Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Dec. 3, 2024
The
immune
system
coordinates
the
response
to
cardiac
injury
and
controls
regenerative
fibrotic
scar
outcomes
in
heart
subsequent
chronic
low-grade
inflammation
associated
with
failure.
Adult
mice
humans
lack
ability
fully
recover
while
adult
zebrafish
spontaneously
regenerate
after
injury.
Here
we
profile
inflammatory
cryoinjury
coronary
artery
ligation
mouse
using
single
cell
transcriptomics.
We
interrogate
extracardiac
reaction
cardiomyocyte
necrosis
assess
specific
peripheral
tissue
stress.
Cardiac
macrophages
play
a
critical
role
determining
homeostasis
by
healing
versus
scarring.
identify
distinct
transcriptional
clusters
of
monocytes/macrophages
(mono/Mϕ)
each
species
find
analogous
pairs
mice.
However,
myocardial
is
largely
disparate
between
zebrafish.
dichotomous
damage
murine
mono/Mϕ
and/or
presence
subtypes
may
underlie
impaired
process
mammals
humans.
Our
study
furnishes
direct
cross-species
comparison
responses
profibrotic
models,
providing
useful
resource
fields
biology
cardiovascular
research.
Dynamic
transcriptomic
analyses
reveal
conserved
upon
models
outcomes.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: Aug. 1, 2024
Abstract
Macrophages
are
versatile
immune
cells
with
remarkable
plasticity,
enabling
them
to
adapt
diverse
tissue
microenvironments
and
perform
various
functions.
Traditionally
categorized
into
classically
activated
(M1)
alternatively
(M2)
phenotypes,
recent
advances
have
revealed
a
spectrum
of
macrophage
activation
states
that
extend
beyond
this
dichotomy.
The
complex
interplay
signaling
pathways,
transcriptional
regulators,
epigenetic
modifications
orchestrates
polarization,
allowing
respond
stimuli
dynamically.
Here,
we
provide
comprehensive
overview
the
cascades
governing
focusing
on
roles
Toll‐like
receptors,
signal
transducer
activator
transcription
proteins,
nuclear
microRNAs.
We
also
discuss
emerging
concepts
metabolic
reprogramming
trained
immunity,
contributing
their
functional
adaptability.
Macrophage
plasticity
plays
pivotal
role
in
repair
regeneration,
macrophages
coordinating
inflammation,
angiogenesis,
matrix
remodeling
restore
homeostasis.
By
harnessing
potential
novel
therapeutic
strategies
targeting
polarization
could
be
developed
for
diseases,
including
chronic
wounds,
fibrotic
disorders,
inflammatory
conditions.
Ultimately,
deeper
understanding
molecular
mechanisms
underpinning
will
pave
way
innovative
regenerative
medicine
engineering
approaches.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(21)
Published: April 6, 2024
Abstract
Myocardial
infarction
(MI)
is
a
critical
global
health
challenge,
with
current
treatments
limited
by
the
complex
MI
microenvironment,
particularly
excessive
oxidative
stress
and
intense
inflammatory
responses
that
exacerbate
cardiac
dysfunction
progression.
Herein,
mannan‐based
nanomedicine,
Que@MOF/Man,
developed
to
target
infarcted
heart
deliver
antioxidative
anti‐inflammatory
agent
quercetin
(Que),
thereby
facilitating
beneficial
myocardial
microenvironment
for
repair.
The
presence
of
mannan
on
nanoparticle
surface
enables
selective
internalization
macrophages
rather
than
cardiomyocytes.
Que@MOF/Man
effectively
neutralizes
reactive
oxygen
species
in
reduce
promote
their
differentiation
into
reparative
phenotype,
reconciling
response
enhancing
cardiomyocyte
survival
through
intercellular
communication.
Owing
recruitment
inflamed
myocardium
post‐MI,
vivo,
administration
rats
revealed
specific
distribution
injured
compared
free
Que.
Furthermore,
exhibited
favorable
results
resolving
inflammation
protecting
cardiomyocytes,
preventing
further
remodeling
improving
function
rats.
These
findings
collectively
validate
rational
design
an
inflammation‐targeted
delivery
strategy
mitigate
modulate
heart,
presenting
therapeutic
avenue
treatment.
Phytomedicine,
Journal Year:
2024,
Volume and Issue:
127, P. 155467 - 155467
Published: Feb. 19, 2024
The
death
and
disability
caused
by
myocardial
infarction
is
a
health
problem
that
needs
to
be
addressed
worldwide,
poor
cardiac
repair
fibrosis
after
seriously
affect
patient
recovery.
Postmyocardial
M2
macrophages
of
great
significance
for
ventricular
remodeling.
Quercitrin
(Que)
common
flavonoid
in
fruits
vegetables
has
antioxidant,
anti-inflammatory,
antitumor
other
effects,
but
whether
it
role
the
treatment
unclear.
