 time points before during 1-year maintenance regimen. Ex vivo cytokine production by peripheral blood mononuclear cells, epigenetic modifications, changes monocyte transcriptome were measured. The frequency respiratory infections investigated two larger cohorts BCG-treated non-BCG treated surrogate measurement immunity. Gene-based association analysis genetic variants candidate genes their recurrence-free survival progression-free after performed investigate hypothesized link between clinical response.We found that does induce based on an increased TNF IL-1β heterologous ex stimulation circulating monocytes 6-12 weeks treatment; 37% decreased (OR 0.63 (95% CI 0.40 1.01)) versus non-BCG-treated An epigenomics approach combining chromatin immuno precipitation-sequencing RNA-sequencing vitro experiments identified enhanced inflammasome activity individuals. Finally, germline variation affect associated progression NMIBC.We conclude may account protective effects against infections. data our gene-based suggest oncological outcome exist. Future studies should further how affects antitumor immune responses

Language: Английский

Citations

31
Clinical outcomes by infusion timing of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer DOI Creative Commons
Adrien Rousseau, Marco Tagliamento, Édouard Auclin

et al.

European Journal of Cancer, Journal Year: 2023, Volume and Issue: 182, P. 107 - 114

Published: Jan. 13, 2023

Language: Английский

Citations

28
A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity DOI Creative Commons
Wenchao Li, Simone J.C.F.M. Moorlag, Valerie A. C. M. Koeken

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(5), P. 112487 - 112487

Published: May 1, 2023

Bacillus Calmette-Guérin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results more effective response innate immune cells upon stimulation with heterologous stimuli. Here, we investigate heterogeneity TI induction by single-cell RNA sequencing collected from 156 samples. We observe that both monocytes CD8+ T show transcriptional responses to lipopolysaccharide, an active crosstalk between these two cell types. Furthermore, interferon-γ pathway crucial BCG-induced TI, it upregulated functional high responders. Data-driven analyses experiments reveal STAT1 be one important transcription factors shared all identified monocyte subpopulations. Finally, report role type I interferon-related neutrophil-related programs patients sepsis. These findings provide comprehensive insights into importance during humans.

Language: Английский

Citations

26
Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients DOI Creative Commons
Guy Hazan, Or Duek, Hillel Alapi

et al.

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(11)

Published: April 13, 2023

BACKGROUND. Circadian rhythms are evident in basic immune processes, but it is unclear if exist clinical endpoints like vaccine protection. Here, we examined associations between COVID-19 vaccination timing and effectiveness.

Language: Английский

Citations

25