Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior DOI Creative Commons
Francisco J. Flores‐Ramirez, Jessica M. Illenberger, Rémi Martin‐Fardon

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100695 - 100695

Published: Nov. 1, 2024

A major challenge for the treatment of alcohol use disorder (AUD) is relapse to use, even after protracted periods self-imposed abstinence. Stress significantly contributes chronic relapsing nature AUD, given its long-lasting ability elicit intense craving and precipitate relapse. As individuals transition dependence, compensatory allostatic mechanisms result in insults hypothalamic-pituitary-adrenal axis function, mediated by corticotropin-releasing factor (CRF), which subsequently hypothesized alter brain reward pathways, influence affect, craving, ultimately perpetuate problematic drinking vulnerability. Orexin (OX; also called hypocretin) plays a well-established role regulating diverse physiological processes, including stress, has been shown interact with CRF. Interestingly, most hypothalamic cells that express

Language: Английский

A stress-activated mid-insula to BNST pathway regulates susceptibility to abstinence-induced negative affect in female mice DOI Open Access
Benjamin Williams, Joy L. Little, Nathaniel S. O’Connell

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Stress is central to many neuropsychiatric conditions, including alcohol use disorder (AUD). influences the initiation and continued of alcohol, progression AUD, relapse. Identifying neurocircuits activated during stress, individual variability in these responses critical for developing new treatment targets particularly mitigate stress-induced Using a longitudinal approach, this study examined relationship between sub-chronic stress exposure negative affect protracted abstinence following chronic ethanol exposure. Sub-chronic restraint heightened affect-like behavior abstinence. Interestingly, was driven by subset "stress-susceptible" female mice. We mid-insula, hub brain's salience network, as driver effect, given its role emotional regulation links craving, consumption, abstinence-induced affect. Mid-insula GCaMP fiber photometry revealed that activity positively correlated with novelty-suppressed feeding test (NSFT) two weeks into A distinct mice exhibited increasing consummatory phase, implicating mid-insula neural basis Chemogenetic inhibition neurons projecting dorsal BNST disrupted emergence susceptibility, highlighting circuit key determinant susceptibility These outcomes were female-specific, addressing gap understanding AUD risk women. Furthermore, higher struggling than males. However, effect blocked chemogenetic insula-BNST pathway stress. By linking pre-alcohol response outcomes, work positions potential biomarker therapeutic target.

Language: Английский

Citations

0
Addiction and stress: Exploring the reward pathways in brain affected by different drugs DOI

Samira Rostami Mehr,

Babak Nakhaei,

Hossein Soleimani

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Epigenetic Insights into Substance Use Disorder and Associated Psychiatric Conditions DOI Creative Commons
A. Ngo,

Christopher M Ahmad,

Niki Gharavi Alkhansari

et al.

Complex Psychiatry, Journal Year: 2025, Volume and Issue: 11(1), P. 12 - 36

Published: March 3, 2025

Background: Substance use disorder (SUD) is closely associated with epigenetic modifications that significantly impact mental health outcomes. Alcohol and drug misuse induce widespread changes in the epigenome transcriptome of central nervous system, disrupting critical processes such as reward signaling emotional regulation. These alterations regulation gene expression often persist even after substance cessation, potentially contributing to onset or worsening psychiatric conditions, including schizophrenia, depression, stress, anxiety. Summary: This review delves into key mechanisms underlying SUD its comorbid disorders, a focus on DNA methylation, histone modifications, noncoding RNA Additionally, it examines influence environmental biological factors evaluates emerging epigenetic-based therapeutic strategies aimed at treating related conditions. Key Messages: Gaining deeper understanding driving disorders crucial for development effective interventions. highlights potential pharmacological mitigate societal personal burdens linked complications.

Language: Английский

Citations

0
Mental health and well-being in business-to-business markets DOI
Bruno Lussier, Nawar N. Chaker, Melissa Clark

et al.

Industrial Marketing Management, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Digital Detection of Craving and Stress for Individuals in Recovery from Substance Use Disorder: A Qualitative Study DOI Creative Commons
Jazmin Hampton,

Reynalde Eugene,

Nirzari Kapadia

et al.

Drug and Alcohol Dependence Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100336 - 100336

Published: April 1, 2025

Language: Английский

Citations

0
Salivary cortisol trajectories among inpatients undergoing substance use disorder treatment: A prospective repeated-measures study DOI Creative Commons

Eli Otterholt,

Petter Laake,

Stål Bjørkly

et al.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 107477 - 107477

Published: April 1, 2025

Language: Английский

Citations

0
Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior DOI Creative Commons
Francisco J. Flores‐Ramirez, Jessica M. Illenberger, Rémi Martin‐Fardon

et al.

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100695 - 100695

Published: Nov. 1, 2024

A major challenge for the treatment of alcohol use disorder (AUD) is relapse to use, even after protracted periods self-imposed abstinence. Stress significantly contributes chronic relapsing nature AUD, given its long-lasting ability elicit intense craving and precipitate relapse. As individuals transition dependence, compensatory allostatic mechanisms result in insults hypothalamic-pituitary-adrenal axis function, mediated by corticotropin-releasing factor (CRF), which subsequently hypothesized alter brain reward pathways, influence affect, craving, ultimately perpetuate problematic drinking vulnerability. Orexin (OX; also called hypocretin) plays a well-established role regulating diverse physiological processes, including stress, has been shown interact with CRF. Interestingly, most hypothalamic cells that express

Language: Английский

Citations

0