In
this
study,
we
constructed
mouse
model
administered
Que.
We
found
through
ultrasound
Que
administration
improved
ejection
fraction
reduced
Staining
heart
sections
detection
marker
protein
levels
revealed
slowed
infarction.
Flow
cytometry
showed
proportion
was
increased
expression
macrophage
markers
were
Que-treated
group.
Finally,
identified
metabolomics
reduces
glycolysis,
increases
aerobic
phosphorylation,
alters
arginine
metabolic
pathways,
polarizing
toward
phenotype.
Our
research
lays
foundation
future
application
cardiovascular
diseases.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Pyroptosis
is
a
key
mode
of
programmed
cell
death
during
the
early
stages
following
acute
myocardial
infarction
(AMI),
driving
immune‐inflammatory
responses.
Cardiac
resident
macrophages
(CRMs)
are
primary
mediators
cardiac
immunity,
and
they
serve
dual
role
through
their
shaping
both
injury
post‐AMI
repair.
To
appropriately
regulate
AMI‐associated
inflammation,
HM4oRL
herein
designed,
an
innovative
bifunctional
therapeutic
nanoplatform
capable
inhibiting
cardiomyocyte
pyroptosis
while
reprogramming
inflammatory
signaling.
This
platform
composed
core
4‐Octyl
itaconate
(4‐OI)‐loaded
liposomes,
middle
layer
consisting
metal‐polyphenol
network
(MPN)
film,
optimized
outer
hybrid
immune‐cell
membrane
layer.
The
unique
properties
this
facilitated
targeting
to
injured
myocardium
early‐stage
AMI
in
mice,
whereupon
release
4‐Ol
modified
MPN
synergistically
inhibited
suppressing
monocytes/macrophage
responses
at
infarcted
site.
Mechanistically,
preserved
metabolic
homeostasis
AMPK
signaling
activation,
establishing
favorable
microenvironmental
conditions
for
CRM‐mediated
inflammation.
Ultimately,
treatment
able
resolve
enhance
neovascularization,
suppress
fibrosis,
reducing
infarct
size
enhancing
repair
such
that
it
approach
targeted
AMI.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 16, 2025
The
gut
microbiota
metabolite,
short-chain
fatty
acids
(SCFAs),
can
protect
against
multiple
cardiovascular
diseases,
while
the
molecular
targets
and
underlying
mechanisms
need
to
be
elucidated.
One
of
primary
SCFA
benefits
was
direct
activation
a
group
G-protein-coupled
receptors
(GPCRs),
termed
free
acid
(FFARs),
FFAR2
(GPR43),
FFAR3
(GPR41).
At
present,
distribution
FFAR2/3
in
cardiac
cells
has
not
been
entirely
clarified.
Using
18
public
single-cell
RNA-seq
single-nuclear
data
human
mouse
hearts,
we
illustrate
entire
atlas
different
regions
cell
types
normal
infarcted
hearts.
We
present
whole
body,
hearts
at
resolution.
also
illustrated
normal/ischemic
newborn
adult
mice
by
combining
newly
built
sc/snRNA-seq
datasets.
These
findings
provide
valuable
information
on
possible
effect
SCFAs
via
heart
references
for
future
studies.
Immunological Investigations,
Journal Year:
2024,
Volume and Issue:
53(3), P. 416 - 436
Published: Jan. 11, 2024
Macrophages
are
significant
immune-related
cells
that
essential
for
tissue
growth,
homeostasis
maintenance,
pathogen
resistance,
and
damage
healing.
The
studies
on
the
metabolic
control
of
macrophage
polarization
state
in
recent
years
influence
status
development
incidence
associated
disorders
expounded
upon
this
article.
Firstly,
we
reviewed
origin
classification
macrophages,
with
particular
attention
paid
to
how
tricarboxylic
acid
cycle
three
primary
metabolites
affect
polarization.
hub
controls
is
cycle.
Finally,
macrophages
influences
onset
progression
cancers,
inflammatory
disorders,
other
illnesses.
Cell Proliferation,
Journal Year:
2024,
Volume and Issue:
57(12)
Published: Aug. 1, 2024
Ischemic
heart
disease
(IHD)
is
a
prevalent
cardiovascular
condition
that
remains
the
primary
cause
of
death
due
to
its
adverse
ventricular
remodelling
and
pathological
changes
in
end-stage
failure.
As
complex
pathologic
condition,
it
involves
intricate
regulatory
processes
at
cellular
molecular
levels.
The
immune
system
are
closely
interconnected,
with
cells
playing
crucial
role
maintaining
cardiac
health
influencing
progression.
Consequently,
alterations
microenvironment
influenced
controlled
by
various
cells,
such
as
macrophages,
neutrophils,
dendritic
eosinophils,
T-lymphocytes,
along
cytokines
they
produce.
Furthermore,
studies
have
revealed
Gata6
