Advances in Research on Meningeal Lymphatic Vessels in Central Nervous System Diseases DOI
Huimin Shen,

Bingrui Zhu,

Yajun Qian

et al.

Journal of Craniofacial Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Meningeal lymphatic vessels (mLVs), located around the dural sinuses, are considered significant participants in cerebrospinal fluid (CSF) circulation. not only drain fluids and metabolic waste from brain into deep cervical lymph nodes (dCLNs) but also transport immune cells to dCLNs, thus regulating interaction between central peripheral systems. These play a crucial role maintaining normal physiological functions of nervous system (CNS). involved pathophysiological processes various CNS diseases, including neurodegenerative cerebrovascular tumors. In aging damage dysfunction mLVs have been observed, leading abnormal accumulation toxic substances exacerbating neural damage. By transporting antigen-presenting that taken up antigens within modulate activation their migration infiltration lesions. Certain drug interventions or physical therapies can drainage function mLVs, effectively improving prognosis diseases. This review provides detailed introduction anatomic structure, roles, research advances addition, we propose new strategies for targeting treatment

Language: Английский

PIEZO Ion Channels in Cardiovascular Functions and Diseases DOI
Bertrand Coste, Patrick Delmas

Circulation Research, Journal Year: 2024, Volume and Issue: 134(5), P. 572 - 591

Published: Feb. 29, 2024

The cardiovascular system provides blood supply throughout the body and as such is perpetually applying mechanical forces to cells tissues. Thus, this primed with mechanosensory structures that respond adapt changes in stimuli. Since their discovery 2010, PIEZO ion channels have dominated field of mechanobiology. These been proposed long-sought-after mechanosensitive excitatory involved touch proprioception mammals. However, more pieces evidence point importance activities disease development. channel-related cardiac functions include transducing hemodynamic endothelial vascular cells, red cell homeostasis, platelet aggregation, arterial pressure regulation, among others. contribute pathological conditions including hypertrophy pulmonary hypertension congenital syndromes generalized lymphatic dysplasia xerocytosis. In review, we highlight recent advances understanding role diseases. Achievements quickly expanding should open a new road for efficient control PIEZO-related diseases functions.

Language: Английский

Citations

19
Meningeal Lymphatics in Central Nervous System Diseases DOI
Andrea Francesca Salvador, Nora Abduljawad, Jonathan Kipnis

et al.

Annual Review of Neuroscience, Journal Year: 2024, Volume and Issue: 47(1), P. 323 - 344

Published: April 22, 2024

Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous (CNS) fluid exchange, waste clearance, immune cell trafficking, and privilege. Meningeal lymphatics have also been demonstrated to functionally modify outcome neurological disorders their responses treatment, including brain tumors, inflammatory diseases such as multiple sclerosis, CNS injuries, neurodegenerative Alzheimer's Parkinson's diseases. In this review, we discuss evidence contribution diseases, well available experimental methods for manipulating in these conditions. Finally, provide a discussion pressing questions challenges utilizing prime target therapeutic intervention possibly drug delivery disorders.

Language: Английский

Citations

13
Glymphatic system dysfunction and risk of clinical milestones in patients with Parkinson disease DOI Creative Commons
Cheng Zhou,

Xianchen Jiang,

Xiaojun Guan

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(12)

Published: Oct. 19, 2024

Abstract Background and purpose Glymphatic dysfunction may play a significant role in the development of neurodegenerative diseases. We aimed to evaluate association between glymphatic risk malignant event/clinical milestones Parkinson disease (PD). Methods This study included 236 patients from August 2014 December 2020. Diffusion tensor imaging analysis along perivascular space (DTI‐ALPS) index was calculated as an approximate measure function. The primary outcomes were four clinical including recurrent falls, wheelchair dependence, dementia, placement residential or nursing home care. associations DTI‐ALPS with examined using multivariate Cox proportional hazards regression models. Then, logistic repeated variables individually combination two explore ability distinguish who reached within 5‐year period. Results A total 175 PD baseline follow‐up assessments included. lower independently associated increased dementia. Additionally, 103 monitored over 5 years, model combining showed better performance for predicting dependence years than alone. Conclusions dysfunction, measured by index, PD. finding implies that therapy targeting system serve viable strategy slowing down progression

Language: Английский

Citations

7
Yoda1 opens the lymphatic path for craniosynostosis therapy DOI Creative Commons
Aleksanteri Aspelund, Kari Alitalo

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(4)

Published: Feb. 14, 2024

The rediscovery of meningeal lymphatic vessels (MLVs) has sparked research interest in their function numerous neurological pathologies. Craniosynostosis (CS) is caused by a premature fusion cranial sutures during development. In this issue the JCI, Matrongolo and colleagues show that Twist1-haploinsufficient mice develop CS exhibit raised intracranial pressure, diminished cerebrospinal fluid (CSF) outflow, impaired paravascular CSF-brain flow; all features were associated with MLV defects exacerbated pathology mouse models Alzheimer's disease. Activation mechanosensor Piezo1 Yoda1 restored CSF perfusion aged mice, opening an avenue for further development therapeutics.

