Immunological characteristics in elderly COVID-19 patients: a post-COVID era analysis DOI Creative Commons
Yunhui Li,

Yuan Chen,

Jing Liang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 29, 2024

Advanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. In the post-pandemic era, with containment measures lifted, elderly remain particularly susceptible, highlighting need intensified focus on immune health management.

Language: Английский

The C5AR1/TNFSF13B axis alleviates osteoarthritis by activating the PI3K/Akt/GSK3β/Nrf2/HO-1 pathway to inhibit ferroptosis DOI

Min Lv,

Yuanzhen Cai,

Weikun Hou

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 441(2), P. 114195 - 114195

Published: Aug. 1, 2024

Language: Английский

Citations

2
Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury DOI Creative Commons
Yi Liu, Rong Wang, Congkuan Song

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 7, 2023

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated death, occurring during or within 6 hours after transfusion. Reports indicate that TRALI can be categorized as having lacking respiratory distress syndrome (ARDS) risk factors. There are two types in terms its pathogenesis: antibody-mediated and non-antibody-mediated. The key initiation steps involve priming activation neutrophils, with neutrophil extracellular traps (NETs) being established effector molecules formed by activated neutrophils response to various stimuli. These NETs contribute production release reactive oxygen species (ROS) participate destruction pulmonary vascular endothelial cells. significant role well recognized, offering a potential pathway for treatment. Moreover, platelets, macrophages, cells, complements have been identified promoters NET formation. Concurrently, studies demonstrated storage platelets concentrated red blood cells (RBC) induce through bioactive lipids. In this article, recent clinical pre-clinical on pathophysiology pathogenesis reviewed further illuminate mechanism which TRALI. This review aims propose new therapeutic strategies TRALI, hope effectively improving poor prognosis.

Language: Английский

Citations

4
Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction DOI
Manling Xie, Zhen He,

Bing Bin

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111874 - 111874

Published: March 16, 2024

Language: Английский

Citations

1
Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury DOI Creative Commons
Hrishikesh S. Kulkarni

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(11)

Published: June 2, 2024

Although antibody-mediated lung damage is a major factor in transfusion-related acute injury (ALI), autoimmune disease (for example, coatomer subunit α [COPA] syndrome), and primary graft dysfunction following transplantation, the mechanism by which antigen-antibody complexes activate complement to induce remains unclear. In this issue of JCI, Cleary colleagues utilized several approaches demonstrate that IgG forms hexamers with MHC class I alloantibodies. This hexamerization served as key pathophysiological alloimmune models was mediated through classical pathway activation. Additionally, authors provided avenues for exploring therapeutics currently hard-to-treat clinical entity has etiologies but potentially focused mechanism.

Language: Английский

Citations

1
Phytoconstituents as modulator of inflammatory pathways for COVID‐19: A comprehensive review and recommendations DOI

Pragati Gupta,

Kamal Dev, Gurjot Kaur

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract SARS‐CoV‐2 infection causes disruptions in inflammatory pathways, which fundamentally contribute to COVID‐19 pathophysiology. The present review critically evaluates the gaps scientific literature and presents current status regarding signaling pathways COVID‐19. We propose that phytoconstituents can be used treat associated inflammation, several already formulated traditional medications. For this purpose, extensive analysis was conducted PubMed database collect relevant vitro, vivo, human patient studies where inflammation were shown upregulated Parallelly, screened for with known cellular mechanisms implicated or inflammation. Studies insufficient evidence on autophagy mitophagy considered out of scope excluded from study. final visualized figures evaluated accuracy. Our findings demonstrate frequent participation NF‐κB, a transcription factor, linked Moreover, MAPK pathway is also producing molecules. Furthermore, it analyzed flavonoid phenolic backbones could inhibit either TLR4 receptor its consecutive molecules, thereby, decreasing NF‐κB activity suppressing cytokine production. Although, allopathy has treated early phase COVID‐19, anti‐inflammatory existing ayurvedic formulations may act provide an additional treatment strategy. Therefore, we recommend usage flavonoids similar viral ailments.

Language: Английский

Citations

0
Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm DOI Creative Commons
Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Introduction Complement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction level circulating intact complement components can be mentioned, and this change has also been detected envenomation by multiple Africanized honeybee (Apis mellifera) stings. Although animals elicits diverse life-threatening reactions, capacity bee venom (AmV) to activate human system remains elusive. Methods By coupling immunochemical functional approaches, it was that AmV strongly consumes alternative pathway (AP) normal serum (NHS). Additionally, interfered with classical (CP) lectin pathways (LP) activities. In parallel, high increase Ba fragment levels detected, suggesting changes AP activity were due its activation. Furthermore, an C1s-C1INH complex decrease physiological MASP1-C1INH suggested CP LP activated presence AmV. Strikingly, NHS exposed increasing concentrations varying from 5 1000 µg/mL presented generation C3a, C4a C5a anaphylatoxins, sC5b-9 complexes assembly, thus reinforcing triggers Conclusion These results show is strong activator. This presents mixed profile, predominance suggests play important roles honeybee, as they could induce events patients may dictate patient clinical prognosis.

Language: Английский

Citations

0
Immunological characteristics in elderly COVID-19 patients: a post-COVID era analysis DOI Creative Commons
Yunhui Li,

Yuan Chen,

Jing Liang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 29, 2024

Advanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. In the post-pandemic era, with containment measures lifted, elderly remain particularly susceptible, highlighting need intensified focus on immune health management.

Language: Английский

Citations

0