Cited by p75NTR mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mTOR pathway

Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders DOI

Egon A. Ozer, Abdurrahman Keskin,

Yusuf Huseyin Berrak

et al.

Discover Mental Health, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 22, 2025

Viral infections may disrupt the structural and functional integrity of nervous system, leading to acute conditions such as encephalitis, neuropsychiatric mood disorders, schizophrenia, neurodegenerative diseases. Investigating viral interactions human proteins reveal mechanisms underlying these effects offer insights for therapeutic interventions. This study explores molecular virus that be related disorders. Herpes Simplex Virus-1 (HSV-1), Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), Influenza A (IAV) (H1N1, H5N1), Human Immunodeficiency (HIV1&2) were selected key viruses. Protein structures each accessed from Data Bank analyzed using HMI-Pred web server detect interface mimicry between proteins. The PANTHER classification system was used categorize viral-human protein based on function cellular localization. Energetically favorable identified HSV-1 (467), CMV (514), EBV (495), H1N1 (3331), H5N1 (3533), HIV 1&2 (62425). Besides immune apoptosis-related pathways, including those associated with Parkinson's Huntington's diseases, frequently interacted. total 38 proteins, calmodulin 2, Ras-related botulinum toxin substrate 1 (Rac1), PDGF-β, vimentin, found interact all six indicates a substantial number energetically underscoring complexity breadth strategies hijack host mechanisms. Further in vivo vitro validation is required understand implications interactions.

Language: Английский

Citations

Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice DOI

Zi-Long Yi,

Jin-Nan Lu, Jinjin Zhu

et al.

Molecular Pain, Journal Year: 2024, Volume and Issue: 20

Published: Jan. 1, 2024

Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disease characterized by chronic visceral pain with complex etiology and challenging treatment. Although accumulating evidence supports the involvement of central nervous system sensitization in development pain, precise molecular mechanisms remain incompletely understood. In this study, we highlight critical regulatory role lysine-specific demethylase 6B (KDM6B) anterior cingulate cortex (ACC) pain. To simulate clinical IBS conditions, utilized neonatal maternal deprivation (NMD) mouse model. Our results demonstrated that NMD induced anxiety-like behaviors mice. Notably, protein expression level KDM6B significantly increased ACC mice, leading to reduction H32K7me3. Immunofluorescence staining revealed primarily co-localizes neurons ACC, minimal presence microglia astrocytes. Injecting GSK-J4 (a KDM6B-specific inhibitor) into resulted significant alleviation behaviors, as well remarkable NR2B level. ChIP assay further indicated regulates influencing demethylation H3K27me3. summary, our findings underscore regulating These insights provide basis for understanding pathways involved may pave way targeted therapeutic interventions.

Language: Английский

Citations

Shared effects of electroconvulsive shocks and ketamine on neuroplasticity: A systematic review of animal models of depression DOI

Jesca E. De Jager,

Rutger Boesjes,

Gijs H.J. Roelandt

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105796 - 105796

Published: July 7, 2024

Language: Английский

Citations

The therapeutic potential of traditional Chinese medicine in depression: focused on the modulation of neuroplasticity DOI

Shimeng Lv,

Ni Yang,

Yitong Lu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 26, 2024

Depression, a mood disorder characterized by persistent low and lack of enjoyment, is considered the leading cause non-fatal health losses worldwide. Neuroplasticity refers to brain’s ability adapt external or internal stimuli, resulting in functional structural changes. This process plays crucial role development depression. Traditional Chinese Medicine (TCM) shows significant potential as complementary alternative therapy for neurological diseases, including However, there has been no systematic summary neuroplasticity pathological depression TCM Interventions currently. review systematically summarized recent literature on changes analyzed regulatory mechanisms active metabolites formulas antidepressant treatment. Additionally, this discussed limitations current research application prospects regulating research.

Language: Английский

Citations

p75NTR mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mTOR pathway DOI

Yu-Yuan Peng,

Can Tang,

Haiyan Wang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123175 - 123175

Published: Oct. 1, 2024

Language: Английский

Citations