Language: Английский

Citations

6
Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow DOI Creative Commons
Xin Rui Lim,

Mohammad M. Abd‐Alhaseeb,

M. Ippolito

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 7, 2024

Hyperemia in response to neural activity is essential for brain health. A hyperemic delivers O

Language: Английский

Citations

6
Research progress on PIEZO1 protein structure and activation mechanism by small-molecule agonists DOI Creative Commons
D. Li, Yuanyuan Song, Yuan Zeng

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102058 - 102058

Published: Jan. 1, 2025

Language: Английский

Citations

0
MR Imaging of Neurofluids in the Developing Brain DOI
Nivedita Agarwal, Willemijn M. Klein, Ruth Tuura

et al.

Neuroimaging Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Covert cerebrospinal fluid dynamics dysfunction: evolution from conventional to innovative therapies DOI Creative Commons
Yi Xu, Hua Yin, Lingge Li

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Cerebrospinal fluid (CSF) dynamics disorders are intricately linked to diverse neurological pathologies, though they usually mild and covert. Contemporary insights into glymphatic system function, particularly the CSF transport, drainage, its role in clearing metabolic waste toxic substances both normal pathological states, pivotal of aquaporin-4 (AQP4) CSF-interstitial (ISF) exchange, have established novel theoretical frameworks subclinical dysfunction, promoted development non-surgical therapeutic approaches for them simultaneously. This review comprehensively analyzes advancement interventions disorders, emphasizing transition from methodologies innovative approaches. Current treatment strategies primarily encompass three directions: pharmacological therapy, physical biological regulation therapy. In terms interventions, developments traditional diuretics small-molecule drugs show promising potential. techniques such as lower body negative pressure, transcranial magnetic stimulation, vagus nerve stimulation provided new options clinical practice. Meanwhile, exemplified by recombinant VEGF-C administration, has paradigms. These demonstrated potential improving enhancing elimination. Future research should focus on developing individualized protocols, elucidating mechanisms, assessing longitudinal outcomes. will facilitate more precise exploration optimized multimodal combinations handling so-called convert dysfunction.

Language: Английский

Citations

0
The glymphatic system in Huntington's disease DOI Creative Commons
Wenzhen Duan,

Zhou Yuan,

Hongshuai Liu

et al.

Journal of Huntington s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

The glymphatic system, a macroscopic waste clearance network in the brain, plays vital role maintaining neuronal health and brain homeostasis. Functionally analogous to lymphatic system other organs, term “glymphatic” combines “glial” “lymphatic.” This facilitates exchange of cerebrospinal fluid (CSF) interstitial (ISF) parenchyma, aiding removal soluble proteins metabolites while distributing essential nutrients signaling molecules. Its functionality is closely tied aquaporin 4 (AQP4) water channels, located primarily on astrocytic endfeet, which mediate movement between CSF ISF. Proper function relies cellular distribution AQP4 channels its astroglial endfeet polarization. Emerging evidence links dysfunction several neurodegenerative disorders, including Huntington's disease (HD). Understanding HD pathogenesis could provide novel insights into new therapeutic approaches. review examines connection HD, highlighting future research directions advancement for HD. It explores pharmacological interventions lifestyle modifications aimed at optimizing improve management.

Language: Английский

Citations

0
Type-I nNOS neurons orchestrate cortical neural activity and vasomotion DOI Open Access
Kevin L. Turner,

Dakota F. Brockway,

Md Shakhawat Hossain

et al.

Published: April 9, 2025

It is unknown how the brain orchestrates coordination of global neural and vascular dynamics. We sought to uncover role a sparse but unusual population genetically-distinct interneurons known as type-I nNOS neurons, using novel pharmacological strategic unilaterally ablate these neurons from somatosensory cortex mice. Region-specific ablation produced changes in both activity dynamics, decreased power delta-band local field potential, reduced sustained responses prolonged sensory stimulation, abolished post-stimulus undershoot cerebral blood volume. Coherence between left right gamma-band envelope volume at ultra-low frequencies was decreased, suggesting type-1 integrate long-range signals. Lastly, we observed decreases amplitude resting-state oscillations vasomotion following neurons. This demonstrates that small nNOS-positive are indispensable for regulating dynamics whole implicates disruption diseases ranging neurodegeneration sleep disturbances.

Language: Английский

Citations

0