Journal of Intensive Medicine,
Journal Year:
2024,
Volume and Issue:
5(2), P. 119 - 126
Published: Nov. 8, 2024
Acute
hypoxemic
respiratory
failure
(AHRF)
is
the
leading
cause
of
intensive
care
unit
(ICU)
admissions.
Of
patients
with
AHRF,
40
%-50
%
will
require
invasive
mechanical
ventilation
during
their
stay
in
ICU,
and
30
%-80
meet
Berlin
Criteria
for
Respiratory
Distress
Syndrome
(ARDS).
Rapid
identification
underlying
AHRF
necessary
before
initiating
targeted
treatment.
Almost
10
ARDS
have
no
identified
classic
risk
factors
however,
precise
may
not
be
up
to
15
patients,
particularly
cases
immunosuppression.
In
these
a
multidisciplinary,
comprehensive,
hierarchical
diagnostic
work-up
mandatory,
including
detailed
history
physical
examination,
chest
computed
tomography,
extensive
microbiological
investigations,
bronchoalveolar
lavage
fluid
cytological
analysis,
immunological
tests,
investigation
possible
involvement
pneumotoxic
drugs.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(8), P. 991 - 991
Published: July 26, 2024
The
knowledge
surrounding
the
application
of
immune
checkpoint
inhibitors
(ICIs)
in
treatment
pediatric
cancers
is
continuously
expanding
and
evolving.
These
therapies
work
by
enhancing
body's
natural
response
against
tumors,
which
may
have
been
suppressed
certain
pathways.
effectiveness
ICIs
treating
adult
has
widely
acknowledged.
However,
results
early
phase
I/II
clinical
trials
that
exclusively
targeted
use
for
different
underwhelming.
rates
to
generally
modest,
except
cases
classic
Hodgkin
lymphoma.
There
seems
be
a
notable
disparity
immunogenicity
childhood
compared
cancers,
potentially
accounting
this
phenomenon.
On
average,
tend
significantly
fewer
neoantigens.
In
recent
times,
there
renewed
sense
optimism
regarding
potential
benefits
ICI
specific
groups
children
with
cancer.
initial
research,
individuals
diagnosed
hypermutated
SMARCB1-deficient
shown
remarkable
positive
outcomes
when
treated
therapies.
This
likely
due
underlying
biological
factors
promote
expression
neoantigens
inflammation
within
tumor.
Ongoing
are
diligently
assessing
cancer
patients
these
subsets.
review
aimed
analyze
safety
types
highly
advanced
malignancies.
Journal of Intensive Medicine,
Journal Year:
2024,
Volume and Issue:
5(2), P. 119 - 126
Published: Nov. 8, 2024
Acute
hypoxemic
respiratory
failure
(AHRF)
is
the
leading
cause
of
intensive
care
unit
(ICU)
admissions.
Of
patients
with
AHRF,
40
%-50
%
will
require
invasive
mechanical
ventilation
during
their
stay
in
ICU,
and
30
%-80
meet
Berlin
Criteria
for
Respiratory
Distress
Syndrome
(ARDS).
Rapid
identification
underlying
AHRF
necessary
before
initiating
targeted
treatment.
Almost
10
ARDS
have
no
identified
classic
risk
factors
however,
precise
may
not
be
up
to
15
patients,
particularly
cases
immunosuppression.
In
these
a
multidisciplinary,
comprehensive,
hierarchical
diagnostic
work-up
mandatory,
including
detailed
history
physical
examination,
chest
computed
tomography,
extensive
microbiological
investigations,
bronchoalveolar
lavage
fluid
cytological
analysis,
immunological
tests,
investigation
possible
involvement
pneumotoxic
drugs.
